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Literature DB >> 30887985

New insights into the metal-induced oxidative degradation pathways of transthyretin.

Michael L Poltash¹, Mehdi Shirzadeh, Jacob W McCabe, Zahra Moghadamchargari, Arthur Laganowsky, David H Russell.

Abstract

The amyloidogenic mechanism of transthyretin is still debated but understanding it fully could lend insight into disease progression and potential therapeutics. Transthyretin was investigated revealing a metal-induced (Cr/Cu) oxidation pathway leading to N-terminal backbone fragmentation and oligomer formation; previously hidden details were revealed only by FT-IM-Orbitrap MS and surface-induced dissociation.

Entities: Chemical Disease Gene Mutation Species

Year: 2019 PMID： 30887985 PMCID： PMC6452628 DOI： 10.1039/c9cc00682f

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

20 in total

Review 1. Native protein mass spectrometry: from intact oligomers to functional machineries.

Authors: Robert H H van den Heuvel; Albert J R Heck
Journal: Curr Opin Chem Biol Date: 2004-10 Impact factor: 8.822

2. Oxidation inhibits amyloid fibril formation of transthyretin.

Authors: Simin D Maleknia; Natàlia Reixach; Joel N Buxbaum
Journal: FEBS J Date: 2006-12 Impact factor: 5.542

3. Oxidation artifacts in the electrospray mass spectrometry of Abeta Peptide.

Authors: Maolian Chen; Kelsey D Cook
Journal: Anal Chem Date: 2007-01-24 Impact factor: 6.986

4. Gas-phase unfolding and disassembly reveals stability differences in ligand-bound multiprotein complexes.

Authors: Suk-Joon Hyung; Carol V Robinson; Brandon T Ruotolo
Journal: Chem Biol Date: 2009-04-24

5. Electrochemically induced pH changes resulting in protein unfolding in the ion source of an electrospray mass spectrometer.

Authors: L Konermann; E A Silva; O F Sogbein
Journal: Anal Chem Date: 2001-10-15 Impact factor: 6.986

Review 6. The transthyretin-retinol-binding protein complex.

Authors: H L Monaco
Journal: Biochim Biophys Acta Date: 2000-10-18

7. Expression, purification, and in vitro cysteine-10 modification of native sequence recombinant human transthyretin.

Authors: Jonathan S Kingsbury; Elena S Klimtchuk; Roger Théberge; Catherine E Costello; Lawreen H Connors
Journal: Protein Expr Purif Date: 2007-01-17 Impact factor: 1.650

Review 8. Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses.

Authors: Yoshiki Sekijima; Jeffery W Kelly; Shu-ichi Ikeda
Journal: Curr Pharm Des Date: 2008 Impact factor: 3.116

9. X-ray absorption spectroscopy reveals a substantial increase of sulfur oxidation in transthyretin (TTR) upon fibrillization.

Authors: Luís Gales; Isabel Cardoso; Barbara Fayard; Alexandre Quintanilha; Maria J Saraiva; Ana M Damas
Journal: J Biol Chem Date: 2003-01-21 Impact factor: 5.157

Review 10. Transthyretin as a thyroid hormone carrier: function revisited.

Authors: Joana Almeida Palha
Journal: Clin Chem Lab Med Date: 2002-12 Impact factor: 3.694

11 in total

1. Molecular Mechanism of ISC Iron-Sulfur Cluster Biogenesis Revealed by High-Resolution Native Mass Spectrometry.

Authors: Cheng-Wei Lin; Jacob W McCabe; David H Russell; David P Barondeau
Journal: J Am Chem Soc Date: 2020-03-17 Impact factor: 15.419

2. First-Principles Collision Cross Section Measurements of Large Proteins and Protein Complexes.

Authors: Jacob W McCabe; Christopher S Mallis; Klaudia I Kocurek; Michael L Poltash; Mehdi Shirzadeh; Michael J Hebert; Liqi Fan; Thomas E Walker; Xueyun Zheng; Ting Jiang; Shiyu Dong; Cheng-Wei Lin; Arthur Laganowsky; David H Russell
Journal: Anal Chem Date: 2020-07-28 Impact factor: 6.986

3. Structural Analysis of the Effect of a Dual-FLAG Tag on Transthyretin.

Authors: Mehdi Shirzadeh; Michael L Poltash; Arthur Laganowsky; David H Russell
Journal: Biochemistry Date: 2020-03-02 Impact factor: 3.162

4. Intrinsic GTPase Activity of K-RAS Monitored by Native Mass Spectrometry.

Authors: Zahra Moghadamchargari; Jamison Huddleston; Mehdi Shirzadeh; Xueyun Zheng; David E Clemmer; Frank M Raushel; David H Russell; Arthur Laganowsky
Journal: Biochemistry Date: 2019-07-22 Impact factor: 3.162

Review 5. Variable-Temperature Native Mass Spectrometry for Studies of Protein Folding, Stabilities, Assembly, and Molecular Interactions.

Authors: Arthur Laganowsky; David E Clemmer; David H Russell
Journal: Annu Rev Biophys Date: 2021-12-21 Impact factor: 19.763

6. Discovery of Potent Charge-Reducing Molecules for Native Ion Mobility Mass Spectrometry Studies.

Authors: Jixing Lyu; Yang Liu; Jacob W McCabe; Samantha Schrecke; Lei Fang; David H Russell; Arthur Laganowsky
Journal: Anal Chem Date: 2020-07-31 Impact factor: 6.986

7. Native IM-Orbitrap MS: Resolving What Was Hidden.

Authors: Michael L Poltash; Jacob W McCabe; Mehdi Shirzadeh; Arthur Laganowsky; David H Russell
Journal: Trends Analyt Chem Date: 2019-05-31 Impact factor: 12.296

Review 8. THE IMS PARADOX: A PERSPECTIVE ON STRUCTURAL ION MOBILITY-MASS SPECTROMETRY.

Authors: Jacob W McCabe; Michael J Hebert; Mehdi Shirzadeh; Christopher S Mallis; Joanna K Denton; Thomas E Walker; David H Russell
Journal: Mass Spectrom Rev Date: 2020-07-01 Impact factor: 10.946

9. Variable-Temperature Electrospray Ionization for Temperature-Dependent Folding/Refolding Reactions of Proteins and Ligand Binding.

Authors: Jacob W McCabe; Mehdi Shirzadeh; Thomas E Walker; Cheng-Wei Lin; Benjamin J Jones; Vicki H Wysocki; David P Barondeau; David E Clemmer; Arthur Laganowsky; David H Russell
Journal: Anal Chem Date: 2021-04-27 Impact factor: 6.986

Review 10. Approaches to Heterogeneity in Native Mass Spectrometry.

Authors: Amber D Rolland; James S Prell
Journal: Chem Rev Date: 2021-09-01 Impact factor: 72.087