| Literature DB >> 3081801 |
H Mori, S Sugie, N Yoshimi, J Kitamura, M Niwa, T Hamasaki, K Kawai.
Abstract
The genotoxicity and mutagenicity of 11 fungal metabolites structurally related to sterigmatocystin were examined in the hepatocyte primary culture/DNA-repair test and the Salmonella microsome assay. 10 out of the mycotoxins, i.e. dihydrosterigmatocystin, 5-methoxysterigmatocystin, 5-methoxydihydrosterigmatocystin, 5,6-dimethoxysterigmatocystin, 5,6-dimethoxydihydrosterigmatocystin, sterigmatin, O-methylsterigmatocystin and O-acetylsterigmatocystin showed a positive response for DNA repair, suggesting their carcinogenic potency. 5-Methoxysterigmatocystin, 5,6-dimethoxysterigmatocystin demethylsterigmatocystin and O-acetylsterigmatocystin were mutagenic in TA100 of the bacterial mutagenicity assay with liver S9.Entities:
Mesh：
Substances：
Year: 1986 PMID： 3081801 DOI： 10.1016/0165-7992(86)90039-4
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433