Jun Zhu1, Liyu Lu1, Min Zhong1, Xu Jiang1, Zhuang Wu1, Jingde Dong1, Yang Pan1, Li Zhang2. 1. Department of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, 264 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China. 2. Department of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, 264 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China. njmuzhangli@sina.com.
Abstract
OBJECTIVE: Impaired rapid eye movement sleep is common among patients with Parkinson's disease (PD). However, information on rapid eye movement density (REM) among PD patients is currently lacking. The current study sought to characterize REM density in PD patients and to examine the associations between REM density sleep parameters and clinical manifestations. PARTICIPANTS AND METHODS: We retrospectively recruited 172 PD patients. All participants were assessed with a two-night polysomnography, and REM density was calculated. Clinical assessments were completed in PD patients before polysomnography. RESULTS: Rapid eye movement sleep behavior disorder (RBD) was observed in 93 patients (54.1%). The disease duration, UPDRS part III score, Hoehn and Yahr (H-Y) stage, and HAMA, HAMD, PDQ-39 scores, and REM density in the Parkinson's disease patients with rapid eye movement sleep behavior disorder (RBD) were significantly higher than in the patients without RBD (P < 0.05). However, NREM sleep stage 3 time (N3 time) and percentage of N3 time of total sleep time (N3%) were significantly lower in the RBD patients than in the patients without RBD (P < 0.05). The forward binary logistic regression model showed that REM density, UPDRS-III score, and N3 sleep time were associated with RBD in the PD patients. CONCLUSIONS: Our results confirm the high prevalence of RBD in patients with PD. Increased REM density was the main risk factor of RBD.
OBJECTIVE: Impaired rapid eye movement sleep is common among patients with Parkinson's disease (PD). However, information on rapid eye movement density (REM) among PDpatients is currently lacking. The current study sought to characterize REM density in PDpatients and to examine the associations between REM density sleep parameters and clinical manifestations. PARTICIPANTS AND METHODS: We retrospectively recruited 172 PDpatients. All participants were assessed with a two-night polysomnography, and REM density was calculated. Clinical assessments were completed in PDpatients before polysomnography. RESULTS: Rapid eye movement sleep behavior disorder (RBD) was observed in 93 patients (54.1%). The disease duration, UPDRS part III score, Hoehn and Yahr (H-Y) stage, and HAMA, HAMD, PDQ-39 scores, and REM density in the Parkinson's diseasepatients with rapid eye movement sleep behavior disorder (RBD) were significantly higher than in the patients without RBD (P < 0.05). However, NREM sleep stage 3 time (N3 time) and percentage of N3 time of total sleep time (N3%) were significantly lower in the RBD patients than in the patients without RBD (P < 0.05). The forward binary logistic regression model showed that REM density, UPDRS-III score, and N3 sleep time were associated with RBD in the PDpatients. CONCLUSIONS: Our results confirm the high prevalence of RBD in patients with PD. Increased REM density was the main risk factor of RBD.
Entities:
Keywords:
Parkinson’s disease; Polysomnography; RBD; REM density