Literature DB >> 3089556

Human calcitonin gene-related peptide possesses weak inhibitory potency of bone resorption in vitro.

I Yamamoto, N Kitamura, J Aoki, C Shigeno, M Hino, K Asonuma, K Torizuka, N Fujii, A Otaka, H Yajima.   

Abstract

Synthetic human calcitonin gene-related peptide (CGRP) was examined for the action on the bone in vitro. Human CGRP inhibited bone resorption stimulated by both human parathyroid hormone and basal. The mode of inhibitory action of human CGRP seemed to be similar to that of calcitonin and the relative potency of human CGRP to inhibit bone resorption is one five-hundredth of that of human calcitonin. Thus, a novel pharmacological action of CGRP was demonstrated.

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Year:  1986        PMID： 3089556     DOI： 10.1007/bf02555747

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  9 in total

1.  [Structure-activity relationship of human calcitonin. III. Biological activity of synthetic analogues with shortened or terminally modified peptide chains (author's transl)].

Authors:  W Rittel; R Maier; M Brugger; B Kamber; B Riniker; P Sieber
Journal:  Experientia       Date:  1976-02-15

Review 2.  Endocrine regulation of calcium metabolism.

Authors:  D H Copp
Journal:  Annu Rev Physiol       Date:  1970       Impact factor: 19.318

3.  Molecular events in developmental regulation of neuroendocrine genes: characterization of the novel neuropeptide CGRP.

Authors:  R M Evans; S Amara; M G Rosenfeld
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1983

4.  Interaction of calcitonin and calcitonin gene-related peptide at receptor sites in target tissues.

Authors:  D Goltzman; J Mitchell
Journal:  Science       Date:  1985-03-15       Impact factor: 47.728

5.  Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products.

Authors:  S G Amara; V Jonas; M G Rosenfeld; E S Ong; R M Evans
Journal:  Nature       Date:  1982-07-15       Impact factor: 49.962

6.  Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide.

Authors:  L A Fisher; D O Kikkawa; J E Rivier; S G Amara; R M Evans; M G Rosenfeld; W W Vale; M R Brown
Journal:  Nature       Date:  1983 Oct 6-12       Impact factor: 49.962

7.  Isolation and characterization of human calcitonin gene-related peptide.

Authors:  H R Morris; M Panico; T Etienne; J Tippins; S I Girgis; I MacIntyre
Journal:  Nature       Date:  1984 Apr 19-25       Impact factor: 49.962

8.  Identification of 1,24(R)-dihydroxyvitamin D3-like bone-resorbing lipid in a patient with cancer-associated hypercalcemia.

Authors:  C Shigeno; I Yamamoto; S Dokoh; M Hino; J Aoki; K Yamada; R Morita; M Kameyama; K Torizuka
Journal:  J Clin Endocrinol Metab       Date:  1985-10       Impact factor: 5.958

9.  Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing.

Authors:  M G Rosenfeld; J J Mermod; S G Amara; L W Swanson; P E Sawchenko; J Rivier; W W Vale; R M Evans
Journal:  Nature       Date:  1983 Jul 14-20       Impact factor: 49.962
  9 in total
  7 in total

1.  Distribution of CGRP-, VIP-, D beta H-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat.

Authors:  E L Hill; R Elde
Journal:  Cell Tissue Res       Date:  1991-06       Impact factor: 5.249

2.  Expression of calcitonin gene-related peptide in rat pulp and periodontal tissues by indirect immunofluorescence method.

Authors:  Yingming Sun; Rui Tao; Mengjie Zhang; Xue Cao; Hong Wang; Lufeng Xue; Meng Wu
Journal:  Monoclon Antib Immunodiagn Immunother       Date:  2013-12

3.  Altered bone development in a mouse model of peripheral sensory nerve inactivation.

Authors:  M A Heffner; M J Anderson; G C Yeh; D C Genetos; B A Christiansen
Journal:  J Musculoskelet Neuronal Interact       Date:  2014-03       Impact factor: 2.041

4.  Alpha-calcitonin gene-related peptide can reverse the catabolic influence of UHMWPE particles on RANKL expression in primary human osteoblasts.

Authors:  Max D Kauther; Jie Xu; Christian Wedemeyer
Journal:  Int J Biol Sci       Date:  2010-09-15       Impact factor: 6.580

5.  Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-κB ligand expression in MG-63 osteoblast-like cells exposed to polyethylene particles.

Authors:  Jie Xu; Max D Kauther; Julia Hartl; Christian Wedemeyer
Journal:  J Orthop Surg Res       Date:  2010-11-04       Impact factor: 2.359

6.  Inhibitory effect of salmon calcitonin on bone resorption: morphological study of the tibial growth plate in rats.

Authors:  U E Pazzaglia; G Zatti; A Di Nucci; A Coci
Journal:  Calcif Tissue Int       Date:  1993-02       Impact factor: 4.333

7.  Bone adaptation to mechanical loading in a mouse model of reduced peripheral sensory nerve function.

Authors:  Mollie A Heffner; Damian C Genetos; Blaine A Christiansen
Journal:  PLoS One       Date:  2017-10-31       Impact factor: 3.240
  7 in total

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