Literature DB >> 20166671

Selectively nonselective kinase inhibition: striking the right balance.

Richard Morphy1.   

Abstract

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Year:  2010        PMID： 20166671     DOI： 10.1021/jm901132v

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  60 in total

1.  A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis.

Authors:  J Kankanala; A M Latham; A P Johnson; S Homer-Vanniasinkam; C W G Fishwick; S Ponnambalam
Journal:  Br J Pharmacol       Date:  2012-05       Impact factor: 8.739

Review 2.  The influence of the 'organizational factor' on compound quality in drug discovery.

Authors:  Paul D Leeson; Stephen A St-Gallay
Journal:  Nat Rev Drug Discov       Date:  2011-09-30       Impact factor: 84.694

Review 3.  Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore.

Authors:  Fraser F Fleming; Lihua Yao; P C Ravikumar; Lee Funk; Brian C Shook
Journal:  J Med Chem       Date:  2010-08-30       Impact factor: 7.446

4.  Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures.

Authors:  Yan Li; Dong Joon Kim; Weiya Ma; Ronald A Lubet; Ann M Bode; Zigang Dong
Journal:  J Chem Inf Model       Date:  2011-10-12       Impact factor: 4.956

5.  Discovery of Bivalent Kinase Inhibitors via Enzyme-Templated Fragment Elaboration.

Authors:  Frank E Kwarcinski; Michael E Steffey; Christel C Fox; Matthew B Soellner
Journal:  ACS Med Chem Lett       Date:  2015-07-13       Impact factor: 4.345

6.  Computational Modeling of Kinase Inhibitor Selectivity.

Authors:  Govindan Subramanian; Manish Sud
Journal:  ACS Med Chem Lett       Date:  2010-07-28       Impact factor: 4.345

7.  Development of a highly selective c-Src kinase inhibitor.

Authors:  Kristoffer R Brandvold; Michael E Steffey; Christel C Fox; Matthew B Soellner
Journal:  ACS Chem Biol       Date:  2012-06-04       Impact factor: 5.100

8.  Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.

Authors:  Val S Goodfellow; Colin J Loweth; Satheesh B Ravula; Torsten Wiemann; Thong Nguyen; Yang Xu; Daniel E Todd; David Sheppard; Scott Pollack; Oksana Polesskaya; Daniel F Marker; Stephen Dewhurst; Harris A Gelbard
Journal:  J Med Chem       Date:  2013-10-03       Impact factor: 7.446

9.  Interaction network among functional drug groups.

Authors:  Minho Lee; Keunwan Park; Dongsup Kim
Journal:  BMC Syst Biol       Date:  2013-10-16

10.  Kinome-wide activity modeling from diverse public high-quality data sets.

Authors:  Stephan C Schürer; Steven M Muskal
Journal:  J Chem Inf Model       Date:  2013-01-09       Impact factor: 4.956
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