Aline Duarte Folle1, Kimberly C Paul1, Jeff M Bronstein2, Adrienne M Keener3, Beate Ritz4. 1. Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA. 2. Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA; Department of Neurology, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA, USA. 3. Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA. 4. Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA; Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA. Electronic address: britz@ucla.edu.
Abstract
INTRODUCTION: Rapid Eye Movement (REM) sleep behavior disorder (RBD) is characterized by dream enactment and is associated with incidence of neurodegenerative disorders, especially Parkinson's disease (PD). Whether PD with RBD constitutes a distinct subtype with unique progression is unknown. Here, we investigated motor and cognitive symptom progression in patients with self-reported RBD features in adult life. METHODS: We screened for RBD in a cohort of 776 PD patients whom we ascertained using a population-based strategy. Among participants with at least one follow-up (60%), we compared those with and without probable RBD (pRBD) estimating hazard rate ratios for progression events UPDRS-III≥ 35 and MMSE≤ 24. RESULTS: Prevalence of pRBD at baseline was 21%. In adjusted Cox regression models among patients with a Postural Instability and Gait Dysfunction (PIGD) phenotype, those with pRBD progressed faster to a UPDRS-III≥ 35 (HR = 1.92, 95% CI = 1.12; 3.27). Also, all patients with pRBD progressed twice as fast to a MMSE score≤ 24 (HR = 2.04, 95% CI = 1.13; 3.69). In sensitivity analyses, using alternative definition of pRBD and accounting for bias due to loss to follow-up results remained similar. DISCUSSION: Employing data from one of the largest population-based studies of PD, in which movement disorder specialists assessed patients, we confirm evidence that pRBD features are a clinical marker for faster cognitive decline and possibly also motor progression in PD patients, the latter for patients with a PIGD subtype early in disease.
INTRODUCTION:Rapid Eye Movement (REM) sleep behavior disorder (RBD) is characterized by dream enactment and is associated with incidence of neurodegenerative disorders, especially Parkinson's disease (PD). Whether PD with RBD constitutes a distinct subtype with unique progression is unknown. Here, we investigated motor and cognitive symptom progression in patients with self-reported RBD features in adult life. METHODS: We screened for RBD in a cohort of 776 PDpatients whom we ascertained using a population-based strategy. Among participants with at least one follow-up (60%), we compared those with and without probable RBD (pRBD) estimating hazard rate ratios for progression events UPDRS-III≥ 35 and MMSE≤ 24. RESULTS: Prevalence of pRBD at baseline was 21%. In adjusted Cox regression models among patients with a Postural Instability and Gait Dysfunction (PIGD) phenotype, those with pRBD progressed faster to a UPDRS-III≥ 35 (HR = 1.92, 95% CI = 1.12; 3.27). Also, all patients with pRBD progressed twice as fast to a MMSE score≤ 24 (HR = 2.04, 95% CI = 1.13; 3.69). In sensitivity analyses, using alternative definition of pRBD and accounting for bias due to loss to follow-up results remained similar. DISCUSSION: Employing data from one of the largest population-based studies of PD, in which movement disorder specialists assessed patients, we confirm evidence that pRBD features are a clinical marker for faster cognitive decline and possibly also motor progression in PDpatients, the latter for patients with a PIGD subtype early in disease.
Authors: S Lavault; S Leu-Semenescu; S Tezenas du Montcel; V Cochen de Cock; M Vidailhet; I Arnulf Journal: J Neurol Date: 2010-02-11 Impact factor: 4.849
Authors: Maria E Linn-Evans; Matthew N Petrucci; Sommer L Amundsen Huffmaster; Jae Woo Chung; Paul J Tuite; Michael J Howell; Aleksandar Videnovic; Colum D MacKinnon Journal: Clin Neurophysiol Date: 2020-05-12 Impact factor: 3.708
Authors: Ryan Van Patten; Zanjbeel Mahmood; Delaney Pickell; Jacqueline E Maye; Scott Roesch; Elizabeth W Twamley; J Vincent Filoteo; Dawn M Schiehser Journal: Arch Clin Neuropsychol Date: 2022-01-17 Impact factor: 3.448
Authors: Lilian Calderón-Garcidueñas; Ravi Philip Rajkumar; Elijah W Stommel; Randy Kulesza; Yusra Mansour; Adriana Rico-Villanueva; Jorge Orlando Flores-Vázquez; Rafael Brito-Aguilar; Silvia Ramírez-Sánchez; Griselda García-Alonso; Diana A Chávez-Franco; Samuel C Luévano-Castro; Edgar García-Rojas; Paula Revueltas-Ficachi; Rodolfo Villarreal-Ríos; Partha S Mukherjee Journal: Int J Environ Res Public Health Date: 2021-06-22 Impact factor: 3.390