Megan M Herting1,2, Kristina A Uban3,4, Marybel Robledo Gonzalez5,6, Fiona C Baker7, Eric C Kan2,6, Wesley K Thompson8, Douglas A Granger4,9,10, Matthew D Albaugh1, Andrey P Anokhin11, Kara S Bagot12, Marie T Banich13, Deanna M Barch14, Arielle Baskin-Sommers15, Florence J Breslin16, B J Casey15, Bader Chaarani17, Linda Chang18, Duncan B Clark19, Christine C Cloak18, R Todd Constable20, Linda B Cottler21, Rada K Dagher22, Mirella Dapretto23, Anthony S Dick24, Nico Dosenbach25, Gayathri J Dowling26, Julie A Dumas17, Sarah Edwards27, Thomas Ernst18, Damien A Fair28, Sarah W Feldstein-Ewing29, Edward G Freedman30, Bernard F Fuemmeler31, Hugh Garavan17, Dylan G Gee15, Jay N Giedd32, Paul E A Glaser11, Aimee Goldstone7, Kevin M Gray33, Samuel W Hawes24, Andrew C Heath11, Mary M Heitzeg34, John K Hewitt13, Charles J Heyser35, Elizabeth A Hoffman26, Rebekah S Huber36, Marilyn A Huestis37, Luke W Hyde38, M Alejandra Infante5, Masha Y Ivanova1, Joanna Jacobus32, Terry L Jernigan39, Nicole R Karcher11, Angela R Laird40, Kimberly H LeBlanc26, Krista Lisdahl41, Monica Luciana42, Beatriz Luna19, Hermine H Maes43, Andrew T Marshall2,44, Michael J Mason45, Erin C McGlade36, Amanda S Morris16,46, Bonnie J Nagel47, Gretchen N Neigh48, Clare E Palmer35, Martin P Paulus16, Alexandra S Potter17, Leon I Puttler34, Nishadi Rajapakse22, Kristina Rapuano15, Gloria Reeves27, Perry F Renshaw49, Claudiu Schirda50, Kenneth J Sher51, Chandni Sheth49, Paul D Shilling5, Lindsay M Squeglia33, Matthew T Sutherland24, Susan F Tapert2, Rachel L Tomko33, Deborah Yurgelun-Todd49, Natasha E Wade5, Susan R B Weiss26, Robert A Zucker34, Elizabeth R Sowell6. 1. Preventive Medicine, University of Southern California, Los Angeles, CA, United States. 2. Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States. 3. Public Health, University of California, Irvine, Irvine, CA, United States. 4. Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, Irvine, CA, United States. 5. Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States. 6. Research on Children, Youth, and Families, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States. 7. Center for Health Sciences, SRI International, Menlo Park, CA, United States. 8. Division of Biostatistics, University of California, San Diego, La Jolla, CA, United States. 9. Social Ecology, University of California, Irvine, Irvine, CA, United States. 10. Bloomberg School of Public Health, Johns Hopkins University, Baltimore, CA, United States. 11. Department of Psychiatry, Washington University, St. Louis, MO, United States. 12. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. 13. Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States. 14. Department of Psychological and Brain Sciences, Washington University, St. Louis, MO, United States. 15. Department of Psychology, University of Yale, New Haven, CT, United States. 16. Laureate Institute for Brain Research, Tulsa, OK, United States. 17. Department of Psychiatry, University of Vermont, Burlington, VT, United States. 18. Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States. 19. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States. 20. Radiology and Biomedical Imaging, University of Yale, New Haven, CT, United States. 21. Department of Epidemiology, University of Florida, Gainesville, FL, United States. 22. Division of Scientific Programs, National Institute on Minority Health and Health Disparities, Bethesda, MD, United States. 23. Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States. 24. Department of Psychology, Florida International University, Miami, FL, United States. 25. Department of Neurology, Washington University, St. Louis, MO, United States. 26. Division of Extramural Research, National Institute on Drug Abuse, Bethesda, MD, United States. 27. Department of Psychiatry, University of Maryland, Baltimore, MD, United States. 28. Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States. 29. Department of Psychology, University of Rhode Island, Kingston, RI, United States. 