OBJECTIVE: To determine the estimates of minimal, moderate, and large clinically important differences (CIDs) for the Unified Parkinson's Disease Rating Scale (UPDRS). DESIGN: Cross-sectional analysis of the CIDs for UPDRS total and motor scores was performed on patients with Parkinson disease (PD) using distribution- and anchor-based approaches based on the following 3 external standards: disability (10% on the Schwab and England Activities of Daily Living Scale), disease stage (1 stage on the Hoehn and Yahr Scale), and quality of life (1 SD on the 12-Item Short Form Health Survey). SETTING: University of Maryland Parkinson Disease and Movement Disorders Center, Patients Six hundred fifty-three patients with PD. RESULTS: A minimal CID was 2.3 to 2.7 points on the UPDRS motor score and 4.1 to 4.5 on the UPDRS total score. A moderate CID was 4.5 to 6.7 points on the UPDRS motor score and 8.5 to 10.3 on the UPDRS total score. A large CID was 10.7 to 10.8 points on the UPDRS motor score and 16.4 to 17.8 on the UPDRS total score. CONCLUSIONS: Concordance among multiple approaches of analysis based on subjective and objective data show that reasonable estimates for the CID on the UPDRS motor score are 2.5 points for minimal, 5.2 for moderate, and 10.8 for large CIDs. Estimates for the UPDRS total score are 4.3 points for minimal, 9.1 for moderate, and 17.1 for large CIDs. These estimates will assist in determining clinically meaningful changes in PD progression and response to therapeutic interventions.
OBJECTIVE: To determine the estimates of minimal, moderate, and large clinically important differences (CIDs) for the Unified Parkinson's Disease Rating Scale (UPDRS). DESIGN: Cross-sectional analysis of the CIDs for UPDRS total and motor scores was performed on patients with Parkinson disease (PD) using distribution- and anchor-based approaches based on the following 3 external standards: disability (10% on the Schwab and England Activities of Daily Living Scale), disease stage (1 stage on the Hoehn and Yahr Scale), and quality of life (1 SD on the 12-Item Short Form Health Survey). SETTING: University of Maryland Parkinson Disease and Movement Disorders Center, Patients Six hundred fifty-three patients with PD. RESULTS: A minimal CID was 2.3 to 2.7 points on the UPDRS motor score and 4.1 to 4.5 on the UPDRS total score. A moderate CID was 4.5 to 6.7 points on the UPDRS motor score and 8.5 to 10.3 on the UPDRS total score. A large CID was 10.7 to 10.8 points on the UPDRS motor score and 16.4 to 17.8 on the UPDRS total score. CONCLUSIONS: Concordance among multiple approaches of analysis based on subjective and objective data show that reasonable estimates for the CID on the UPDRS motor score are 2.5 points for minimal, 5.2 for moderate, and 10.8 for large CIDs. Estimates for the UPDRS total score are 4.3 points for minimal, 9.1 for moderate, and 17.1 for large CIDs. These estimates will assist in determining clinically meaningful changes in PD progression and response to therapeutic interventions.
Authors: Carla Silva-Batista; Andrea Cristina de Lima-Pardini; Mariana Penteado Nucci; Daniel Boari Coelho; Alana Batista; Maria Elisa Pimentel Piemonte; Egberto Reis Barbosa; Luis Augusto Teixeira; Daniel M Corcos; Edson Amaro; Fay B Horak; Carlos Ugrinowitsch Journal: Mov Disord Date: 2020-06-18 Impact factor: 10.338
Authors: Aparna Wagle Shukla; Jonathan J Shuster; Jae Woo Chung; David E Vaillancourt; Carolynn Patten; Jill Ostrem; Michael S Okun Journal: PM R Date: 2015-08-24 Impact factor: 2.298
Authors: James T Cavanaugh; Terry D Ellis; Gammon M Earhart; Matthew P Ford; K Bo Foreman; Leland E Dibble Journal: J Neurol Phys Ther Date: 2012-06 Impact factor: 3.649
Authors: Martin Niethammer; Chris C Tang; Peter A LeWitt; Ali R Rezai; Maureen A Leehey; Steven G Ojemann; Alice W Flaherty; Emad N Eskandar; Sandra K Kostyk; Atom Sarkar; Mustafa S Siddiqui; Stephen B Tatter; Jason M Schwalb; Kathleen L Poston; Jaimie M Henderson; Roger M Kurlan; Irene H Richard; Christine V Sapan; David Eidelberg; Matthew J During; Michael G Kaplitt; Andrew Feigin Journal: JCI Insight Date: 2017-04-06
Authors: Shinichi Amano; Joe R Nocera; Srikant Vallabhajosula; Jorge L Juncos; Robert J Gregor; Dwight E Waddell; Steven L Wolf; Chris J Hass Journal: Parkinsonism Relat Disord Date: 2013-07-05 Impact factor: 4.891
Authors: Claire L Tomlinson; Clare P Herd; Carl E Clarke; Charmaine Meek; Smitaa Patel; Rebecca Stowe; Katherine H O Deane; Laila Shah; Catherine M Sackley; Keith Wheatley; Natalie Ives Journal: Cochrane Database Syst Rev Date: 2014-06-17
Authors: Daniel M Corcos; Julie A Robichaud; Fabian J David; Sue E Leurgans; David E Vaillancourt; Cynthia Poon; Miriam R Rafferty; Wendy M Kohrt; Cynthia L Comella Journal: Mov Disord Date: 2013-03-27 Impact factor: 10.338