Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A role for FNDC5/Irisin in the beneficial effects of exercise on the brain and in neurodegenerative diseases.

Literature DB >> 30844383

A role for FNDC5/Irisin in the beneficial effects of exercise on the brain and in neurodegenerative diseases.

Michael F Young¹, Sophia Valaris¹, Christiane D Wrann².

Abstract

The beneficial effects of exercise on the brain are well known. However, the underlying molecular mechanisms are much less well understood. Interestingly, myokines, hormones secreted by muscle in response to exercise, gained attention as such beneficial mediators. In this review, we will focus on FNDC5 and its secreted form, the newly discovered myokine "irisin". We will discuss their role in the beneficial effects of exercise and its potential application in neurodegenerative disorders.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Cognition; Exercise; FNDC5; Hippocampus; Irisin; Neurodegeneration; Physical activity

Mesh：

Substances：

Year: 2019 PMID： 30844383 PMCID： PMC6955153 DOI： 10.1016/j.pcad.2019.02.007

Source DB: PubMed Journal: Prog Cardiovasc Dis ISSN： 0033-0620 Impact factor: 8.194

71 in total

1. Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway.

Authors: Olivia C Küster; Daria Laptinskaya; Patrick Fissler; Cathrin Schnack; Martina Zügel; Verena Nold; Franka Thurm; Sina Pleiner; Alexander Karabatsiakis; Björn von Einem; Patrick Weydt; André Liesener; Andreas Borta; Alexander Woll; Bastian Hengerer; Iris-Tatjana Kolassa; Christine A F von Arnim
Journal: J Alzheimers Dis Date: 2017 Impact factor: 4.472

2. Metabolic adaptations in skeletal muscle, adipose tissue, and whole-body oxidative capacity in response to resistance training.

Authors: Malin Alvehus; Niklas Boman; Karin Söderlund; Michael B Svensson; Jonas Burén
Journal: Eur J Appl Physiol Date: 2014-04-08 Impact factor: 3.078

3. Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation.

Authors: Joo Young Huh; Vassilis Mougios; Athanasios Kabasakalis; Ioannis Fatouros; Aikaterina Siopi; Ioannis I Douroudos; Andreas Filippaios; Grigorios Panagiotou; Kyung Hee Park; Christos S Mantzoros
Journal: J Clin Endocrinol Metab Date: 2014-08-13 Impact factor: 5.958

4. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus.

Authors: H van Praag; G Kempermann; F H Gage
Journal: Nat Neurosci Date: 1999-03 Impact factor: 24.884

5. Total daily physical activity and the risk of AD and cognitive decline in older adults.

Authors: A S Buchman; P A Boyle; L Yu; R C Shah; R S Wilson; D A Bennett
Journal: Neurology Date: 2012-04-18 Impact factor: 9.910

6. Enhanced expression of FNDC5 in human embryonic stem cell-derived neural cells along with relevant embryonic neural tissues.

Authors: Fatemeh Ahmadi Ghahrizjani; Kamran Ghaedi; Ahmad Salamian; Somayeh Tanhaei; Alireza Shoaraye Nejati; Hossein Salehi; Mohammad Nabiuni; Hossein Baharvand; Mohammad Hossein Nasr-Esfahani
Journal: Gene Date: 2014-12-08 Impact factor: 3.688

7. The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans.

Authors: Frode Norheim; Torgrim Mikal Langleite; Marit Hjorth; Torgeir Holen; Anders Kielland; Hans Kristian Stadheim; Hanne Løvdal Gulseth; Kåre Inge Birkeland; Jørgen Jensen; Christian A Drevon
Journal: FEBS J Date: 2013-12-10 Impact factor: 5.542

8. Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure.

Authors: Stewart H Lecker; Alexandra Zavin; Peirang Cao; Ross Arena; Kelly Allsup; Karla M Daniels; Jacob Joseph; P Christian Schulze; Daniel E Forman
Journal: Circ Heart Fail Date: 2012-09-20 Impact factor: 8.790

9. Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease.

Authors: Bernadeta Michalski; Margaret Fahnestock
Journal: Brain Res Mol Brain Res Date: 2003-03-17

10. Brain-derived neurotrophic factor ameliorates learning deficits in a rat model of Alzheimer's disease induced by aβ1-42.

Authors: Lu Zhang; Yu Fang; Yajun Lian; Yuan Chen; Tianwen Wu; Yake Zheng; Huili Zong; Limin Sun; Ruifang Zhang; Zhenhua Wang; Yuming Xu
Journal: PLoS One Date: 2015-04-07 Impact factor: 3.240

21 in total

1. State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.

Authors: Kaleen M Lavin; Paul M Coen; Liliana C Baptista; Margaret B Bell; Devin Drummer; Sara A Harper; Manoel E Lixandrão; Jeremy S McAdam; Samia M O'Bryan; Sofhia Ramos; Lisa M Roberts; Rick B Vega; Bret H Goodpaster; Marcas M Bamman; Thomas W Buford
Journal: Compr Physiol Date: 2022-03-09 Impact factor: 8.915

2. Irisin induces white adipose tissue browning in mice as assessed by magnetic resonance imaging.

Authors: Yue Chen; Jie Ding; Yufei Zhao; Shenghong Ju; Hui Mao; Xin-Gui Peng
Journal: Exp Biol Med (Maywood) Date: 2021-04-22

3. The effects of an aerobic training intervention on cognition, grey matter volumes and white matter microstructure.

Authors: Claire E Sexton; Jill F Betts; Andrea Dennis; Aiden Doherty; Paul Leeson; Cameron Holloway; Erica Dall'Armellina; Anderson M Winkler; Naiara Demnitz; Thomas Wassenaar; Helen Dawes; Heidi Johansen-Berg
Journal: Physiol Behav Date: 2020-05-29

Review 4. Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration.

Authors: B Mahalakshmi; Nancy Maurya; Shin-Da Lee; V Bharath Kumar
Journal: Int J Mol Sci Date: 2020-08-16 Impact factor: 5.923

Review 5. Physical Activity and Brain Health.

Authors: Carlo Maria Di Liegro; Gabriella Schiera; Patrizia Proia; Italia Di Liegro
Journal: Genes (Basel) Date: 2019-09-17 Impact factor: 4.096

6. Upregulation of FNDC5 gene expression in C2C12 cells after single and combined treatments of resveratrol and ATRA.

Authors: Elahe Abedi-Taleb; Zahra Vahabi; Ehsan Sekhavati-Moghadam; Leila Khedmat; Shima Jazayeri; Ali Akbar Saboor-Yaraghi
Journal: Lipids Health Dis Date: 2019-10-22 Impact factor: 3.876

7. FNDC5/irisin improves the therapeutic efficacy of bone marrow-derived mesenchymal stem cells for myocardial infarction.

Authors: Jingyu Deng; Ning Zhang; Yong Wang; Chao Yang; Yabin Wang; Chao Xin; Jinming Zhao; Zhitao Jin; Feng Cao; Zheng Zhang
Journal: Stem Cell Res Ther Date: 2020-06-10 Impact factor: 6.832