A H E Küçükdiler1, M Varlı, Ö Yavuz, A Yalçın, H Selvi Öztorun, E Devrim, S Aras. 1. Ahmet Yalçın, Department of Geriatric Medicine, Ataturk's Research and Training Hospital, Eskibağlar Street, No:47, Safir Life apartments, A block flat no:14, Bağlıca, Etimesgut, Ankara, Turkey, e-mail: ahmetemreyalcin@hotmail.com, Telephone number: +90 533 254 54 45.
Abstract
OBJECTIVES: Oxidative stress may play a role in the pathogenesis of both sarcopenia and diabetes. Although the risk of sarcopenia is increased in people with type 2 diabetes, the relationship between sarcopenia oxidative stress and antioxidant status among the older diabetes population is not well studied. The aim of this present study was to evaluate the relationship between oxidative stress and antioxidant status and sarcopenia in elderly diabetic patients. DESIGN: This was a cross-sectional designed study with a control group. A total of 60 type 2 diabetic elderly patients were enrolled in the study (30 sarcopenic and 30 controls). MEASUREMENTS: Comprehensive geriatric assessments and anthropometric measurements were performed. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People. Skeletal muscle mass was measured using bioelectrical impedance analysis. A handheld dynamometer was used for skeletal muscle strength measurements. Gait speed was measured using a 4 meter walking test. Plasma malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and erythrocyte MDA, GSH-Px, superoxide dismutase (SOD), catalase and xanthine oxidase (XO) measurements were performed. RESULTS: While plasma XO was significantly higher in sarcopenic individuals (0.406(0.225-0.775)) compared to controls (0.312(0.112-0.712)) (p=0.006), plasma GSH-Px was significantly lower in sarcopenic individuals (0.154(0.101-0.274)) compared to controls (0.204(0.12-.0312)) (p=0.003). Plasma XO (OR: 2.69 (CI 95% 0.13-52.76, p=0.041) and BMI (OR: 0.6 (CI 95% 0.41-0.89, p=0.009) were independently associated with sarcopenia of diabetes in multivariate analysis. CONCLUSIONS: Only plasma XO was found to be independently associated with sarcopenia. XO can be important in the pathogenesis of sarcopenia in diabetes. Oxidative stress and antioxidant status might be associated with sarcopenia in diabetic older individuals but this association seems to be mediated by other factors. Further studies are needed on this subject.
OBJECTIVES:Oxidative stress may play a role in the pathogenesis of both sarcopenia and diabetes. Although the risk of sarcopenia is increased in people with type 2 diabetes, the relationship between sarcopeniaoxidative stress and antioxidant status among the older diabetes population is not well studied. The aim of this present study was to evaluate the relationship between oxidative stress and antioxidant status and sarcopenia in elderly diabeticpatients. DESIGN: This was a cross-sectional designed study with a control group. A total of 60 type 2 diabetic elderly patients were enrolled in the study (30 sarcopenic and 30 controls). MEASUREMENTS: Comprehensive geriatric assessments and anthropometric measurements were performed. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People. Skeletal muscle mass was measured using bioelectrical impedance analysis. A handheld dynamometer was used for skeletal muscle strength measurements. Gait speed was measured using a 4 meter walking test. Plasma malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and erythrocyte MDA, GSH-Px, superoxide dismutase (SOD), catalase and xanthine oxidase (XO) measurements were performed. RESULTS: While plasma XO was significantly higher in sarcopenic individuals (0.406(0.225-0.775)) compared to controls (0.312(0.112-0.712)) (p=0.006), plasma GSH-Px was significantly lower in sarcopenic individuals (0.154(0.101-0.274)) compared to controls (0.204(0.12-.0312)) (p=0.003). Plasma XO (OR: 2.69 (CI 95% 0.13-52.76, p=0.041) and BMI (OR: 0.6 (CI 95% 0.41-0.89, p=0.009) were independently associated with sarcopenia of diabetes in multivariate analysis. CONCLUSIONS: Only plasma XO was found to be independently associated with sarcopenia. XO can be important in the pathogenesis of sarcopenia in diabetes. Oxidative stress and antioxidant status might be associated with sarcopenia in diabetic older individuals but this association seems to be mediated by other factors. Further studies are needed on this subject.
Authors: Rafael H Lambertucci; Adriana Cristina Levada-Pires; Luciana V Rossoni; Rui Curi; Tania C Pithon-Curi Journal: Mech Ageing Dev Date: 2006-12-23 Impact factor: 5.432
Authors: Seok Won Park; Bret H Goodpaster; Elsa S Strotmeyer; Lewis H Kuller; Robert Broudeau; Candace Kammerer; Nathalie de Rekeneire; Tamara B Harris; Ann V Schwartz; Frances A Tylavsky; Yong-wook Cho; Anne B Newman Journal: Diabetes Care Date: 2007-03-15 Impact factor: 19.112
Authors: Seok Won Park; Bret H Goodpaster; Elsa S Strotmeyer; Nathalie de Rekeneire; Tamara B Harris; Ann V Schwartz; Frances A Tylavsky; Anne B Newman Journal: Diabetes Date: 2006-06 Impact factor: 9.461
Authors: Delphine Delample; Fabienne Durand; Arnold Severac; Monia Belghith; Emilie Mas; Francoise Michel; Jean-Paul Cristol; Maurice Hayot; Christian Prefaut Journal: Free Radic Res Date: 2008-09
Authors: M Muscaritoli; S D Anker; J Argilés; Z Aversa; J M Bauer; G Biolo; Y Boirie; I Bosaeus; T Cederholm; P Costelli; K C Fearon; A Laviano; M Maggio; F Rossi Fanelli; S M Schneider; A Schols; C C Sieber Journal: Clin Nutr Date: 2010-01-08 Impact factor: 7.324