Literature DB >> 3084383

Immunization studies with attenuated strains of Bacillus anthracis.

B E Ivins, J W Ezzell, J Jemski, K W Hedlund, J D Ristroph, S H Leppla.   

Abstract

Live, attenuated strains of Bacillus anthracis lacking either the capsule plasmid pXO2, the toxin plasmid pXO1, or both were tested for their efficacy as vaccines against intravenous challenge with anthrax toxin in Fischer 344 rats and against aerosol or intramuscular challenge with virulent anthrax spores in Hartley guinea pigs. Animals immunized with toxigenic, nonencapsulated (pXO1+, pXO2-) strains survived toxin and spore challenge and demonstrated postimmunization antibody titers to the three components of anthrax toxin (protective antigen, lethal factor, and edema factor). Immunization with two nontoxigenic, encapsulated (pXO1-, pXO2+), Pasteur vaccine strains neither provided protection nor elicited titers to any of the toxin components. Therefore, to immunize successfully against anthrax toxin or spore challenge, attenuated, live strains of B. anthracis must produce the toxin components specified by the pXO1 plasmid.

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Year:  1986        PMID： 3084383      PMCID： PMC261020          DOI： 10.1128/iai.52.2.454-458.1986

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  16 in total

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Authors:  J L STANLEY; H SMITH
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2.  Large-scale production of protective antigen of Bacillus anthracis in anaerobic cultures.

Authors:  M PUZISS; L C MANNING; J W LYNCH; I ABELOW; G G WRIGHT
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Authors:  I A DEARMON; F KLEIN; R E LINCOLN; B G MAHLANDT; A L FERNELIUS
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4.  Modifications to the Henderson apparatus for studying air-borne infections. Evaluations using aerosols of Listeria monocytogenes.

Authors:  W G ROESSLER; D A KAUTTER
Journal:  J Infect Dis       Date:  1962 Jan-Feb       Impact factor: 5.226

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Authors:  P S Brachman; H Gold; S A Plotkin; F R Fekety; M Werrin; N R Ingraham
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6.  Value of field data for extrapolation in anthrax.

Authors:  R E Lincoln; J S Walker; F Klein; A J Rosenwald; W I Jones
Journal:  Fed Proc       Date:  1967-09

7.  Bacillus anthracis calmodulin-dependent adenylate cyclase: chemical and enzymatic properties and interactions with eucaryotic cells.

Authors:  S H Leppla
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Authors:  J D Ristroph; B E Ivins
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10.  QUANTITATIVE ASSAY FOR CRUDE ANTHRAX TOXINS.

Authors:  B W HAINES; F KLEIN; R E LINCOLN
Journal:  J Bacteriol       Date:  1965-01       Impact factor: 3.490
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  67 in total

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6.  Capsule synthesis by Bacillus anthracis is required for dissemination in murine inhalation anthrax.

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Authors:  B E Ivins; S L Welkos; G B Knudson; S F Little
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8.  Detailed genomic analysis of the Wbeta and gamma phages infecting Bacillus anthracis: implications for evolution of environmental fitness and antibiotic resistance.

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9.  Role of anthrax toxins in dissemination, disease progression, and induction of protective adaptive immunity in the mouse aerosol challenge model.

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10.  A spontaneous translational fusion of Bacillus cereus PlcR and PapR activates transcription of PlcR-dependent genes in Bacillus anthracis via binding with a specific palindromic sequence.

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