Literature DB >> 20515649

Substoichiometric inhibition of Abeta(1-40) aggregation by a tandem Abeta(40-1-Gly8-1-40) peptide.

Sourajit M Mustafi1, Kanchan Garai, Scott L Crick, Berevan Baban, Carl Frieden.   

Abstract

Abeta peptides aggregate to form insoluble and neurotoxic fibrils associated with Alzheimer's disease. Inhibition of the aggregation has been the subject of numerous studies. Here we describe a novel, substoichiometric inhibitor of Abeta(1-40) fibrillization as a tandem dimeric construct consisting of Abeta(40-1) (reverse sequence) linked to Abeta(1-40) via an eight residue glycine linker. At molar ratios of the tandem peptide to Abeta(1-40) of 1:10 to 1:25 inhibition of fibrillization, as measured by ThioflavinT, was observed. We postulate that the tandem construct binds to a fibrillar intermediate but the reverse sequence delays or prevents further monomer association. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20515649      PMCID： PMC2897963          DOI： 10.1016/j.bbrc.2010.05.144

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  21 in total

1.  Development of a proteolytically stable retro-inverso peptide inhibitor of beta-amyloid oligomerization as a potential novel treatment for Alzheimer's disease.

Authors:  Mark Taylor; Susan Moore; Jennifer Mayes; Edward Parkin; Marten Beeg; Mara Canovi; Marco Gobbi; David M A Mann; David Allsop
Journal:  Biochemistry       Date:  2010-04-20       Impact factor: 3.162

2.  A strategy for designing inhibitors of beta-amyloid toxicity.

Authors:  J Ghanta; C L Shen; L L Kiessling; R M Murphy
Journal:  J Biol Chem       Date:  1996-11-22       Impact factor: 5.157

3.  Arrest of beta-amyloid fibril formation by a pentapeptide ligand.

Authors:  L O Tjernberg; J Näslund; F Lindqvist; J Johansson; A R Karlström; J Thyberg; L Terenius; C Nordstedt
Journal:  J Biol Chem       Date:  1996-04-12       Impact factor: 5.157

4.  Selective inhibition of Abeta fibril formation.

Authors:  S J Wood; L MacKenzie; B Maleeff; M R Hurle; R Wetzel
Journal:  J Biol Chem       Date:  1996-02-23       Impact factor: 5.157

5.  Rifampicin prevents the aggregation and neurotoxicity of amyloid beta protein in vitro.

Authors:  T Tomiyama; S Asano; Y Suwa; T Morita; K Kataoka; H Mori; N Endo
Journal:  Biochem Biophys Res Commun       Date:  1994-10-14       Impact factor: 3.575

Review 6.  Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization.

Authors:  M A Findeis
Journal:  Biochim Biophys Acta       Date:  2000-07-26

7.  Inhibition of Alzheimer beta-fibrillogenesis by melatonin.

Authors:  M Pappolla; P Bozner; C Soto; H Shao; N K Robakis; M Zagorski; B Frangione; J Ghiso
Journal:  J Biol Chem       Date:  1998-03-27       Impact factor: 5.157

8.  Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

Authors:  A Lorenzo; B A Yankner
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-06       Impact factor: 11.205

9.  Similarities between beta amyloid peptides 1-40 and 40-1: effects on aggregation, toxicity in vitro, and injection in young and aged rats.

Authors:  T Giordano; J B Pan; L M Monteggia; T F Holzman; S W Snyder; G Krafft; H Ghanbari; N W Kowall
Journal:  Exp Neurol       Date:  1994-02       Impact factor: 5.330

10.  Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.

Authors:  C Soto; E M Sigurdsson; L Morelli; R A Kumar; E M Castaño; B Frangione
Journal:  Nat Med       Date:  1998-07       Impact factor: 53.440
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  3 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2012-11-15       Impact factor: 11.205

2.  The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97.

Authors:  Franziska Trusch; Anja Matena; Maja Vuk; Lisa Koerver; Helene Knævelsrud; Paul S Freemont; Hemmo Meyer; Peter Bayer
Journal:  J Biol Chem       Date:  2015-10-16       Impact factor: 5.157

3.  Probing transient non-native states in amyloid beta fiber elongation by NMR.

Authors:  Jeffrey R Brender; Anirban Ghosh; Samuel A Kotler; Janarthanan Krishnamoorthy; Swapna Bera; Vanessa Morris; Timir Baran Sil; Kanchan Garai; Bernd Reif; Anirban Bhunia; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2019-04-11       Impact factor: 6.222
  3 in total

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