Leslie Grasset1,2, M Maria Glymour3, Kristine Yaffe4, Samuel L Swift5, Kan Z Gianattasio6, Melinda C Power6, Adina Zeki Al Hazzouri7. 1. Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, University of Bordeaux, Inserm, Bordeaux, France. 2. Inserm, CIC1401-EC, Bordeaux, France. 3. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA. 4. Department of Neurology, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA. 5. Division of Epidemiology, Department of Public Health Sciences, University of Miami, Coral Gables, Florida, USA. 6. Department of Epidemiology and Biostatistics, Milken Institute School of Public Heath, George Washington University, Washington, DC, USA. 7. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
Abstract
INTRODUCTION: To examine associations of history of traumatic brain injuries (TBIs) with loss of consciousness (LOC) with dementia incidence and memory decline. METHODS: We studied 2718 participants from the 1992 enrollment cohort of the Health and Retirement Study (HRS) aged 65 years or older in 2000. History of TBI with LOC was self-reported in 1992. Dementia was assessed using four algorithms established in HRS. Participants were followed from 2000 to 2014 with repeated measures of dementia and memory performance. Cox models and linear mixed-effects models were used. RESULTS: In 1992, 11.9% of the participants reported a history of TBI with LOC. In fully adjusted models for all four algorithms, participants with a history of TBI with LOC had no statistically significant difference in dementia incidence nor in memory decline, compared to participants without TBI history. DISCUSSION: Our study did not find evidence of a long-term association between history of TBI with LOC (of unknown frequency and severity) and dementia incidence or memory decline.
INTRODUCTION: To examine associations of history of traumatic brain injuries (TBIs) with loss of consciousness (LOC) with dementia incidence and memory decline. METHODS: We studied 2718 participants from the 1992 enrollment cohort of the Health and Retirement Study (HRS) aged 65 years or older in 2000. History of TBI with LOC was self-reported in 1992. Dementia was assessed using four algorithms established in HRS. Participants were followed from 2000 to 2014 with repeated measures of dementia and memory performance. Cox models and linear mixed-effects models were used. RESULTS: In 1992, 11.9% of the participants reported a history of TBI with LOC. In fully adjusted models for all four algorithms, participants with a history of TBI with LOC had no statistically significant difference in dementia incidence nor in memory decline, compared to participants without TBI history. DISCUSSION: Our study did not find evidence of a long-term association between history of TBI with LOC (of unknown frequency and severity) and dementia incidence or memory decline.
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