Background luminescence in x-ray luminescence computed tomography (XLCT) imaging.

X-ray luminescence computed tomography (XLCT) is an emerging hybrid imaging modality. It has been recently reported that materials such as water, tissue, or even air can generate optical photons upon x-ray irradiation, which can increase the noises in measurements of XLCT. In this study, we have investigated the x-ray luminescence from water, air, as well as tissue mimicking phantoms, including one embedded with a 0.01 mg/mL GOS:Eu3+ microphosphor target. We have measured the optical emission spectrum from each sample, including samples of meat and fat, using a spectrograph. Our results indicate that there are plenty of optical photons emitted by x-ray irradiation, and a small nanophosphor concentration, as low as 5.28 μM in a deep background, can provide enough contrast for XLCT imaging.