Literature DB >> 807159

Genetic analysis of drug resistance in Neisseria gonorrhoeae: identification and linkage relationships of loci controlling drug resistance.

T W Maier, L Zubrzycki, M B Coyle.   

Abstract

The genetic basis of multiple drug resistance of Neisseria gonorrhoeae was investigated by the technique of transformation. Six different genetic loci were characterized by the type and amount of antibiotic resistance they controlled, and also by the degree of linkage to other resistance markers. A streptomycin resistance locus is linked to separate loci determining resistance to tetracycline, chloramphenicol, and erythromycin. A multiple resistance locus was identified. This genetic locus determines resistance to a variety of antibacterial agents. Lastly, a locus determining resistance to the penicillins was found which is unlinked to any other resistance locus.

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Year:  1975        PMID： 807159      PMCID： PMC429202          DOI： 10.1128/AAC.7.5.676

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  STUDIES ON TRANSFORMATION IN MORAXELLA AND ORGANISMS ASSUMED TO BE RELATED TO MORAXELLA. 1. A METHOD FOR QUANTITATIVE TRANSFORMATION IN MORAXELLA AND NEISSERIA, WITH STREPLOMYCIN RESISTANCE AS THE GENETIC MARKER.

Authors:  K BOEVRE
Journal:  Acta Pathol Microbiol Scand       Date:  1964

2.  Penicillin resistance in Escherichia coli K12: synergism between penicillinases and a barrier in the outer part of the envelope.

Authors:  H G Boman; K Nordström; S Normark
Journal:  Ann N Y Acad Sci       Date:  1974-05-10       Impact factor: 5.691

3.  Multiple antibiotic resistance due to a single mutation in Neisseria gonorrhoeae.

Authors:  M J Maness; P F Sparling
Journal:  J Infect Dis       Date:  1973-09       Impact factor: 5.226

Review 4.  Antibiotic resistance in Neisseria gonorrhoeae.

Authors:  P F Sparling
Journal:  Med Clin North Am       Date:  1972-09       Impact factor: 5.456

5.  Chromosomal location of antibiotic resistance markers in Bacillus subtilis.

Authors:  N Harford; N Sueoka
Journal:  J Mol Biol       Date:  1970-07-28       Impact factor: 5.469

Review 6.  A survey of problems in the antibiotic treatment of gonorrhoea. With special reference to South-East Asia.

Authors:  R R Willcox
Journal:  Br J Vener Dis       Date:  1970-06

7.  Physical evidence of a plasmid in Neisseria gonorrhoeae.

Authors:  P G Engelkirk; D E Schoenhard
Journal:  J Infect Dis       Date:  1973-02       Impact factor: 5.226

8.  Multiple antibiotic resistance in Neisseria gonorrhoeae.

Authors:  T W Maier; H R Beilstein; L Zubrzycki
Journal:  Antimicrob Agents Chemother       Date:  1974-07       Impact factor: 5.191

9.  Studies on transformations of Hemophilus influenzae. II. The molecular weight of transforming DNA by sedimentation and diffusion measurements.

Authors:  S H GOODGAL; R M HERRIOTT
Journal:  J Gen Physiol       Date:  1961-07       Impact factor: 4.086

10.  Studies on transformations of Hemophilus influenzae. IV. Linked and unlinked transformations.

Authors:  S H GOODGAL
Journal:  J Gen Physiol       Date:  1961-11       Impact factor: 4.086
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  19 in total

1.  In-vitro activity of antimicrobial agents against Neisseria gonorrhoeae in Brussels.

Authors:  R Vanhoof; M P Vanderlinden; J M Hubrechts; J P Butzler; E Yourassowsky
Journal:  Br J Vener Dis       Date:  1978-10

Review 2.  The changing pattern of antibiotic resistance of Neisseria gonorrhoeae.

Authors:  C S Easmon
Journal:  Genitourin Med       Date:  1990-04

Review 3.  Beta-lactamase plasmids and chromosomally mediated antibiotic resistance in pathogenic Neisseria species.

Authors:  J A Dillon; K H Yeung
Journal:  Clin Microbiol Rev       Date:  1989-04       Impact factor: 26.132

4.  Genetic analysis and penicillin-binding protein alterations in Neisseria gonorrhoeae with chromosomally mediated resistance.

Authors:  T J Dougherty
Journal:  Antimicrob Agents Chemother       Date:  1986-11       Impact factor: 5.191

Review 5.  Genetic loci and linkage associations in Neisseria gonorrhoeae and Neisseria meningitidis.

Authors:  S E West; V L Clark
Journal:  Clin Microbiol Rev       Date:  1989-04       Impact factor: 26.132

6.  Vancomycin hypersusceptibility in Neisseria gonorrhoeae isolated from patients involves diverse mutations.

Authors:  J A Koelbl; B W Catlin
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191

7.  Identification of drug resistance loci in various clinical isolates of Neisseria gonorrhoeae.

Authors:  T W Maier; P Warner; L Zubryzycki; M Chila
Journal:  Antimicrob Agents Chemother       Date:  1977-09       Impact factor: 5.191

8.  Multiple antibiotic resistance in clinical strains of Neisseria gonorrhoeae isolated in South Carolina.

Authors:  J T Powell; J H Bond
Journal:  Antimicrob Agents Chemother       Date:  1976-10       Impact factor: 5.191

9.  Genetic analysis of drug resistance in Neisseria gonorrhoeae: production of increased resistance by the combination of two antibiotic resistance loci.

Authors:  T W Maier; L Zubrzycki; M B Coyle; M Chila; P Warner
Journal:  J Bacteriol       Date:  1975-11       Impact factor: 3.490

10.  A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection.

Authors:  Ann E Jerse; Nirmala D Sharma; Amy N Simms; Emily T Crow; Lori A Snyder; William M Shafer
Journal:  Infect Immun       Date:  2003-10       Impact factor: 3.441
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