Literature DB >> 31577170

Ventilation/Perfusion Matching: Of Myths, Mice, and Men.

Alys R Clark1, Kelly S Burrowes1, Merryn H Tawhai1.   

Abstract

Despite a huge range in lung size between species, there is little measured difference in the ability of the lung to provide a well-matched air flow (ventilation) to blood flow (perfusion) at the gas exchange tissue. Here, we consider the remarkable similarities in ventilation/perfusion matching between species through a biophysical lens and consider evidence that matching in large animals is dominated by gravity but in small animals by structure.

Entities:  

Keywords:  computational models; lungs; perfusion; ventilation

Mesh：

Year:  2019        PMID： 31577170      PMCID： PMC7002871          DOI： 10.1152/physiol.00016.2019

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  78 in total

1.  Increase in pulmonary ventilation-perfusion inequality with age in healthy individuals.

Authors:  J Cardús; F Burgos; O Diaz; J Roca; J A Barberà; R M Marrades; R Rodriguez-Roisin; P D Wagner
Journal:  Am J Respir Crit Care Med       Date:  1997-08       Impact factor: 21.405

Review 2.  Factors that affect the efficacy of inhaled corticosteroids for infants and young children.

Authors:  Israel Amirav; Michael T Newhouse; Stefan Minocchieri; Jose A Castro-Rodriguez; Karen G Schüepp
Journal:  J Allergy Clin Immunol       Date:  2010-03-24       Impact factor: 10.793

3.  Lack of functional information explains the poor performance of 'clot load scores' at predicting outcome in acute pulmonary embolism.

Authors:  A R Clark; D Milne; M Wilsher; K S Burrowes; M Bajaj; M H Tawhai
Journal:  Respir Physiol Neurobiol       Date:  2013-09-27       Impact factor: 1.931

4.  Distribution of ventilation-perfusion ratios in dogs with normal and abnormal lungs.

Authors:  P D Wagner; R B Laravuso; E Goldzimmer; P F Naumann; J B West
Journal:  J Appl Physiol       Date:  1975-06       Impact factor: 3.531

5.  Pulmonary gas-exchange analysis by using simultaneous deposition of aerosolized and injected microspheres.

Authors:  W A Altemeier; H T Robertson; R W Glenny
Journal:  J Appl Physiol (1985)       Date:  1998-12

6.  Identifying airways responsible for heterogeneous ventilation and mechanical dysfunction in asthma: an image functional modeling approach.

Authors:  Nora T Tgavalekos; Merryn Tawhai; R Scott Harris; Guido Musch; Guido Mush; Marcos Vidal-Melo; Jose G Venegas; Kenneth R Lutchen
Journal:  J Appl Physiol (1985)       Date:  2005-08-04

7.  Contributions of pulmonary perfusion and ventilation to heterogeneity in V(A)/Q measured by PET.

Authors:  S Treppo; S M Mijailovich; J G Venegas
Journal:  J Appl Physiol (1985)       Date:  1997-04

8.  Analysis of regional mechanics in canine lung injury using forced oscillations and 3D image registration.

Authors:  David W Kaczka; Kunlin Cao; Gary E Christensen; Jason H T Bates; Brett A Simon
Journal:  Ann Biomed Eng       Date:  2010-12-04       Impact factor: 3.934

9.  Oxygen-induced alteration of ventilation-perfusion relationships in rats.

Authors:  W E Truog; M P Hlastala; T A Standaert; H P McKenna; W A Hodson
Journal:  J Appl Physiol Respir Environ Exerc Physiol       Date:  1979-11

10.  Gravity outweighs the contribution of structure to passive ventilation-perfusion matching in the supine adult human lung.

Authors:  W Kang; A R Clark; M H Tawhai
Journal:  J Appl Physiol (1985)       Date:  2017-10-19
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  2 in total

1.  3D Magnetic Resonance Spirometry.

Authors:  Tanguy Boucneau; Brice Fernandez; Peder Larson; Luc Darrasse; Xavier Maître
Journal:  Sci Rep       Date:  2020-06-15       Impact factor: 4.379

2.  Three-Dimensional Whole-Organ Characterization of the Regional Alveolar Morphology in Normal Murine Lungs.

Authors:  Mauricio A Sarabia-Vallejos; Pedro Ayala-Jeria; Daniel E Hurtado
Journal:  Front Physiol       Date:  2021-12-08       Impact factor: 4.566
  2 in total

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