Literature DB >> 30964994

Exact Solutions for Distributions of First-Passage, Direct-Transit, and Looping Times in Symmetric Cusp Potential Barriers and Wells.

Alexander M Berezhkovskii1,2, Leonardo Dagdug3, Sergey M Bezrukov1.   

Abstract

For a particle diffusing in one dimension, the distribution of its first-passage time from point a to point b is determined by the durations of the particle trajectories that start from point a and are terminated as soon as they touch point b for the first time. Any such trajectory consists of looping and direct-transit segments. The latter is the final part of the trajectory that leaves point a and goes to point b without returning to point a. The rest of the trajectory is the looping segment that makes numerous loops which begin and end at the same point a without touching point b. In this article we discuss general relations between the first-passage time distribution and those for the durations of the two segments. These general relations allow us to find exact solutions for the Laplace transforms of the distributions of the first-passage, direct-transit, and looping times for transitions between two points separated by a symmetric cusp potential barrier or well of arbitrary height and depth, respectively. The obtained Laplace transforms are inverted numerically, leading to nontrivial dependences of the resulting distributions on the barrier height and the well depth.

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Year:  2019        PMID: 30964994      PMCID: PMC6749835          DOI: 10.1021/acs.jpcb.9b01616

Source DB:  PubMed          Journal:  J Phys Chem B        ISSN: 1520-5207            Impact factor:   2.991


  31 in total

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Journal:  J Chem Phys       Date:  2004-01-08       Impact factor: 3.488

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3.  Identity of distributions of direct uphill and downhill translocation times for particles traversing membrane channels.

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Journal:  Phys Rev Lett       Date:  2006-07-11       Impact factor: 9.161

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Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2006-04-21

5.  Transition-event durations in one-dimensional activated processes.

Authors:  Bin W Zhang; David Jasnow; Daniel M Zuckerman
Journal:  J Chem Phys       Date:  2007-02-21       Impact factor: 3.488

6.  Single-molecule fluorescence experiments determine protein folding transition path times.

Authors:  Hoi Sung Chung; Kevin McHale; John M Louis; William A Eaton
Journal:  Science       Date:  2012-02-24       Impact factor: 47.728

7.  Transition path times for nucleic Acid folding determined from energy-landscape analysis of single-molecule trajectories.

Authors:  Krishna Neupane; Dustin B Ritchie; Hao Yu; Daniel A N Foster; Feng Wang; Michael T Woodside
Journal:  Phys Rev Lett       Date:  2012-08-06       Impact factor: 9.161

8.  Energy landscape analysis of native folding of the prion protein yields the diffusion constant, transition path time, and rates.

Authors:  Hao Yu; Amar Nath Gupta; Xia Liu; Krishna Neupane; Angela M Brigley; Iveta Sosova; Michael T Woodside
Journal:  Proc Natl Acad Sci U S A       Date:  2012-08-20       Impact factor: 11.205

9.  Fast single-molecule FRET spectroscopy: theory and experiment.

Authors:  Hoi Sung Chung; Irina V Gopich
Journal:  Phys Chem Chem Phys       Date:  2014-09-21       Impact factor: 3.676

10.  Single-molecule fluorescence probes dynamics of barrier crossing.

Authors:  Hoi Sung Chung; William A Eaton
Journal:  Nature       Date:  2013-10-23       Impact factor: 49.962

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  3 in total

1.  Broad distributions of transition-path times are fingerprints of multidimensionality of the underlying free energy landscapes.

Authors:  Rohit Satija; Alexander M Berezhkovskii; Dmitrii E Makarov
Journal:  Proc Natl Acad Sci U S A       Date:  2020-10-21       Impact factor: 11.205

2.  Peculiarities of the Mean Transition Path Time Dependence on the Barrier Height in Entropy Potentials.

Authors:  Alexander M Berezhkovskii; Leonardo Dagdug; Sergey M Bezrukov
Journal:  J Phys Chem B       Date:  2020-03-16       Impact factor: 2.991

3.  The Effect of Time Resolution on Apparent Transition Path Times Observed in Single-Molecule Studies of Biomolecules.

Authors:  Dmitrii E Makarov; Alexander Berezhkovskii; Gilad Haran; Eli Pollak
Journal:  J Phys Chem B       Date:  2022-10-04       Impact factor: 3.466

  3 in total

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