Daichi Sone1, Miho Ota2, Kota Yokoyama3, Kaoru Sumida3, Yukio Kimura3, Etsuko Imabayashi4, Hiroshi Matsuda4, Noriko Sato5. 1. Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan; Department of Neuropsychiatry, Graduate School of Medicine, the University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo 113-8654, Japan. 2. Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. 3. Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan. 4. Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan. 5. Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan. Electronic address: snoriko@ncnp.go.jp.
Abstract
INTRODUCTION: In temporal lobe epilepsy (TLE), an uncoupling of cerebral blood flow (CBF) and metabolism is indicated. The aim of this study was to clarify this relationship by investigating intraventricular brain temperature (BT) and CBF in TLE using a noninvasive MRI technique. MATERIAL AND METHODS: We recruited 38 subjects with left TLE and 39 subjects with right TLE. All patients underwent an MRI examination including diffusion-weighted imaging (DWI) and pseudo-continuous arterial spin labeling (pCASL). Intraventricular BT was calculated by a DWI thermometric technique, and regional CBF was obtained from pCASL images, and we analyzed the relationship between them using the statistical parametric mapping 8 software (SPM8). RESULTS: In only the left TLE group, there was a significant negative correlation between CBF and BT in the left inferior frontal gyrus. Positive correlations in the bilateral posterior poles were also found at the trend level in left TLE group. The patients with right TLE showed no significant correlation. CONCLUSION: Our results may reflect a regional uncoupling of blood flow and metabolism in those brain areas, and they may indicate that TLE has different metabolic regulation systems in the brain.
INTRODUCTION: In temporal lobe epilepsy (TLE), an uncoupling of cerebral blood flow (CBF) and metabolism is indicated. The aim of this study was to clarify this relationship by investigating intraventricular brain temperature (BT) and CBF in TLE using a noninvasive MRI technique. MATERIAL AND METHODS: We recruited 38 subjects with left TLE and 39 subjects with right TLE. All patients underwent an MRI examination including diffusion-weighted imaging (DWI) and pseudo-continuous arterial spin labeling (pCASL). Intraventricular BT was calculated by a DWI thermometric technique, and regional CBF was obtained from pCASL images, and we analyzed the relationship between them using the statistical parametric mapping 8 software (SPM8). RESULTS: In only the left TLE group, there was a significant negative correlation between CBF and BT in the left inferior frontal gyrus. Positive correlations in the bilateral posterior poles were also found at the trend level in left TLE group. The patients with right TLE showed no significant correlation. CONCLUSION: Our results may reflect a regional uncoupling of blood flow and metabolism in those brain areas, and they may indicate that TLE has different metabolic regulation systems in the brain.