| Literature DB >> 30869843 |
Carlos F Aylwin1, Carlos A Toro1, Elizabeth Shirtcliff2, Alejandro Lomniczi1.
Abstract
The adolescent transition begins with the onset of puberty which, upstream in the brain, is initiated by the gonadotropin-releasing hormone (GnRH) pulse generator that activates the release of peripheral sex hormones. Substantial research in human and animal models has revealed a myriad of cellular networks and heritable genes that control the GnRH pulse generator allowing the individual to begin the process of reproductive competence and sexual maturation. Here, we review the latest knowledge in neuroendocrine pubertal research with emphasis on genetic and epigenetic mechanisms underlying the pubertal transition.Entities:
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Year: 2019 PMID: 30869843 DOI: 10.1111/jora.12385
Source DB: PubMed Journal: J Res Adolesc ISSN: 1050-8392