Computer simulation of mammalian gas-exchange.

Gas exchange efficiency is dependent upon the distribution of ventilation to perfusion throughout the lung, as well as the position and shape of the oxygen and carbon dioxide dissociation curves, and the composition of mixed venous blood. Computer simulation has allowed practical investigation of these relationships. A BASIC program suitable for small microcomputers is presented which calculates the arterial blood gases and gas transport corresponding to an arbitrary VA/Q distribution and mixed venous composition. The needed theory and equations are developed, the program is discussed, and an example is presented.