Literature DB >> 27191646

Cancer metabolism: Addicted to serine.

Christian Frezza1.   

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Year:  2016        PMID： 27191646     DOI： 10.1038/nchembio.2086

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  8 in total

1.  Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

Authors:  Jason W Locasale; Alexandra R Grassian; Tamar Melman; Costas A Lyssiotis; Katherine R Mattaini; Adam J Bass; Gregory Heffron; Christian M Metallo; Taru Muranen; Hadar Sharfi; Atsuo T Sasaki; Dimitrios Anastasiou; Edouard Mullarky; Natalie I Vokes; Mika Sasaki; Rameen Beroukhim; Gregory Stephanopoulos; Azra H Ligon; Matthew Meyerson; Andrea L Richardson; Lynda Chin; Gerhard Wagner; John M Asara; Joan S Brugge; Lewis C Cantley; Matthew G Vander Heiden
Journal:  Nat Genet       Date:  2011-07-31       Impact factor: 38.330

2.  Enzymic imbalance in serine metabolism in rat hepatomas.

Authors:  K Snell; G Weber
Journal:  Biochem J       Date:  1986-01-15       Impact factor: 3.857

3.  Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells.

Authors:  Aaron M Hosios; Vivian C Hecht; Laura V Danai; Marc O Johnson; Jeffrey C Rathmell; Matthew L Steinhauser; Scott R Manalis; Matthew G Vander Heiden
Journal:  Dev Cell       Date:  2016-03-07       Impact factor: 12.270

4.  Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

Authors:  Edouard Mullarky; Natasha C Lucki; Reza Beheshti Zavareh; Justin L Anglin; Ana P Gomes; Brandon N Nicolay; Jenny C Y Wong; Stefan Christen; Hidenori Takahashi; Pradeep K Singh; John Blenis; J David Warren; Sarah-Maria Fendt; John M Asara; Gina M DeNicola; Costas A Lyssiotis; Luke L Lairson; Lewis C Cantley
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-01       Impact factor: 11.205

5.  Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Authors:  Richard Possemato; Kevin M Marks; Yoav D Shaul; Michael E Pacold; Dohoon Kim; Kıvanç Birsoy; Shalini Sethumadhavan; Hin-Koon Woo; Hyun G Jang; Abhishek K Jha; Walter W Chen; Francesca G Barrett; Nicolas Stransky; Zhi-Yang Tsun; Glenn S Cowley; Jordi Barretina; Nada Y Kalaany; Peggy P Hsu; Kathleen Ottina; Albert M Chan; Bingbing Yuan; Levi A Garraway; David E Root; Mari Mino-Kenudson; Elena F Brachtel; Edward M Driggers; David M Sabatini
Journal:  Nature       Date:  2011-08-18       Impact factor: 49.962

6.  Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.

Authors:  Jing Fan; Xin Teng; Ling Liu; Katherine R Mattaini; Ryan E Looper; Matthew G Vander Heiden; Joshua D Rabinowitz
Journal:  ACS Chem Biol       Date:  2014-11-18       Impact factor: 5.100

7.  NRF2 regulates serine biosynthesis in non-small cell lung cancer.

Authors:  Gina M DeNicola; Pei-Hsuan Chen; Edouard Mullarky; Jessica A Sudderth; Zeping Hu; David Wu; Hao Tang; Yang Xie; John M Asara; Kenneth E Huffman; Ignacio I Wistuba; John D Minna; Ralph J DeBerardinis; Lewis C Cantley
Journal:  Nat Genet       Date:  2015-10-19       Impact factor: 38.330

8.  A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Authors:  Michael E Pacold; Kyle R Brimacombe; Sze Ham Chan; Jason M Rohde; Caroline A Lewis; Lotteke J Y M Swier; Richard Possemato; Walter W Chen; Lucas B Sullivan; Brian P Fiske; Steve Cho; Elizaveta Freinkman; Kıvanç Birsoy; Monther Abu-Remaileh; Yoav D Shaul; Chieh Min Liu; Minerva Zhou; Min Jung Koh; Haeyoon Chung; Shawn M Davidson; Alba Luengo; Amy Q Wang; Xin Xu; Adam Yasgar; Li Liu; Ganesha Rai; Kenneth D Westover; Matthew G Vander Heiden; Min Shen; Nathanael S Gray; Matthew B Boxer; David M Sabatini
Journal:  Nat Chem Biol       Date:  2016-04-25       Impact factor: 15.040
  8 in total
  8 in total

1.  PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma.

Authors:  Hirofumi Yoshino; Nijiro Nohata; Kazutaka Miyamoto; Masaya Yonemori; Takashi Sakaguchi; Satoshi Sugita; Toshihiko Itesako; Satoshi Kofuji; Masayuki Nakagawa; Rajvir Dahiya; Hideki Enokida
Journal:  Cancer Res       Date:  2017-09-26       Impact factor: 12.701

Review 2.  3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment.

Authors:  Mingxue Li; Canrong Wu; Yueying Yang; Mengzhu Zheng; Silin Yu; Jinhui Wang; Lixia Chen; Hua Li
Journal:  Cell Oncol (Dordr)       Date:  2021-03-18       Impact factor: 6.730

Review 3.  The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code.

Authors:  Milica Vučetić; Yann Cormerais; Scott K Parks; Jacques Pouysségur
Journal:  Front Oncol       Date:  2017-12-21       Impact factor: 6.244

Review 4.  Oncology Therapeutics Targeting the Metabolism of Amino Acids.

Authors:  Nefertiti Muhammad; Hyun Min Lee; Jiyeon Kim
Journal:  Cells       Date:  2020-08-15       Impact factor: 6.600

5.  PHGDH as a mechanism for resistance in metabolically-driven cancers.

Authors:  Richa Rathore; Charles R Schutt; Brian A Van Tine
Journal:  Cancer Drug Resist       Date:  2020-09-17

6.  Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism.

Authors:  Wei Han; Shanshan Wang; Yingjiao Qi; Fan Wu; Ningyu Tian; Boqin Qiang; Xiaozhong Peng
Journal:  iScience       Date:  2022-07-31

7.  Serum Serine and the Risk of All-Cause Mortality: A Nested Case-Control Study From the China Stroke Primary Prevention Trial (CSPPT).

Authors:  Qiangqiang He; Nan Zhang; Qiongyue Liang; Zhuo Wang; Ping Chen; Yun Song; Ziyi Zhou; Yaping Wei; Yong Duan; Binyan Wang; Peiwu Qin; Xianhui Qin; Xiping Xu
Journal:  Front Nutr       Date:  2022-07-12

8.  Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells.

Authors:  Tanveer Sharif; Emma Martell; Cathleen Dai; Mohammad Saleh Ghassemi-Rad; Kristen Lee; Sheila K Singh; Ian C G Weaver; Shashi Gujar
Journal:  Cell Death Dis       Date:  2018-09-24       Impact factor: 8.469
  8 in total

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