Literature DB >> 30820814

Simulated microgravity inhibits the viability and migration of glioma via FAK/RhoA/Rock and FAK/Nek2 signaling.

Banglian Deng1,2, Rongrong Liu3, Xin Tian4, Zucheng Han5, Jun Chen6.   

Abstract

Due to excessive proliferation and metastasis, glioma is the most common primary tumor in the central nervous system. Previous reports show simulated microgravity (SMG) has the ability to inhibit the proliferation and migration of cancer. The aim of this study was to evaluate the viability and migration of U251 cells in SMG environment. SMG induced apoptosis of U251 cells. The FAK/RhoA/Rock and FAK/Nek2 signaling events were attenuated by SMG to destabilize actin cytoskeleton and centrosome disjunction, which caused G2/M arrest and inhibition of cell viability and migration. Overexpressed FAK reversed SMG-induced inhibition of viability and migration in U251 cells, which increased downstream RhoA/Rock signaling and Nek2. These findings reveal novel pathways of FAK/RhoA/Rock and FAK/Nek2 are affected by SMG, and highlight an opportunity to expand therapeutic options in a variety of settings.

Entities:  

Keywords:  FAK; Glioma; Nek2; RhoA/Rock; Simulated microgravity

Mesh：

Substances：

Year:  2019        PMID： 30820814     DOI： 10.1007/s11626-019-00334-7

Source DB:  PubMed          Journal:  In Vitro Cell Dev Biol Anim        ISSN： 1071-2690            Impact factor:   2.416


  9 in total

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Journal:  Int J Mol Sci       Date:  2022-07-05       Impact factor: 6.208

2.  Activation of Focal Adhesion Kinase Restores Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation via Wnt/Β-Catenin Pathway.

Authors:  Cuihong Fan; Zhaojia Wu; David M L Cooper; Adam Magnus; Kim Harrison; B Frank Eames; Rajni Chibbar; Gary Groot; Junqiong Huang; Harald Genth; Jun Zhang; Xing Tan; Yulin Deng; Jim Xiang
Journal:  Int J Mol Sci       Date:  2022-05-17       Impact factor: 6.208

Review 3.  Microgravity, Stem Cells, and Cancer: A New Hope for Cancer Treatment.

Authors:  Uğur Topal; Cihan Zamur
Journal:  Stem Cells Int       Date:  2021-04-29       Impact factor: 5.443

Review 4.  The Impact of Spaceflight and Simulated Microgravity on Cell Adhesion.

Authors:  Xiao Lin; Kewen Zhang; Daixu Wei; Ye Tian; Yongguang Gao; Zhihao Chen; Airong Qian
Journal:  Int J Mol Sci       Date:  2020-04-25       Impact factor: 5.923

Review 5.  Influence of Microgravity on Apoptosis in Cells, Tissues, and Other Systems In Vivo and In Vitro.

Authors:  Binod Prasad; Daniela Grimm; Sebastian M Strauch; Gilmar Sidnei Erzinger; Thomas J Corydon; Michael Lebert; Nils E Magnusson; Manfred Infanger; Peter Richter; Marcus Krüger
Journal:  Int J Mol Sci       Date:  2020-12-09       Impact factor: 5.923

6.  Alterations of Growth and Focal Adhesion Molecules in Human Breast Cancer Cells Exposed to the Random Positioning Machine.

Authors:  Jayashree Sahana; Thomas J Corydon; Markus Wehland; Marcus Krüger; Sascha Kopp; Daniela Melnik; Stefan Kahlert; Borna Relja; Manfred Infanger; Daniela Grimm
Journal:  Front Cell Dev Biol       Date:  2021-06-30

Review 7.  Breast Cancer Cells in Microgravity: New Aspects for Cancer Research.

Authors:  Mohamed Zakaria Nassef; Daniela Melnik; Sascha Kopp; Jayashree Sahana; Manfred Infanger; Ronald Lützenberg; Borna Relja; Markus Wehland; Daniela Grimm; Marcus Krüger
Journal:  Int J Mol Sci       Date:  2020-10-05       Impact factor: 5.923

Review 8.  Cancer Studies under Space Conditions: Finding Answers Abroad.

Authors:  José Luis Cortés-Sánchez; Jonas Callant; Marcus Krüger; Jayashree Sahana; Armin Kraus; Bjorn Baselet; Manfred Infanger; Sarah Baatout; Daniela Grimm
Journal:  Biomedicines       Date:  2021-12-23

9.  Simulated Microgravity Induces the Proliferative Inhibition and Morphological Changes in Porcine Granulosa Cells.

Authors:  Truong Xuan Dai; Hoang Nghia Son; Ho Nguyen Quynh Chi; Hoang Nghia Quang Huy; Nguyen Thai Minh; Nguyen Thi Thuy Tram; Nguyen Thi Thuong Huyen; To Minh Quan; Doan Chinh Chung; Truong Hai Nhung; Tran Thi Minh; Tran Hong Diem; Nguyen Thi Phuong Mai; Le Thanh Long
Journal:  Curr Issues Mol Biol       Date:  2021-12-10       Impact factor: 2.976
  9 in total

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