Literature DB >> 30996804

Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity.

Federica Rogati1, Estrella Millán2,3,4, Giovanni Appendino1, Alejandro Correa2,3,4, Diego Caprioglio1, Alberto Minassi1, Eduardo Muñoz2,3,4.   

Abstract

The sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.

Entities:  

Year:  2019        PMID： 30996804      PMCID： PMC6467025          DOI： 10.1021/acsmedchemlett.8b00604

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  10 in total

1.  An NMR spectroscopic method to identify and classify thiol-trapping agents: revival of Michael acceptors for drug discovery?

Authors:  Cristina Avonto; Orazio Taglialatela-Scafati; Federica Pollastro; Alberto Minassi; Vincenzo Di Marzo; Luciano De Petrocellis; Giovanni Appendino
Journal:  Angew Chem Int Ed Engl       Date:  2011-01-10       Impact factor: 15.336

2.  Strigolactones: a novel class of phytohormones that inhibit the growth and survival of breast cancer cells and breast cancer stem-like enriched mammosphere cells.

Authors:  C B Pollock; H Koltai; Y Kapulnik; C Prandi; R I Yarden
Journal:  Breast Cancer Res Treat       Date:  2012-03-29       Impact factor: 4.872

Review 3.  Dimethyl fumarate treatment in multiple sclerosis: Recent advances in clinical and immunological studies.

Authors:  Gwendoline Montes Diaz; Raymond Hupperts; Judith Fraussen; Veerle Somers
Journal:  Autoimmun Rev       Date:  2018-10-12       Impact factor: 9.754

4.  Strigolactones and parasitic weed management 50 years after the discovery of the first natural strigolactone strigol: status and outlook.

Authors:  Claudio Screpanti; Koichi Yoneyama; Harro J Bouwmeester
Journal:  Pest Manag Sci       Date:  2016-11       Impact factor: 4.845

Review 5.  Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach.

Authors:  Antonio Cuadrado; Gina Manda; Ahmed Hassan; María José Alcaraz; Coral Barbas; Andreas Daiber; Pietro Ghezzi; Rafael León; Manuela G López; Baldo Oliva; Marta Pajares; Ana I Rojo; Natalia Robledinos-Antón; Angela M Valverde; Emre Guney; Harald H H W Schmidt
Journal:  Pharmacol Rev       Date:  2018-04       Impact factor: 25.468

6.  Identification of a Novel Hybridization from Isosorbide 5-Mononitrate and Bardoxolone Methyl with Dual Activities of Pulmonary Vasodilation and Vascular Remodeling Inhibition on Pulmonary Arterial Hypertension Rats.

Authors:  Yusheng Cheng; Yan Gong; Shuai Qian; Yi Mou; Hanrui Li; Xijing Chen; Hui Kong; Weiping Xie; Hong Wang; Yihua Zhang; Zhangjian Huang
Journal:  J Med Chem       Date:  2018-02-02       Impact factor: 7.446

Review 7.  Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials.

Authors:  Laurent Meijer; Eric Raymond
Journal:  Acc Chem Res       Date:  2003-06       Impact factor: 22.384

8.  An histidine covalent receptor and butenolide complex mediates strigolactone perception.

Authors:  Alexandre de Saint Germain; Guillaume Clavé; Marie-Ange Badet-Denisot; Jean-Paul Pillot; David Cornu; Jean-Pierre Le Caer; Marco Burger; Frank Pelissier; Pascal Retailleau; Colin Turnbull; Sandrine Bonhomme; Joanne Chory; Catherine Rameau; François-Didier Boyer
Journal:  Nat Chem Biol       Date:  2016-08-01       Impact factor: 15.040

Review 9.  Abscisic Acid: A Novel Nutraceutical for Glycemic Control.

Authors:  Elena Zocchi; Raquel Hontecillas; Andrew Leber; Alexandra Einerhand; Adria Carbo; Santina Bruzzone; Nuria Tubau-Juni; Noah Philipson; Victoria Zoccoli-Rodriguez; Laura Sturla; Josep Bassaganya-Riera
Journal:  Front Nutr       Date:  2017-06-13

Review 10.  Targeting Crosstalk between Nrf-2, NF-κB and Androgen Receptor Signaling in Prostate Cancer.

Authors:  Namrata Khurana; Suresh C Sikka
Journal:  Cancers (Basel)       Date:  2018-09-25       Impact factor: 6.639
  10 in total
  1 in total

Review 1.  Modulation of Nrf2 and NF-κB Signaling Pathways by Naturally Occurring Compounds in Relation to Cancer Prevention and Therapy. Are Combinations Better Than Single Compounds?

Authors:  Violetta Krajka-Kuźniak; Wanda Baer-Dubowska
Journal:  Int J Mol Sci       Date:  2021-07-30       Impact factor: 6.208
  1 in total

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