Michael A Sugarman1, Ann C McKee2, Thor D Stein3, Yorghos Tripodis4, Lilah M Besser5, Brett Martin6, Joseph N Palmisano6, Eric G Steinberg7, Maureen K O'Connor1, Rhoda Au8, Michael McClean9, Ronald Killiany10, Jesse Mez11, Michael W Weiner12, Neil W Kowall13, Robert A Stern14, Michael L Alosco15. 1. Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Edith Nourse Rogers Memorial Veterans Hospital, Department of Neuropsychology, Bedford, MA, USA. 2. Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA; VA Boston Healthcare System, Boston, MA, USA; Department of Veterans Affairs Medical Center, Bedford, MA, USA. 3. Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA; VA Boston Healthcare System, Boston, MA, USA; Department of Veterans Affairs Medical Center, Bedford, MA, USA. 4. Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. 5. National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA. 6. Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, MA, USA. 7. Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA. 8. Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Framingham Heart Study, National Heart, Lung, and Blood Institute, Boston, MA, USA; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA; Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA, USA. 9. Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA. 10. Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA, USA; Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA; Center for Biomedical Imaging, Boston University School of Medicine, Boston, MA, USA. 11. Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA. 12. Department of Veteran Affairs Medical Center, Center for Imaging and Neurodegenerative Diseases, San Francisco, CA, USA; Departments of Radiology and Biomedical Imaging, Medicine, Psychiatry, and Neurology, University of California, San Francisco, CA, USA. 13. Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA; Neurology Service, VA Boston Healthcare System, Boston, MA, USA. 14. Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA, USA; Department of Neurosurgery, Boston University School of Medicine, Boston, MA, USA. 15. Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA. Electronic address: malosco@bu.edu.
Abstract
INTRODUCTION: Recent research with neuropathologic or biomarker evidence of Alzheimer's disease (AD) casts doubt on traumatic brain injury (TBI) as a risk factor for AD. We leveraged the National Alzheimer's Coordinating Center to examine the association between self-reported TBI with loss of consciousness and AD neuropathologic changes, and with baseline and longitudinal clinical status. METHODS: The sample included 4761 autopsy participants (453 with remote TBI with loss of consciousness; 2822 with AD neuropathologic changes) from National Alzheimer's Coordinating Center. RESULTS: Self-reported TBI did not predict AD neuropathologic changes (P > .10). Reported TBI was not associated with baseline or change in dementia severity or cognitive function in participants with or without autopsy-confirmed AD. DISCUSSION: Self-reported TBI with loss of consciousness may not be an independent risk factor for clinical or pathological AD. Research that evaluates number and severity of TBIs is needed to clarify the neuropathological links between TBI and dementia documented in other large clinical databases.
INTRODUCTION: Recent research with neuropathologic or biomarker evidence of Alzheimer's disease (AD) casts doubt on traumatic brain injury (TBI) as a risk factor for AD. We leveraged the National Alzheimer's Coordinating Center to examine the association between self-reported TBI with loss of consciousness and AD neuropathologic changes, and with baseline and longitudinal clinical status. METHODS: The sample included 4761 autopsy participants (453 with remote TBI with loss of consciousness; 2822 with AD neuropathologic changes) from National Alzheimer's Coordinating Center. RESULTS: Self-reported TBI did not predict AD neuropathologic changes (P > .10). Reported TBI was not associated with baseline or change in dementia severity or cognitive function in participants with or without autopsy-confirmed AD. DISCUSSION: Self-reported TBI with loss of consciousness may not be an independent risk factor for clinical or pathological AD. Research that evaluates number and severity of TBIs is needed to clarify the neuropathological links between TBI and dementia documented in other large clinical databases.
