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Literature DB >> 30940398

Regulation of Gene Expression by N⁶-methyladenosine in Cancer.

Abstract

As the most abundant mRNA modification in eukaryotic cells, N6-methyladenosine (m6A) has recently emerged as an important regulator of gene expression. m6A modification can be deposited by m6A methyltransferases, removed by m6A demethylases, and recognized by different reader proteins. Numerous lines of evidence have shown that m6A methylation plays critical roles regulating gene expression in development and disease. In this review, we summarize the molecular and cellular function of m6A and highlight some key results which demonstrate the role of m6A in various cancers. Finally, we discuss future directions for research into m6A and its effects in cancer and the potential for targeting RNA modification in cancer treatment.

Entities: CellLine Chemical Disease Gene Species

Keywords: N(6)-methyladenosine; RNA modification; cancer; gene regulation

Mesh：

Substances：

Year: 2019 PMID： 30940398 PMCID： PMC6527461 DOI： 10.1016/j.tcb.2019.02.008

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

114 in total

1. The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminus.

Authors: R P Perry; D E Kelley; K Friderici; F Rottman
Journal: Cell Date: 1975-04 Impact factor: 41.582

2. Grand challenge commentary: RNA epigenetics?

Authors: Chuan He
Journal: Nat Chem Biol Date: 2010-12 Impact factor: 15.040

3. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.

Authors: Kate D Meyer; Yogesh Saletore; Paul Zumbo; Olivier Elemento; Christopher E Mason; Samie R Jaffrey
Journal: Cell Date: 2012-05-17 Impact factor: 41.582

4. Analysis of global DNA methylation by hydrophilic interaction ultra high-pressure liquid chromatography tandem mass spectrometry.

Authors: Jun-jie Zhang; Lijian Zhang; Keyuan Zhou; Xiaoxia Ye; Chunan Liu; Liangtao Zhang; Jingxuan Kang; Chun Cai
Journal: Anal Biochem Date: 2011-03-09 Impact factor: 3.365

5. Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNA.

Authors: J M Adams; S Cory
Journal: Nature Date: 1975-05-01 Impact factor: 49.962

6. The methylation state of poly A-containing messenger RNA from cultured hamster cells.

Authors: D T Dubin; R H Taylor
Journal: Nucleic Acids Res Date: 1975-10 Impact factor: 16.971

7. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.

Authors: Guanqun Zheng; John Arne Dahl; Yamei Niu; Peter Fedorcsak; Chun-Min Huang; Charles J Li; Cathrine B Vågbø; Yue Shi; Wen-Ling Wang; Shu-Hui Song; Zhike Lu; Ralph P G Bosmans; Qing Dai; Ya-Juan Hao; Xin Yang; Wen-Ming Zhao; Wei-Min Tong; Xiu-Jie Wang; Florian Bogdan; Kari Furu; Ye Fu; Guifang Jia; Xu Zhao; Jun Liu; Hans E Krokan; Arne Klungland; Yun-Gui Yang; Chuan He
Journal: Mol Cell Date: 2012-11-21 Impact factor: 17.970

8. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.

Authors: Guifang Jia; Ye Fu; Xu Zhao; Qing Dai; Guanqun Zheng; Ying Yang; Chengqi Yi; Tomas Lindahl; Tao Pan; Yun-Gui Yang; Chuan He
Journal: Nat Chem Biol Date: 2011-10-16 Impact factor: 15.040

9. Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA.

Authors: Nian Liu; Marc Parisien; Qing Dai; Guanqun Zheng; Chuan He; Tao Pan
Journal: RNA Date: 2013-10-18 Impact factor: 4.942

10. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.

Authors: Dan Dominissini; Sharon Moshitch-Moshkovitz; Schraga Schwartz; Mali Salmon-Divon; Lior Ungar; Sivan Osenberg; Karen Cesarkas; Jasmine Jacob-Hirsch; Ninette Amariglio; Martin Kupiec; Rotem Sorek; Gideon Rechavi
Journal: Nature Date: 2012-04-29 Impact factor: 49.962

60 in total

Review 1. Emerging role of m⁶ A RNA methylation in nutritional physiology and metabolism.

