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Literature DB >> 30894734

Protein-slaying drugs could be the next blockbuster therapies.

Megan Scudellari.

Abstract

Keywords: Drug discovery; Molecular biology; Therapeutics

Mesh：

Substances：
Phthalimides

Year: 2019 PMID： 30894734 DOI： 10.1038/d41586-019-00879-3

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

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16 in total

Review 1. Proteolysis-targeting chimeras in drug development: A safety perspective.

Authors: Kevin Moreau; Muireann Coen; Andrew X Zhang; Fiona Pachl; M Paola Castaldi; Goran Dahl; Helen Boyd; Clay Scott; Pete Newham
Journal: Br J Pharmacol Date: 2020-02-25 Impact factor: 8.739

2. Generation of a live attenuated influenza A vaccine by proteolysis targeting.

Authors: Longlong Si; Quan Shen; Jing Li; Li Chen; Jinying Shen; Xue Xiao; Haiqing Bai; Tang Feng; Adam Yongxin Ye; Le Li; Chunhe Zhang; Zhen Li; Ping Wang; Crystal Yuri Oh; Atiq Nurani; Siwen Niu; Chengxin Zhang; Xiaoqiong Wei; Wanqiong Yuan; Hao Liao; Xiaojie Huang; Ning Wang; Wen-Xia Tian; Hongwei Tian; Li Li; Xiaoheng Liu; Roberto Plebani
Journal: Nat Biotechnol Date: 2022-07-04 Impact factor: 68.164

Review 3. The emerging role of mass spectrometry-based proteomics in drug discovery.

Authors: Felix Meissner; Jennifer Geddes-McAlister; Matthias Mann; Marcus Bantscheff
Journal: Nat Rev Drug Discov Date: 2022-03-29 Impact factor: 112.288

Review 4. Ubiquitin ligases: guardians of mammalian development.

Authors: David A Cruz Walma; Zhuoyao Chen; Alex N Bullock; Kenneth M Yamada
Journal: Nat Rev Mol Cell Biol Date: 2022-01-25 Impact factor: 113.915

Review 5. Critical Assessment of Targeted Protein Degradation as a Research Tool and Pharmacological Modality.

Authors: Milka Kostic; Lyn H Jones
Journal: Trends Pharmacol Sci Date: 2020-03-26 Impact factor: 14.819

6. Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.

Authors: Kurt Reichermeier; Daniel C Scott; Lorena Samentar; Jasmin Coulombe-Huntington; Spencer Hill; Luisa Izzi; Xiaojing Tang; Rebeca Ibarra; Thierry Bertomeu; Annie Moradian; Michael J Sweredoski; Nora Caberoy; Brenda A Schulman; Frank Sicheri; Mike Tyers; Gary Kleiger
Journal: Elife Date: 2019-12-23 Impact factor: 8.140

Protein-slaying drugs could be the next blockbuster therapies.

Review 1. Proteolysis-targeting chimeras in drug development: A safety perspective.

2. Generation of a live attenuated influenza A vaccine by proteolysis targeting.

Review 3. The emerging role of mass spectrometry-based proteomics in drug discovery.

Review 4. Ubiquitin ligases: guardians of mammalian development.

Review 5. Critical Assessment of Targeted Protein Degradation as a Research Tool and Pharmacological Modality.

6. Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.

7. Is PROTAC technology really a game changer for central nervous system drug discovery?

8. Systematic characterization of mutations altering protein degradation in human cancers.

9. How Much Can We Bet on Activity of BET Inhibitors Beyond NUT-Midline Carcinoma?

Review 10. Target-Directed Approaches for Screening Small Molecules against RNA Targets.