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Literature DB >> 3082329

Enzymic imbalance in serine metabolism in rat hepatomas.

Abstract

The activity of 3-phosphoglycerate dehydrogenase was high in tissues of high cell-renewal capacity, and was increased in neonatal and regenerating liver and, more markedly, in hepatomas. Serine hydroxymethyltransferase activity was present in hepatomas, whereas other enzymes of serine utilization (serine dehydratase and serine aminotransferase) were absent. This enzymic imbalance couples serine biosynthesis preferentially to nucleotide precursor formation in cancer cells.

Entities: Chemical Disease Gene Species

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Year: 1986 PMID： 3082329 PMCID： PMC1153072 DOI： 10.1042/bj2330617

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

12 in total

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Journal: Biochem J Date: 1980-08-15 Impact factor: 3.857

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Authors: K Snell
Journal: Adv Enzyme Regul Date: 1984

35 in total

1. Gene expression differences of regenerating rat liver in a short interval successive partial hepatectomy.

Authors: Cun-Shuan Xu; An-Shi Zhang; Hong-Peng Han; Jin-Yun Yuan; Cui-Fang Chang; Wen-Qiang Li; Ke-Jin Yang; Li-Feng Zhao; Yu-Chang Li; Hui-Yong Zhang; Salman Rahman; Jing-Bo Zhang
Journal: World J Gastroenterol Date: 2004-09-15 Impact factor: 5.742

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Authors: Christian Frezza
Journal: Nat Chem Biol Date: 2016-05-18 Impact factor: 15.040

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Authors: D A Fell; K Snell
Journal: Biochem J Date: 1988-11-15 Impact factor: 3.857

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Authors: K Snell; Y Natsumeda; G Weber
Journal: Biochem J Date: 1987-07-15 Impact factor: 3.857

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Authors: L W Klomp; T J de Koning; H E Malingré; E A van Beurden; M Brink; F L Opdam; M Duran; J Jaeken; M Pineda; L Van Maldergem; B T Poll-The; I E van den Berg; R Berger
Journal: Am J Hum Genet Date: 2000-10-27 Impact factor: 11.025

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Journal: World J Biol Chem Date: 2015-11-26

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9. Requirement of the expression of 3-phosphoglycerate dehydrogenase for traversing S phase in murine T lymphocytes following immobilized anti-CD3 activation.

Authors: Do Youn Jun; Dennis Taub; Francis J Chrest; Young Ho Kim
Journal: Cell Immunol Date: 2013-12-18 Impact factor: 4.868

10. 3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells.

Authors: Hongling Du; Danielle Vitiello; Jennifer L Sarno; Hugh S Taylor
Journal: Reproduction Date: 2010-01 Impact factor: 3.906