30. Department of Neuroscience, University of Rochester, Rochester, NY, United States. 31. Health Behavior and Policy, Virginia Commonwealth University, Richmon, VA, United States. 32. Department of Psychiatry, University of San Diego, La Jolla, CA, United States. 33. Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States. 34. Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States. 35. Center for Human Development, University of California, San Diego, La Jolla, CA, United States. 36. Department of Psychiatry, University of Utah, Salt Lake City, UT, United States. 37. Medical Cannabis & Science Program, Thomas Jefferson University, Philadelphia, PA, United States. 38. Department of Psychology, University of Michigan, Ann Arbor, MI, United States. 39. Department of Cognitive Science, University of San Diego, La Jolla, CA, United States. 40. Department of Physics, Florida International University, Miami, FL, United States. 41. Department of Psychology, University of Wisconsin, Milwaukee, WI, United States. 42. Department of Psychology, University of Minnesota, Minneapolis, MN, United States. 43. Human & Molecular Genetics, Virginia Commonwealth University, Richmond, VT, United States. 44. Department of Pediatrics, University of Southern California, Los Angeles, CA, United States. 45. Center for Behavioral Health Research, University of Tennessee, Knoxville, TN, United States. 46. Human Development and Family Science, Oklahoma State University, Tulsa, OK, United States. 47. Department of Psychiatry, Oregon Health & Science University, Portland, OR, United States. 48. Anatomy & Neurobiology, Virginia Commonwealth University, Richmond, VT, United States. 49. Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, United States. 50. Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States. 51. Department of Psychology, University of Missouri, Columbia, MO, United States.
Abstract
Aim: To examine individual variability between perceived physical features and hormones of pubertal maturation in 9-10-year-old children as a function of sociodemographic characteristics. Methods: Cross-sectional metrics of puberty were utilized from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study-a multi-site sample of 9-10 year-olds (n = 11,875)-and included perceived physical features via the pubertal development scale (PDS) and child salivary hormone levels (dehydroepiandrosterone and testosterone in all, and estradiol in females). Multi-level models examined the relationships among sociodemographic measures, physical features, and hormone levels. A group factor analysis (GFA) was implemented to extract latent variables of pubertal maturation that integrated both measures of perceived physical features and hormone levels. Results: PDS summary scores indicated more males (70%) than females (31%) were prepubertal. Perceived physical features and hormone levels were significantly associated with child's weight status and income, such that more mature scores were observed among children that were overweight/obese or from households with low-income. Results from the GFA identified two latent factors that described individual differences in pubertal maturation among both females and males, with factor 1 driven by higher hormone levels, and factor 2 driven by perceived physical maturation. The correspondence between latent factor 1 scores (hormones) and latent factor 2 scores (perceived physical maturation) revealed synchronous and asynchronous relationships between hormones and concomitant physical features in this large young adolescent sample. Conclusions: Sociodemographic measures were associated with both objective hormone and self-report physical measures of pubertal maturation in a large, diverse sample of 9-10 year-olds. The latent variables of pubertal maturation described a complex interplay between perceived physical changes and hormone levels that hallmark sexual maturation, which future studies can examine in relation to trajectories of brain maturation, risk/resilience to substance use, and other mental health outcomes.