Authors: Jiamin Wu; Katya Frazier; Jingfei Zhang; Zhending Gan; Tian Wang; Xiang Zhong
Journal: Obes Rev Date: 2019-09-02 Impact factor: 9.213

2. RNA modifications and cancer.

Authors: Phensinee Haruehanroengra; Ya Ying Zheng; Yubin Zhou; Yun Huang; Jia Sheng
Journal: RNA Biol Date: 2020-02-07 Impact factor: 4.652

3. N⁷-methylguanosine tRNA modification promotes tumorigenesis and chemoresistance through WNT/β-catenin pathway in nasopharyngeal carcinoma.

Authors: Binbin Chen; Wei Jiang; Ying Huang; Jian Zhang; Peng Yu; Lirong Wu; Hao Peng
Journal: Oncogene Date: 2022-02-26 Impact factor: 9.867

4. FTO promotes multiple myeloma progression by posttranscriptional activation of HSF1 in an m⁶A-YTHDF2-dependent manner.

Authors: Aoshuang Xu; Jiasi Zhang; Liping Zuo; Han Yan; Lei Chen; Fei Zhao; Fengjuan Fan; Jian Xu; Bo Zhang; Yuyang Zhang; Xuejiao Yin; Qianwen Cheng; Su Gao; Jun Deng; Heng Mei; Zhiping Huang; Chunyan Sun; Yu Hu
Journal: Mol Ther Date: 2021-12-13 Impact factor: 11.454

Review 5. How do cells cope with RNA damage and its consequences?

Authors: Liewei L Yan; Hani S Zaher
Journal: J Biol Chem Date: 2019-08-22 Impact factor: 5.157

6. m6A methylation promotes white-to-beige fat transition by facilitating Hif1a translation.

Authors: Ruifan Wu; Yushi Chen; Youhua Liu; Lenan Zhuang; Wei Chen; Botao Zeng; Xing Liao; Guanqun Guo; Yizhen Wang; Xinxia Wang
Journal: EMBO Rep Date: 2021-09-27 Impact factor: 8.807

7. End-labeling-based electrochemical strategy for detection of adenine methylation in nucleic acid by differential pulse voltammetry.

Authors: Hongmei Yang; Yafen Wang; Jing Tang; Fang Wang; Zilin Chen
Journal: Mikrochim Acta Date: 2021-07-12 Impact factor: 5.833

Regulation of Gene Expression by N⁶-methyladenosine in Cancer.

1. The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminus.

2. Grand challenge commentary: RNA epigenetics?

3. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.

4. Analysis of global DNA methylation by hydrophilic interaction ultra high-pressure liquid chromatography tandem mass spectrometry.

5. Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNA.

6. The methylation state of poly A-containing messenger RNA from cultured hamster cells.

7. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.

8. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.

9. Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA.

10. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.

Review 1. Emerging role of m⁶ A RNA methylation in nutritional physiology and metabolism.

2. RNA modifications and cancer.

3. N⁷-methylguanosine tRNA modification promotes tumorigenesis and chemoresistance through WNT/β-catenin pathway in nasopharyngeal carcinoma.

4. FTO promotes multiple myeloma progression by posttranscriptional activation of HSF1 in an m⁶A-YTHDF2-dependent manner.

Review 5. How do cells cope with RNA damage and its consequences?

6. m6A methylation promotes white-to-beige fat transition by facilitating Hif1a translation.

7. End-labeling-based electrochemical strategy for detection of adenine methylation in nucleic acid by differential pulse voltammetry.

Review 8. RNA Modification by m⁶A Methylation in Cardiovascular Disease.

Review 9. Regulatory Role of N6-methyladenosine (m⁶A) Modification in Osteosarcoma.

10. An N6-Methyladenosine-Related Gene Set Variation Score as a Prognostic Tool for Lung Adenocarcinoma.

Review 1. Emerging role of m6 A RNA methylation in nutritional physiology and metabolism.

Review 5. How do cells cope with RNA damage and its consequences?

Review 8. RNA Modification by m6A Methylation in Cardiovascular Disease.

Review 9. Regulatory Role of N6-methyladenosine (m6A) Modification in Osteosarcoma.

Review 1. Emerging role of m⁶ A RNA methylation in nutritional physiology and metabolism.

Review 8. RNA Modification by m⁶A Methylation in Cardiovascular Disease.

Review 9. Regulatory Role of N6-methyladenosine (m⁶A) Modification in Osteosarcoma.