Literature DB >> 6794659

The role of serine hydroxymethyltransferase in cell proliferation: DNA synthesis from serine following mitogenic stimulation of lymphocytes.

H G Eichler, R Hubbard, K Snell.   

Abstract

It is shown that the time-course of incorporation of radioactivity from [3-14C]serine into nucleic acids parallels DNA synthesis following mitogenic stimulation of human peripheral blood lymphocytes by phytohaemagglutinin (PHA). The activity of serine hydroxymethyltransferase was elevated about four-fold in PHA-stimulated lymphocytes compared to that in unstimulated control cells. It is suggested that lymphocytes, in common with other proliferating cell systems, may synthesize serine de novo for utilization in pathways of nucleotide biosynthesis following mitogenic stimulation.

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Year:  1981        PMID： 6794659     DOI： 10.1007/BF01117006

Source DB:  PubMed          Journal:  Biosci Rep        ISSN： 0144-8463            Impact factor:   3.840


  13 in total

1.  Asp-89: a critical residue in maintaining the oligomeric structure of sheep liver cytosolic serine hydroxymethyltransferase.

Authors:  J V Krishna Rao; J R Jagath; B Sharma; N Appaji Rao; H S Savithri
Journal:  Biochem J       Date:  1999-10-01       Impact factor: 3.857

2.  Nucleotide sequence and expression of a cDNA encoding rabbit liver cytosolic serine hydroxymethyltransferase.

Authors:  P C Byrne; P G Sanders; K Snell
Journal:  Biochem J       Date:  1992-08-15       Impact factor: 3.857

3.  Role of Arg-401 of cytosolic serine hydroxymethyltransferase in subunit assembly and interaction with the substrate carboxy group.

Authors:  J R Jagath; N A Rao; H S Savithri
Journal:  Biochem J       Date:  1997-11-01       Impact factor: 3.857

4.  Enzymic imbalance in serine metabolism in rat hepatomas.

Authors:  K Snell; G Weber
Journal:  Biochem J       Date:  1986-01-15       Impact factor: 3.857

5.  Control analysis of mammalian serine biosynthesis. Feedback inhibition on the final step.

Authors:  D A Fell; K Snell
Journal:  Biochem J       Date:  1988-11-15       Impact factor: 3.857

6.  The modulation of serine metabolism in hepatoma 3924A during different phases of cellular proliferation in culture.

Authors:  K Snell; Y Natsumeda; G Weber
Journal:  Biochem J       Date:  1987-07-15       Impact factor: 3.857

7.  The phosphorylated pathway of serine biosynthesis is essential both for male gametophyte and embryo development and for root growth in Arabidopsis.

Authors:  Borja Cascales-Miñana; Jesús Muñoz-Bertomeu; María Flores-Tornero; Armand Djoro Anoman; José Pertusa; Manuel Alaiz; Sonia Osorio; Alisdair R Fernie; Juan Segura; Roc Ros
Journal:  Plant Cell       Date:  2013-06-14       Impact factor: 11.277

8.  Haploinsufficiency of cytosolic serine hydroxymethyltransferase in the Smith-Magenis syndrome.

Authors:  S H Elsea; R C Juyal; S Jiralerspong; B M Finucane; M Pandolfo; F Greenberg; A Baldini; P Stover; P I Patel
Journal:  Am J Hum Genet       Date:  1995-12       Impact factor: 11.025

9.  Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation.

Authors:  Alexei Vazquez; Elke K Markert; Zoltán N Oltvai
Journal:  PLoS One       Date:  2011-11-02       Impact factor: 3.240

10.  Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization.

Authors:  Wichai Pornthanakasem; Darin Kongkasuriyachai; Chairat Uthaipibull; Yongyuth Yuthavong; Ubolsree Leartsakulpanich
Journal:  Malar J       Date:  2012-11-22       Impact factor: 2.979
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