Literature DB >> 3099639

Genetic analysis and penicillin-binding protein alterations in Neisseria gonorrhoeae with chromosomally mediated resistance.

T J Dougherty.   

Abstract

Eight recent isolates of Neisseria gonorrhoeae with high-level non-beta-lactamase-mediated penicillin resistance were investigated. The penicillin-binding proteins of these strains were found to have reduced affinity for radiolabeled penicillin. Testing for known resistance genes showed that these were present in the resistant isolates. Genetic transformation was used to construct strains with increasing levels of antibiotic resistance. Modification of the transformation protocol made it possible to isolate transformants at the highest (penicillin-resistant DNA donor) level of resistance. These transformants unexpectedly yielded two distinct penicillin-binding protein patterns when tested.

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Year:  1986        PMID： 3099639      PMCID： PMC176507          DOI： 10.1128/AAC.30.5.649

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Specificity of DNA uptake in genetic transformation of gonococci.

Authors:  T J Dougherty; A Asmus; A Tomasz
Journal:  Biochem Biophys Res Commun       Date:  1979-01-15       Impact factor: 3.575

2.  Chromosomally mediated resistance in Neisseria gonorrhoeae in the United States: results of surveillance and reporting, 1983-1984.

Authors:  R J Rice; J W Biddle; Y A JeanLouis; W E DeWitt; J H Blount; S A Morse
Journal:  J Infect Dis       Date:  1986-02       Impact factor: 5.226

3.  Inheritance of low-level resistance to penicillin, tetracycline, and chloramphenicol in Neisseria gonorrhoeae.

Authors:  P F Sparling; F A Sarubbi; E Blackman
Journal:  J Bacteriol       Date:  1975-11       Impact factor: 3.490

4.  Loss of low-level antibiotic resistance in Neisseria gonorrhoeae due to env mutations.

Authors:  F A Sarubbi; P F Sparling; E Blackman; E Lewis
Journal:  J Bacteriol       Date:  1975-11       Impact factor: 3.490

5.  Genetic analysis of drug resistance in Neisseria gonorrhoeae: identification and linkage relationships of loci controlling drug resistance.

Authors:  T W Maier; L Zubrzycki; M B Coyle
Journal:  Antimicrob Agents Chemother       Date:  1975-05       Impact factor: 5.191

6.  Competition of beta-lactam antibiotics for the penicillin-binding proteins of Neisseria gonorrhoeae.

Authors:  T J Dougherty; A E Koller; A Tomasz
Journal:  Antimicrob Agents Chemother       Date:  1981-07       Impact factor: 5.191

7.  Properties of penicillin-binding proteins in Neisseria gonorrhoeae.

Authors:  A G Barbour
Journal:  Antimicrob Agents Chemother       Date:  1981-02       Impact factor: 5.191

8.  Genetic analysis of drug resistance in Neisseria gonorrhoeae: production of increased resistance by the combination of two antibiotic resistance loci.

Authors:  T W Maier; L Zubrzycki; M B Coyle; M Chila; P Warner
Journal:  J Bacteriol       Date:  1975-11       Impact factor: 3.490

9.  Genetic mapping of linked antibiotic resistance loci in Neisseria gonorrhoeae.

Authors:  F A Sarubbi; E Blackman; P F Sparling
Journal:  J Bacteriol       Date:  1974-12       Impact factor: 3.490

10.  Penicillin-binding proteins of penicillin-susceptible and intrinsically resistant Neisseria gonorrhoeae.

Authors:  T J Dougherty; A E Koller; A Tomasz
Journal:  Antimicrob Agents Chemother       Date:  1980-11       Impact factor: 5.191
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  16 in total

Review 1.  Beta-lactamase plasmids and chromosomally mediated antibiotic resistance in pathogenic Neisseria species.

Authors:  J A Dillon; K H Yeung
Journal:  Clin Microbiol Rev       Date:  1989-04       Impact factor: 26.132

2.  The penC mutation conferring antibiotic resistance in Neisseria gonorrhoeae arises from a mutation in the PilQ secretin that interferes with multimer stability.

Authors:  Shuqing Zhao; Deborah M Tobiason; Mei Hu; H Steven Seifert; Robert A Nicholas
Journal:  Mol Microbiol       Date:  2005-09       Impact factor: 3.501

3.  Towards an understanding of chromosomally mediated penicillin resistance in Neisseria gonorrhoeae: evidence for a porin-efflux pump collaboration.

Authors:  William M Shafer; Jason P Folster
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

4.  Porin-mediated antibiotic resistance in Neisseria gonorrhoeae: ion, solute, and antibiotic permeation through PIB proteins with penB mutations.

Authors:  Melanie Olesky; Shuqing Zhao; Robert L Rosenberg; Robert A Nicholas
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

5.  Susceptibility to cephalosporins of penicillin-susceptible and penicillin-resistant strains of Neisseria gonorrhoeae from Philadelphia.

Authors:  T Fekete; D A Serfass; S C Lafredo; K R Cundy
Journal:  Antimicrob Agents Chemother       Date:  1989-02       Impact factor: 5.191

Review 6.  Genetic loci and linkage associations in Neisseria gonorrhoeae and Neisseria meningitidis.

Authors:  S E West; V L Clark
Journal:  Clin Microbiol Rev       Date:  1989-04       Impact factor: 26.132

7.  Mutation in a locus linked to penB-nmp causes suppression of the Mtr phenotype of Neisseria gonorrhoeae.

Authors:  E N Shinners; B W Catlin
Journal:  Antimicrob Agents Chemother       Date:  1988-07       Impact factor: 5.191

Review 8.  Antibiotic resistance in Neisseria gonorrhoeae: origin, evolution, and lessons learned for the future.

Authors:  Magnus Unemo; William M Shafer
Journal:  Ann N Y Acad Sci       Date:  2011-08       Impact factor: 5.691

9.  Standardization of disk diffusion and agar dilution susceptibility tests for Neisseria gonorrhoeae: interpretive criteria and quality control guidelines for ceftriaxone, penicillin, spectinomycin, and tetracycline.

Authors:  R N Jones; T L Gavan; C Thornsberry; P C Fuchs; E H Gerlach; J S Knapp; P Murray; J A Washington
Journal:  J Clin Microbiol       Date:  1989-12       Impact factor: 5.948

10.  Various penA mutations together with mtrR, porB and ponA mutations in Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime or ceftriaxone.

Authors:  Sang-Guk Lee; Hyukmin Lee; Seok Hoon Jeong; Dongeun Yong; Gyung Tae Chung; Yeong Seon Lee; Yunsop Chong; Kyungwon Lee
Journal:  J Antimicrob Chemother       Date:  2010-01-21       Impact factor: 5.790
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