Literature DB >> 3084152

Enhanced tumor metastases upon drug delivery in cross-linked albumin beads.

M P Moyer, A Armstrong, J Parra, D Escobar.   

Abstract

Growth of the murine hepatoma H6 was significantly suppressed by amiloride, a sodium influx inhibitor. Primary tumor growth inhibition was augmented by loading the drug into cross-linked albumin carriers, but lung metastases were enhanced. These results emphasize the importance of using metastatic tumor models when testing new drugs and/or alternative modes of drug delivery.

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Year:  1986        PMID: 3084152     DOI: 10.1007/bf00053474

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN: 0262-0898            Impact factor:   5.150


  12 in total

1.  Antibodies as carriers for oncostatic materials.

Authors:  R Arnon; E Hurwitz; M Sela
Journal:  Recent Results Cancer Res       Date:  1980

2.  Transformation parameters induced in chick cells by incubation in media of altered NaCl concentration.

Authors:  R F Garry; M P Moyer; J M Bishop; R C Moyer; M R Waite
Journal:  Virology       Date:  1981-06       Impact factor: 3.616

3.  Insulin-albumin microbeads: an implantable, biodegradable system.

Authors:  M F Goosen; Y F Leung; S Chou; A M Sun
Journal:  Biomater Med Devices Artif Organs       Date:  1982

4.  In vitro block of murine L 1210 leukemia cell growth by amiloride, an inhibitor of passive Na+ influx.

Authors:  C Pieri; S Giunta; C Giuli; C Bertoni-Freddari; M Muzzioli
Journal:  Life Sci       Date:  1983-04-11       Impact factor: 5.037

5.  Preparation of hydrophilic albumin microspheres using polymeric dispersing agents.

Authors:  W E Longo; H Iwata; T A Lindheimer; E P Goldberg
Journal:  J Pharm Sci       Date:  1982-12       Impact factor: 3.534

6.  A survey of intracellular Na+ and K+ of various normal, transformed, and tumor cells.

Authors:  M P Moyer; R C Moyer; M R Waite
Journal:  J Cell Physiol       Date:  1982-10       Impact factor: 6.384

7.  Biodegradable serum albumin polymers for the sustained release of virus antigens in vaccines. A preliminary report.

Authors:  J B Dewar; D A Hendry; J F Newman
Journal:  S Afr Med J       Date:  1984-04-07

8.  Effects of amiloride on tumor growth and intracellular element content of tumor cells in vivo.

Authors:  R L Sparks; T B Pool; N K Smith; I L Cameron
Journal:  Cancer Res       Date:  1983-01       Impact factor: 12.701

Review 9.  Antibody-linked cytotoxic agents in the treatment of cancer: current status and future prospects.

Authors:  T Ghose; A H Blair
Journal:  J Natl Cancer Inst       Date:  1978-09       Impact factor: 13.506

10.  Slow release of insulin from a biodegradable matrix implanted in diabetic rats.

Authors:  M F Goosen; Y F Leung; G M O'Shea; S Chou; A M Sun
Journal:  Diabetes       Date:  1983-05       Impact factor: 9.461

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