Literature DB >> 3267459

Genotoxicity in the hepatocyte/DNA repair test and toxicity to liver mitochondria of 1-hydroxyanthraquinone and several dihydroxyanthraquinones.

K Kawai1, H Mori, S Sugie, N Yoshimi, T Inoue, T Nakamaru, Y Nozawa, T Matsushima.   

Abstract

1-Hydroxyanthraquinone and dihydroxyanthraquinones (alizarin, quinizarin, anthrarufin and chrysazin) were examined for genotoxicity in the hepatocyte/DNA repair test and for effects on oxidative phosphorylation in isolated rat liver mitochondria. Of the anthraquinone compounds tested, 1-hydroxyanthraquinone and 1,8-dihydroxyanthraquinone (chrysazin) induced DNA repair synthesis in rat hepatocytes, indicating their genotoxic activity. Only 1,2-dihydroxyanthraquinone (alizarin) exerted an uncoupling and inhibitory effect on mitochondrial respiration. The possible relationships of the genotoxic potencies and the uncoupling activities of these anthraquinones to their chemical structures are discussed.

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Year:  1986        PMID： 3267459     DOI： 10.1007/bf00117848

Source DB:  PubMed          Journal:  Cell Biol Toxicol        ISSN： 0742-2091            Impact factor:   6.691


  35 in total

1.  Carcinogenicity of chrysazin in large intestine and liver of mice.

Authors:  H Mori; S Sugie; K Niwa; N Yoshimi; T Tanaka; I Hirono
Journal:  Jpn J Cancer Res       Date:  1986-09

2.  Inhibition of mitochondrial respiration by uncouplers of oxidative phosphorylation. II. The site of inhibition of succinate oxidation by the uncouplers.

Authors:  D F Wilson; R Merz
Journal:  Arch Biochem Biophys       Date:  1969-01       Impact factor: 4.013

3.  Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures.

Authors:  G M Williams
Journal:  Cancer Res       Date:  1977-06       Impact factor: 12.701

4.  NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.

Authors:  N R Bachur; S L Gordon; M V Gee; H Kon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

5.  Averufin, an anthraquinone mycotoxin possessing a potent uncoupling effect on mitochondrial respiration.

Authors:  K Kawai; Y Nozawa; Y Maebayashi; M Yamazaki; T Hamasaki
Journal:  Appl Environ Microbiol       Date:  1984-03       Impact factor: 4.792

6.  Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes.

Authors:  H Mori; K Kawai; F Ohbayashi; T Kuniyasu; M Yamazaki; T Hamasaki; G M Williams
Journal:  Cancer Res       Date:  1984-07       Impact factor: 12.701

7.  Genotoxicity of fungal metabolites related to aflatoxin B1 biosynthesis.

Authors:  H Mori; J Kitamura; S Sugie; K Kawai; T Hamasaki
Journal:  Mutat Res       Date:  1985-07       Impact factor: 2.433

8.  Inhibition of mitochondrial respiration by flavoskyrin, a toxic metabolite of Penicillium islandicum Sopp.

Authors:  K Kawai; Y Nozawa; H Mori; Y Ogihara
Journal:  Toxicol Lett       Date:  1986-02       Impact factor: 4.372

9.  Chronic toxicity and hepatocarcinogenicity of (+) rugulosin, an anthraquinoid mycotoxin from penicillium species: preliminary surveys in mice.

Authors:  Y Ueno; N Sato; T Ito; I Ueno; M Enomoto; H Tsunoda
Journal:  J Toxicol Sci       Date:  1980-11       Impact factor: 2.196

10.  Induction of intestinal tumours in rats by chrysazin.

Authors:  H Mori; S Sugie; K Niwa; M Takahashi; K Kawai
Journal:  Br J Cancer       Date:  1985-11       Impact factor: 7.640
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  3 in total

1.  Does senna extract promote growth of aberrant crypt foci and malignant tumors in rat colon?

Authors:  N Mascolo; E Mereto; F Borrelli; P Orsi; D Sini; A A Izzo; B Massa; M Boggio; F Capasso
Journal:  Dig Dis Sci       Date:  1999-11       Impact factor: 3.199

Review 2.  Marine Anthraquinones: Pharmacological and Toxicological Issues.

Authors:  Giulia Greco; Eleonora Turrini; Elena Catanzaro; Carmela Fimognari
Journal:  Mar Drugs       Date:  2021-05-13       Impact factor: 5.118

3.  Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase.

Authors:  Atsushi Furuta; Masayoshi Tsubuki; Miduki Endoh; Tatsuki Miyamoto; Junichi Tanaka; Kazi Abdus Salam; Nobuyoshi Akimitsu; Hidenori Tani; Atsuya Yamashita; Kohji Moriishi; Masamichi Nakakoshi; Yuji Sekiguchi; Satoshi Tsuneda; Naohiro Noda
Journal:  Int J Mol Sci       Date:  2015-08-07       Impact factor: 5.923
  3 in total

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