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Literature DB >> 30891125

Harnessing Polypharmacology with Medicinal Chemistry.

Abstract

Polypharmacology has expanded enormously over the last ten years, with several multitarget drugs (MTDs) already in the market. This Viewpoint provides a basis for a discussion about the critical need to develop MTDs in a more rationale and conscious way. A checklist to maximize success in polypharmacology is proposed.

Year: 2019 PMID： 30891125 PMCID： PMC6421528 DOI： 10.1021/acsmedchemlett.9b00039

Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345

11 in total

Review 1. Can we rationally design promiscuous drugs?

Authors: Andrew L Hopkins; Jonathan S Mason; John P Overington
Journal: Curr Opin Struct Biol Date: 2006-01-25 Impact factor: 6.809

Review 2. Multi-target-directed ligands to combat neurodegenerative diseases.

Authors: Andrea Cavalli; Maria Laura Bolognesi; Anna Minarini; Michela Rosini; Vincenzo Tumiatti; Maurizio Recanatini; Carlo Melchiorre
Journal: J Med Chem Date: 2008-01-09 Impact factor: 7.446

Review 3. Network pharmacology: the next paradigm in drug discovery.

Authors: Andrew L Hopkins
Journal: Nat Chem Biol Date: 2008-11 Impact factor: 15.040

Review 4. Selectively nonselective kinase inhibition: striking the right balance.

Authors: Richard Morphy
Journal: J Med Chem Date: 2010-02-25 Impact factor: 7.446

5. Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds.

Authors: Ewgenij Proschak; Holger Stark; Daniel Merk
Journal: J Med Chem Date: 2018-08-03 Impact factor: 7.446

Review 6. Polypharmacology in a single drug: multitarget drugs.

Authors: M L Bolognesi
Journal: Curr Med Chem Date: 2013 Impact factor: 4.530

Review 7. Polypharmacology: challenges and opportunities in drug discovery.

Authors: Andrew Anighoro; Jürgen Bajorath; Giulio Rastelli
Journal: J Med Chem Date: 2014-06-25 Impact factor: 7.446

8. The physicochemical challenges of designing multiple ligands.

Authors: Richard Morphy; Zoran Rankovic
Journal: J Med Chem Date: 2006-08-10 Impact factor: 7.446

9. A perspective on multi-target drug discovery and design for complex diseases.

Authors: Rona R Ramsay; Marija R Popovic-Nikolic; Katarina Nikolic; Elisa Uliassi; Maria Laura Bolognesi
Journal: Clin Transl Med Date: 2018-01-17

Review 10. Entering the 'big data' era in medicinal chemistry: molecular promiscuity analysis revisited.

Authors: Ye Hu; Jürgen Bajorath
Journal: Future Sci OA Date: 2017-03-06

22 in total

1. Data structures for computational compound promiscuity analysis and exemplary applications to inhibitors of the human kinome.

Authors: Filip Miljković; Jürgen Bajorath
Journal: J Comput Aided Mol Des Date: 2019-12-02 Impact factor: 3.686

2. The phytochemical diversity of commercial Cannabis in the United States.

Authors: Christiana J Smith; Daniela Vergara; Brian Keegan; Nick Jikomes
Journal: PLoS One Date: 2022-05-19 Impact factor: 3.752

Review 3. Expanding the repertoire of methanocarba nucleosides from purinergic signaling to diverse targets.

Authors: Kenneth A Jacobson; Veronica Salmaso; R Rama Suresh; Dilip K Tosh
Journal: RSC Med Chem Date: 2021-07-13

4. Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors.

Authors: Ashish Thakur; Gregory J Tawa; Mark J Henderson; Carina Danchik; Suiyang Liu; Pranav Shah; Amy Q Wang; Garrett Dunn; Md Kabir; Elias C Padilha; Xin Xu; Anton Simeonov; Surender Kharbanda; Richard Stone; Gurmit Grewal
Journal: J Med Chem Date: 2020-04-08 Impact factor: 7.446

5. Introducing the metacore concept for multi-target ligand design.

Authors: Dagmar Stumpfe; Alexander Hoch; Jürgen Bajorath
Journal: RSC Med Chem Date: 2021-04-15

6. α-Linolenic Acid-Valproic Acid Conjugates: Toward Single-Molecule Polypharmacology for Multiple Sclerosis.

Authors: Michele Rossi; Sabrina Petralla; Michele Protti; Monica Baiula; Tereza Kobrlova; Ondrej Soukup; Santi Mario Spampinato; Laura Mercolini; Barbara Monti; Maria Laura Bolognesi
Journal: ACS Med Chem Lett Date: 2020-10-27 Impact factor: 4.345

7. Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 inhibitors.

Authors: Regina Martínez; Bruno Di Geronimo; Miryam Pastor; José María Zapico; Claire Coderch; Rostyslav Panchuk; Nadia Skorokhyd; Maciej Maslyk; Ana Ramos; Beatriz de Pascual-Teresa
Journal: Molecules Date: 2020-03-25 Impact factor: 4.411

8. Discovery of talmapimod analogues as polypharmacological anti-inflammatory agents.

Authors: Wandong Liu; Caiyun Hou; Jiaming Li; Xiaodong Ma; Yanchun Zhang; Mengqi Hu; Yuanzheng Huang
Journal: J Enzyme Inhib Med Chem Date: 2020-12 Impact factor: 5.051

9. Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones.

Authors: Mariagrazia Rullo; Marco Catto; Antonio Carrieri; Modesto de Candia; Cosimo Damiano Altomare; Leonardo Pisani
Journal: Molecules Date: 2019-12-09 Impact factor: 4.411

10. Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease.

Authors: Natalia Szałaj; Justyna Godyń; Jakub Jończyk; Anna Pasieka; Dawid Panek; Tomasz Wichur; Krzysztof Więckowski; Paula Zaręba; Marek Bajda; Anja Pislar; Barbara Malawska; Raimon Sabate; Anna Więckowska
Journal: J Enzyme Inhib Med Chem Date: 2020-12 Impact factor: 5.051