Literature DB >> 20639373

Accidental selection and intentional restoration of sporulation-deficient Bacillus anthracis mutants.

Inka Sastalla1, M J Rosovitz, Stephen H Leppla.   

Abstract

We demonstrate the frequent accidental enrichment of spontaneous sporulation-deficient mutants of Bacillus anthracis on solid medium and identify contributing factors. Mutations in spo0A, encoding the master regulator of sporulation initiation, were found in 38 of 53 mutants. Transductions using bacteriophage CP51 propagated on sporogenic bacteria allowed for the restoration of sporulation phenotypes.

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Year:  2010        PMID: 20639373      PMCID: PMC2937495          DOI: 10.1128/AEM.00950-10

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN: 0099-2240            Impact factor:   4.792


  26 in total

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Authors:  P Fawcett; P Eichenberger; R Losick; P Youngman
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9.  DNA complexed structure of the key transcription factor initiating development in sporulating bacteria.

Authors:  Haiyan Zhao; Tarek Msadek; James Zapf; James A Hoch; Kottayil I Varughese
Journal:  Structure       Date:  2002-08       Impact factor: 5.006

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  8 in total

Review 1.  Occurrence, recognition, and reversion of spontaneous, sporulation-deficient Bacillus anthracis mutants that arise during laboratory culture.

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Review 2.  Cell Death Pathway That Monitors Spore Morphogenesis.

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4.  The Clostridium difficile spo0A gene is a persistence and transmission factor.

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5.  A Quality-Control Mechanism Removes Unfit Cells from a Population of Sporulating Bacteria.

Authors:  Irene S Tan; Cordelia A Weiss; David L Popham; Kumaran S Ramamurthi
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6.  Bacillus cereus G9241 S-layer assembly contributes to the pathogenesis of anthrax-like disease in mice.

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Journal:  J Bacteriol       Date:  2012-11-30       Impact factor: 3.490

7.  Laboratory strains of Bacillus anthracis lose their ability to rapidly grow and sporulate compared to wildlife outbreak strains.

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8.  Emergence of a non-sporulating secondary phenotype in Clostridium (Clostridioides) difficile ribotype 078 isolated from humans and animals.

Authors:  M C Connor; J W McGrath; G McMullan; N Marks; M Guelbenzu; D J Fairley
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  8 in total

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