OBJECTIVE: The aim of this study was to determine the implication of xanthine oxidase (XO) in the exercise-induced muscle oxidative stress and muscle dysfunction of these patients. METHODS: A randomized, crossover and double-blind study was conducted in nine severe COPD patients, who performed a localized quadriceps endurance test after oral treatment withallopurinol, a XO inhibitor or placebo. Redox status was studied in arterial and venous femoral blood before and after the endurance test. RESULTS: In placebo condition, muscle exercise resulted in a significant increase in AOPP and isoprostanes, with a significant increase in the venoarterial difference (v-a) in isoprostanes after exercise as compared with before (p<0.05). In contrast, allopurinol treatment prevented the elevation in AOPP levels and v-a isoprostanes after exercise. However, no significant improvement in quadriceps muscle endurance was observed, but allopurinol treatment seemed to preserve muscle strength properties. CONCLUSION: This study demonstrates that XO is implicated in the exercise-induced muscle oxidative stress of COPD patients. Allopurinol administration seemed to improve only some muscle properties. Therefore other sources of muscle oxidative stress should be implicated in muscle dysfunction observed in these patients.
RCT Entities:
OBJECTIVE: The aim of this study was to determine the implication of xanthine oxidase (XO) in the exercise-induced muscle oxidative stress and muscle dysfunction of these patients. METHODS: A randomized, crossover and double-blind study was conducted in nine severe COPDpatients, who performed a localized quadriceps endurance test after oral treatment with allopurinol, a XO inhibitor or placebo. Redox status was studied in arterial and venous femoral blood before and after the endurance test. RESULTS: In placebo condition, muscle exercise resulted in a significant increase in AOPP and isoprostanes, with a significant increase in the venoarterial difference (v-a) in isoprostanes after exercise as compared with before (p<0.05). In contrast, allopurinol treatment prevented the elevation in AOPP levels and v-a isoprostanes after exercise. However, no significant improvement in quadriceps muscle endurance was observed, but allopurinol treatment seemed to preserve muscle strength properties. CONCLUSION: This study demonstrates that XO is implicated in the exercise-induced muscle oxidative stress of COPDpatients. Allopurinol administration seemed to improve only some muscle properties. Therefore other sources of muscle oxidative stress should be implicated in muscle dysfunction observed in these patients.
Authors: Michael J Ryan; Janna R Jackson; Yanlei Hao; Stephen S Leonard; Stephen E Alway Journal: Free Radic Biol Med Date: 2011-04-07 Impact factor: 7.376
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Authors: Kada Klouche; Laurent Amigues; Marion Morena; Vincent Brunot; Anne Marie Dupuy; Audrey Jaussent; Marie Christine Picot; Noémie Besnard; Delphine Daubin; Jean Paul Cristol Journal: BMC Nephrol Date: 2017-12-22 Impact factor: 2.388
Authors: Thomas J Hureau; Joshua C Weavil; Simranjit K Sidhu; Taylor S Thurston; Van R Reese; Jia Zhao; Ashley D Nelson; Nathaniel M Birgenheier; Russell S Richardson; Markus Amann Journal: J Appl Physiol (1985) Date: 2020-11-05