Aim: To examine individual variability between perceived physical features and hormones of pubertal maturation in 9-10-year-old children as a function of sociodemographic characteristics. Methods: Cross-sectional metrics of puberty were utilized from the baseline assessment of the Adolescent Brain Cognitive Development (ABCD) Study-a multi-site sample of 9-10 year-olds (n = 11,875)-and included perceived physical features via the pubertal development scale (PDS) and child salivary hormone levels (dehydroepiandrosterone and testosterone in all, and estradiol in females). Multi-level models examined the relationships among sociodemographic measures, physical features, and hormone levels. A group factor analysis (GFA) was implemented to extract latent variables of pubertal maturation that integrated both measures of perceived physical features and hormone levels. Results: PDS summary scores indicated more males (70%) than females (31%) were prepubertal. Perceived physical features and hormone levels were significantly associated with child's weight status and income, such that more mature scores were observed among children that were overweight/obese or from households with low-income. Results from the GFA identified two latent factors that described individual differences in pubertal maturation among both females and males, with factor 1 driven by higher hormone levels, and factor 2 driven by perceived physical maturation. The correspondence between latent factor 1 scores (hormones) and latent factor 2 scores (perceived physical maturation) revealed synchronous and asynchronous relationships between hormones and concomitant physical features in this large young adolescent sample. Conclusions: Sociodemographic measures were associated with both objective hormone and self-report physical measures of pubertal maturation in a large, diverse sample of 9-10 year-olds. The latent variables of pubertal maturation described a complex interplay between perceived physical changes and hormone levels that hallmark sexual maturation, which future studies can examine in relation to trajectories of brain maturation, risk/resilience to substance use, and other mental health outcomes.
Authors: Julianna Deardorff; John P Ekwaru; Lawrence H Kushi; Bruce J Ellis; Louise C Greenspan; Anousheh Mirabedi; Evelyn G Landaverde; Robert A Hiatt Journal: J Adolesc Health Date: 2010-09-20 Impact factor: 5.012
Authors: James N Roemmich; Robert M Blizzard; Shyamal D Peddada; Robert M Malina; Alex F Roche; James M Tanner; Alan D Rogol Journal: Am J Hum Biol Date: 1997 Impact factor: 1.937
Authors: Marcia E Herman-Giddens; Jennifer Steffes; Donna Harris; Eric Slora; Michael Hussey; Steven A Dowshen; Richard Wasserman; Janet R Serwint; Lynn Smitherman; Edward O Reiter Journal: Pediatrics Date: 2012-10-20 Impact factor: 7.124
Authors: Nandita Vijayakumar; George Youssef; Nicholas B Allen; Vicki Anderson; Daryl Efron; Lisa Mundy; George Patton; Julian G Simmons; Tim Silk; Sarah Whittle Journal: Compr Psychoneuroendocrinol Date: 2021-07-27
Authors: Theresa W Cheng; Lucía Magis-Weinberg; Victoria Guazzelli Williamson; Cecile D Ladouceur; Sarah L Whittle; Megan M Herting; Kristina A Uban; Michelle L Byrne; Marjolein E A Barendse; Elizabeth A Shirtcliff; Jennifer H Pfeifer Journal: Front Endocrinol (Lausanne) Date: 2021-05-05 Impact factor: 6.055
Authors: Marjolein E A Barendse; Michelle L Byrne; John C Flournoy; Elizabeth A McNeilly; Victoria Guazzelli Williamson; Ann-Marie Y Barrett; Samantha J Chavez; Elizabeth A Shirtcliff; Nicholas B Allen; Jennifer H Pfeifer Journal: J Psychopathol Clin Sci Date: 2021-12-23
Authors: Clare E Palmer; Chandni Sheth; Andrew T Marshall; Shana Adise; Fiona C Baker; Linda Chang; Duncan B Clark; Clarisa Coronado; Rada K Dagher; Vanessa Diaz; Gayathri J Dowling; Marybel R Gonzalez; Frank Haist; Megan M Herting; Rebekah S Huber; Terry L Jernigan; Kimberly LeBlanc; Karen Lee; Krista M Lisdahl; Gretchen Neigh; Megan W Patterson; Perry Renshaw; Kyung E Rhee; Susan Tapert; Wesley K Thompson; Kristina Uban; Elizabeth R Sowell; Deborah Yurgelun-Todd Journal: Front Pediatr Date: 2021-10-05 Impact factor: 3.418