Authors: Raquel C Gardner; Katherine L Possin; Christopher P Hess; Eric J Huang; Lea T Grinberg; Amber L Nolan; Brendan I Cohn-Sheehy; Pia M Ghosh; Serggio Lanata; Jennifer Merrilees; Joel H Kramer; Mitchel S Berger; Bruce L Miller; Kristine Yaffe; Gil D Rabinovici Journal: Neurol Clin Pract Date: 2015-08
Authors: Inga K Koerte; Elizabeth Nichols; Yorghos Tripodis; Vivian Schultz; Stefan Lehner; Randy Igbinoba; Alice Z Chuang; Michael Mayinger; Eliana M Klier; Marc Muehlmann; David Kaufmann; Christian Lepage; Florian Heinen; Gerd Schulte-Körne; Ross Zafonte; Martha E Shenton; Anne B Sereno Journal: J Neurotrauma Date: 2017-06-09 Impact factor: 5.269
Authors: Ann C McKee; Robert A Stern; Christopher J Nowinski; Thor D Stein; Victor E Alvarez; Daniel H Daneshvar; Hyo-Soon Lee; Sydney M Wojtowicz; Garth Hall; Christine M Baugh; David O Riley; Caroline A Kubilus; Kerry A Cormier; Matthew A Jacobs; Brett R Martin; Carmela R Abraham; Tsuneya Ikezu; Robert Ross Reichard; Benjamin L Wolozin; Andrew E Budson; Lee E Goldstein; Neil W Kowall; Robert C Cantu Journal: Brain Date: 2012-12-02 Impact factor: 13.501
Authors: Jeff Schaffert; Christian LoBue; Charles L White; Hsueh-Sheng Chiang; Nyaz Didehbani; Laura Lacritz; Heidi Rossetti; Marisara Dieppa; John Hart; C Munro Cullum Journal: Neuropsychology Date: 2018-02-01 Impact factor: 3.295
Authors: Michael Jarrett; Roger Tam; Enedino Hernández-Torres; Nancy Martin; Warren Perera; Yinshan Zhao; Elham Shahinfard; Shiroy Dadachanji; Jack Taunton; David K B Li; Alexander Rauscher Journal: Front Neurol Date: 2016-02-12 Impact factor: 4.003
Authors: Leslie Grasset; M Maria Glymour; Kristine Yaffe; Samuel L Swift; Kan Z Gianattasio; Melinda C Power; Adina Zeki Al Hazzouri Journal: Alzheimers Dement Date: 2020-04-22 Impact factor: 21.566
Authors: Taylor J Krivanek; Seth A Gale; Brittany M McFeeley; Casey M Nicastri; Kirk R Daffner Journal: J Alzheimers Dis Date: 2021 Impact factor: 4.472
Authors: Kristen Dams-O'Connor; Patrick S F Bellgowan; Roderick Corriveau; Mary Jo Pugh; Douglas H Smith; Julie A Schneider; Keith Whitaker; Henrik Zetterberg Journal: J Neurotrauma Date: 2021-12 Impact factor: 5.269
Authors: Suzan van Amerongen; Dewi K Caton; Yolande A L Pijnenburg; Philip Scheltens; Everard G B Vijverberg Journal: Dement Geriatr Cogn Dis Extra Date: 2022-09-16
Authors: Michelle M Mielke; Neelum T Aggarwal; Clara Vila-Castelar; Puja Agarwal; Eider M Arenaza-Urquijo; Benjamin Brett; Anna Brugulat-Serrat; Lyndsey E DuBose; Willem S Eikelboom; Jason Flatt; Nancy S Foldi; Sanne Franzen; Paola Gilsanz; Wei Li; Alison J McManus; Debora Melo van Lent; Sadaf Arefi Milani; C Elizabeth Shaaban; Shana D Stites; Erin Sundermann; Vidyani Suryadevara; Jean-Francoise Trani; Arlener D Turner; Jet M J Vonk; Yakeel T Quiroz; Ganesh M Babulal Journal: Alzheimers Dement Date: 2022-04-08 Impact factor: 16.655
Authors: Breton M Asken; William G Mantyh; Renaud La Joie; Amelia Strom; Kaitlin B Casaletto; Adam M Staffaroni; Alexandra C Apple; Cutter A Lindbergh; Leonardo Iaccarino; Michelle You; Harli Grant; Corrina Fonseca; Charles Windon; Kyan Younes; Jeremy Tanner; Gil D Rabinovici; Joel H Kramer; Raquel C Gardner Journal: Brain Imaging Behav Date: 2021-01-11 Impact factor: 3.224
Authors: Michael L Alosco; Yorghos Tripodis; Zachary H Baucom; Jesse Mez; Thor D Stein; Brett Martin; Olivia Haller; Shannon Conneely; Michael McClean; Rachel Nosheny; Scott Mackin; Ann C McKee; Michael W Weiner; Robert A Stern Journal: Neurology Date: 2020-06-26 Impact factor: 11.800
Authors: Benjamin L Brett; Raquel C Gardner; Jonathan Godbout; Kristen Dams-O'Connor; C Dirk Keene Journal: Biol Psychiatry Date: 2021-06-02 Impact factor: 13.382