Zhiyong Zhao1,2, Guojun Xu1,2, Bin Sun3, Xuzhou Li2,4, Zhe Shen3, Shangda Li3, Yi Xu5, Manli Huang5, Dongrong Xu6. 1. Shanghai Key Laboratory of Magnetic Resonance, Key Laboratory of Brain Functional Genomics (MOE & STCSM), Institute of Cognitive Neuroscience, East China Normal University, Shanghai, 200062, China. 2. Department of Psychiatry & New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, New York, NY, 10032, USA. 3. College of Medicine, Zhejiang University, No. 268, Kaixuan Road, Hangzhou, 310000, China. 4. Key Laboratory of Brain Functional Genomics (MOE & STCSM), Institute of Cognitive Neuroscience, East China Normal University, Shanghai, 200062, China. 5. Department of Psychiatry, The First Affiliated Hospital, The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, 310003, China. 6. Department of Psychiatry & New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, New York, NY, 10032, USA. xu.dongrong@columbia.edu.
Abstract
PURPOSE: A recent study has reported that schizophrenia patients show an uncoupled association between intraventricular brain temperature (BT) and cerebral blood flow (CBF). CBF has been found to be closely coupled with spontaneous brain activities (SBAs) derived from resting-state BOLD fMRI metrics. Yet, it is unclear so far whether the relationship between the intraventricular BT and the SBAs may change in patients with adolescent-onset schizophrenia (AOS) compared with that in healthy controls (HCs). METHODS: The present study recruited 28 first-episode, drug-naïve AOS patients and 22 matched HCs. We measured the temperature of the lateral ventricles (LV) using diffusion-weighted imaging thermometry and measured SBAs using both regional homogeneity and amplitude of low-frequency fluctuation methods. A nonparametric Wilcoxon rank sum test was used to detect the difference in intraventricular BT between AOS patients and HCs with LV volume, age, and sex as covariates. We also evaluated the relationship between the intraventricular BT and the SBAs using partial correlation analysis controlling for LV volume, age, and sex. RESULTS: We found that HCs showed a significant negative correlation between the intraventricular BT and the local SBAs in the bilateral putamina and left superior temporal gyrus, while such a correlation was absent in AOS patients. Additionally, no significant difference between the two groups was found in the intraventricular BT. CONCLUSION: These findings suggest that AOS patients may experience an uncoupling between intraventricular BT and SBAs in several schizophrenia-related brain areas, which may be associated with the altered relationships among intraventricular BT, CBF, and metabolism.
PURPOSE: A recent study has reported that schizophreniapatients show an uncoupled association between intraventricular brain temperature (BT) and cerebral blood flow (CBF). CBF has been found to be closely coupled with spontaneous brain activities (SBAs) derived from resting-state BOLD fMRI metrics. Yet, it is unclear so far whether the relationship between the intraventricular BT and the SBAs may change in patients with adolescent-onset schizophrenia (AOS) compared with that in healthy controls (HCs). METHODS: The present study recruited 28 first-episode, drug-naïve AOSpatients and 22 matched HCs. We measured the temperature of the lateral ventricles (LV) using diffusion-weighted imaging thermometry and measured SBAs using both regional homogeneity and amplitude of low-frequency fluctuation methods. A nonparametric Wilcoxon rank sum test was used to detect the difference in intraventricular BT between AOSpatients and HCs with LV volume, age, and sex as covariates. We also evaluated the relationship between the intraventricular BT and the SBAs using partial correlation analysis controlling for LV volume, age, and sex. RESULTS: We found that HCs showed a significant negative correlation between the intraventricular BT and the local SBAs in the bilateral putamina and left superior temporal gyrus, while such a correlation was absent in AOSpatients. Additionally, no significant difference between the two groups was found in the intraventricular BT. CONCLUSION: These findings suggest that AOSpatients may experience an uncoupling between intraventricular BT and SBAs in several schizophrenia-related brain areas, which may be associated with the altered relationships among intraventricular BT, CBF, and metabolism.
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