Wenxing Guo1, Long Tan1, Wen Chen1, Lili Fan1, Yanting Chen1, Cong Du1, Mei Zhu2, Hongyan Wei2, Wei Wang1, Min Gao1, Tingkai Cui1, Jun Shen3, Wanqi Zhang4,5,6,7. 1. Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. 2. Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China. 3. Department of Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China. 4. Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. wqzhang@tmu.edu.cn. 5. Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China. wqzhang@tmu.edu.cn. 6. Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China. wqzhang@tmu.edu.cn. 7. Tianjin Center for International Collaborative Research in Environment, Nutrition and Public Health, Tianjin, China. wqzhang@tmu.edu.cn.
Abstract
PURPOSE: The effects of metabolic syndrome (MetS) on thyroid nodules (TN) and thyroid volume (TV), especially the related gender and age disparities, are controversial. In this study, we aimed to assess the relationships between MetS and TN and TV in an adult population. METHODS: This cross-sectional study was performed in an adult population in Tianjin. A total of 2606 subjects were enrolled. TV and TN were measured by thyroid ultrasonography. Blood samples were collected to measure biochemical and metabolic parameters. RESULTS: The prevalence of TN was significantly higher in the MetS (+) group than in the MetS (-) group (P < 0.0001). MetS was independently associated with increased TN risk (OR: 1.24, 95% CI: 1.01-1.51). When stratified by gender, MetS was associated with higher prevalence of TN in males (OR: 1.38, 95% CI: 1.05-1.81) compared with females (OR: 1.02, 95% CI: 0.75-1.39). However, the interaction effect of gender and MetS on TN was not statistically significant (P for interaction = 0.94). MetS was associated with the greater risks of TN in both the <60-year-old group (OR: 1.32, 95% CI: 1.05-1.68) and the ≥60-year-old group (OR: 1.84, 95% CI: 1.24-2.73), while the OR value was significantly higher in the elderly group (P for interaction = 0.03). Additionally, TV was significantly higher in subjects with TN (β = 1.94, P < 0.0001) and MetS (β = 0.94, P = 0.0037). CONCLUSIONS: This study suggested positive relationships between MetS and an increased risk of TN and enlarged TV. Elderly people (≥60 years old) with MetS were associated with a higher risk of TN than younger people (<60 years old). The effect of MetS on TN was not significantly affected by gender.
PURPOSE: The effects of metabolic syndrome (MetS) on thyroid nodules (TN) and thyroid volume (TV), especially the related gender and age disparities, are controversial. In this study, we aimed to assess the relationships between MetS and TN and TV in an adult population. METHODS: This cross-sectional study was performed in an adult population in Tianjin. A total of 2606 subjects were enrolled. TV and TN were measured by thyroid ultrasonography. Blood samples were collected to measure biochemical and metabolic parameters. RESULTS: The prevalence of TN was significantly higher in the MetS (+) group than in the MetS (-) group (P < 0.0001). MetS was independently associated with increased TN risk (OR: 1.24, 95% CI: 1.01-1.51). When stratified by gender, MetS was associated with higher prevalence of TN in males (OR: 1.38, 95% CI: 1.05-1.81) compared with females (OR: 1.02, 95% CI: 0.75-1.39). However, the interaction effect of gender and MetS on TN was not statistically significant (P for interaction = 0.94). MetS was associated with the greater risks of TN in both the <60-year-old group (OR: 1.32, 95% CI: 1.05-1.68) and the ≥60-year-old group (OR: 1.84, 95% CI: 1.24-2.73), while the OR value was significantly higher in the elderly group (P for interaction = 0.03). Additionally, TV was significantly higher in subjects with TN (β = 1.94, P < 0.0001) and MetS (β = 0.94, P = 0.0037). CONCLUSIONS: This study suggested positive relationships between MetS and an increased risk of TN and enlarged TV. Elderly people (≥60 years old) with MetS were associated with a higher risk of TN than younger people (<60 years old). The effect of MetS on TN was not significantly affected by gender.
Authors: Xiaoying Lai; Ping Ouyang; Hong Zhu; Shengli An; Lijuan Xia; Yiting Yao; Han Zhang; Zhi Li; Kan Deng Journal: Nan Fang Yi Ke Da Xue Xue Bao Date: 2020-02-29