| Literature DB >> 6835023 |
C Pieri, S Giunta, C Giuli, C Bertoni-Freddari, M Muzzioli.
Abstract
The present study was aimed to decide whether Na+ influx can be involved in regulation of murine L 1210 leukemia cell growth. Cells were cultivated in the presence of different concentrations of amiloride and cellular growth was monitored by 3H-thymidine incorporation/10(5) cells. This drug inhibited cell growth in concentrations ranging from 1 X 10(-5) to 1 X 10(-3) mmol/ml. Even short time treatments with amiloride caused irreversible alterations: the cells, although survived, lost their ability to divide. The results support the hypothesis that Na+ influx is necessary for the duplication of tumor cells.Entities:
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Year: 1983 PMID： 6835023 DOI： 10.1016/0024-3205(83)90842-1
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037