Seon Hee Lim1, Nayoung Kim2,3, Jin Won Kwon4, Sung Eun Kim5, Gwang Ho Baik6, Ju Yup Lee7, Kyung Sik Park7, Jeong Eun Shin8, Hyun Joo Song9, Dae-Seong Myung10, Suck Chei Choi11, Hyun Jin Kim12, Joo Hyun Lim1, Jeong Yoon Yim1, Joo Sung Kim1,13. 1. Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center Seoul National University Hospital, Seoul, South Korea. 2. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea. nayoungkim49@empas.com. 3. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea. nayoungkim49@empas.com. 4. College of Pharmacy, Kyungpook National University, Daegu, South Korea. 5. Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea. 6. Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Kangwon-do, South Korea. 7. Department of Internal Medicine, Keimyung University College of Medicine, Daegu, South Korea. 8. Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Chungcheongnam-do, South Korea. 9. Department of Internal Medicine, Jeju National University School of Medicine, Jeju, South Korea. 10. Department of Internal Medicine, Chonnam National University School of Medicine, Hwasun, Chollanam-do, South Korea. 11. Department of Internal Medicine, Wonkwang University College of Medicine, Iksan, Chollabuk-do, South Korea. 12. Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Gyeongsangnam-do, South Korea. 13. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
Abstract
BACKGROUND AND AIM: Helicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population. METHODS: Anthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria. RESULTS: After excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2% in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P < 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with H. pylori seropositivity. Finally, the prevalence of metabolic syndrome was higher in H. pylori-seropositive subjects than in negative ones (27.2% vs. 21.0%, P < 0.05), and H. pylori seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95% CI 1.09-1.31, P < 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between H. pylori seropositivity and metabolic syndrome disappeared in those ≥ 65 years old. CONCLUSIONS: H. pylori infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65 years old.
BACKGROUND AND AIM: Helicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population. METHODS: Anthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria. RESULTS: After excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2% in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P < 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with H. pylori seropositivity. Finally, the prevalence of metabolic syndrome was higher in H. pylori-seropositive subjects than in negative ones (27.2% vs. 21.0%, P < 0.05), and H. pylori seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95% CI 1.09-1.31, P < 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between H. pylori seropositivity and metabolic syndrome disappeared in those ≥ 65 years old. CONCLUSIONS:H. pylori infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65 years old.
Authors: Won Seok Kim; Yonghoon Choi; Nayoung Kim; Seon Hee Lim; Gitark Noh; Ki Wook Kim; Jaehyung Park; Hyeongho Jo; Hyuk Yoon; Cheol Min Shin; Young Soo Park; Dong Ho Lee Journal: Korean J Intern Med Date: 2022-01-07 Impact factor: 3.165