Literature DB >> 30792027

Trefoil Factor Family: Unresolved Questions and Clinical Perspectives.

Nayara Braga Emidio1, Werner Hoffmann2, Stuart M Brierley3, Markus Muttenthaler4.   

Abstract

The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  cell migration; gastrointestinal wound healing; lectin; mucins; mucosal protection; mucositis

Mesh：

Substances：

Year:  2019        PMID： 30792027      PMCID： PMC6557713          DOI： 10.1016/j.tibs.2019.01.004

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  15 in total

1.  CXCR4 and CXCR7 Mediate TFF3-Induced Cell Migration Independently From the ERK1/2 Signaling Pathway.

Authors:  Julia Dieckow; Wolfgang Brandt; Kirsten Hattermann; Stefan Schob; Ute Schulze; Rolf Mentlein; Philipp Ackermann; Saadettin Sel; Friedrich P Paulsen
Journal:  Invest Ophthalmol Vis Sci       Date:  2016-01-01       Impact factor: 4.799

Review 2.  Trefoil factor family-interacting proteins.

Authors:  W R Otto; L Thim
Journal:  Cell Mol Life Sci       Date:  2005-12       Impact factor: 9.261

3.  Human trefoil factor 2 is a lectin that binds α-GlcNAc-capped mucin glycans with antibiotic activity against Helicobacter pylori.

Authors:  Franz-Georg Hanisch; David Bonar; Nils Schloerer; Horst Schroten
Journal:  J Biol Chem       Date:  2014-08-14       Impact factor: 5.157

4.  Phase 1b, multicenter, single blinded, placebo-controlled, sequential dose escalation study to assess the safety and tolerability of topically applied AG013 in subjects with locally advanced head and neck cancer receiving induction chemotherapy.

Authors:  Sewanti Atul Limaye; Robert I Haddad; Fiona Cilli; Stephen T Sonis; A Dimitrios Colevas; Michael T Brennan; Kenneth S Hu; Barbara A Murphy
Journal:  Cancer       Date:  2013-09-24       Impact factor: 6.860

5.  Human intestinal TFF3 forms disulfide-linked heteromers with the mucus-associated FCGBP protein and is released by hydrogen sulfide.

Authors:  Timo K Albert; Werner Laubinger; Stefan Müller; Franz-Georg Hanisch; Thomas Kalinski; Frank Meyer; Werner Hoffmann
Journal:  J Proteome Res       Date:  2010-06-04       Impact factor: 4.466

6.  Phase II, randomized, double-blind, placebo-controlled study of recombinant human intestinal trefoil factor oral spray for prevention of oral mucositis in patients with colorectal cancer who are receiving fluorouracil-based chemotherapy.

Authors:  Douglas E Peterson; Nicholas P Barker; Lilia I Akhmadullina; Irina Rodionova; Nailya Z Sherman; Irina S Davidenko; Galina N Rakovskaya; Eugeny A Gotovkin; Sergey A Shinkarev; Mikhail V Kopp; Eugeny P Kulikov; Vladimir M Moiseyenko; Joseph M Gertner; Igor Firsov; Tamara Tuleneva; Alexander Yarosh; Chee-Wai Woon
Journal:  J Clin Oncol       Date:  2009-07-27       Impact factor: 44.544

7.  Helicobacter pylori lipopolysaccharide interacts with TFF1 in a pH-dependent manner.

Authors:  Emer P Reeves; Tehmeena Ali; Paul Leonard; Stephen Hearty; Richard O'Kennedy; Felicity E B May; Bruce R Westley; Christine Josenhans; Melanie Rust; Sebastian Suerbaum; Angeline Smith; Brendan Drumm; Marguerite Clyne
Journal:  Gastroenterology       Date:  2008-09-03       Impact factor: 22.682

8.  Trefoil factor 3 (TFF3) from human breast milk activates PAR-2 receptors, of the intestinal epithelial cells HT-29, regulating cytokines and defensins.

Authors:  G J Barrera; G Sanchez Tortolero
Journal:  Bratisl Lek Listy       Date:  2016       Impact factor: 1.278

9.  Commercial Porcine Gastric Mucin Preparations, also Used as Artificial Saliva, are a Rich Source for the Lectin TFF2: In Vitro Binding Studies.

Authors:  René Stürmer; Sönke Harder; Hartmut Schlüter; Werner Hoffmann
Journal:  Chembiochem       Date:  2018-11-27       Impact factor: 3.164

10.  A variant form of the human deleted in malignant brain tumor 1 (DMBT1) gene shows increased expression in inflammatory bowel diseases and interacts with dimeric trefoil factor 3 (TFF3).

Authors:  Jens Madsen; Grith Lykke Sorensen; Ole Nielsen; Ida Tornøe; Lars Thim; Claus Fenger; Jan Mollenhauer; Uffe Holmskov
Journal:  PLoS One       Date:  2013-05-15       Impact factor: 3.240
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  28 in total

Review 1.  Structure, Function, and Therapeutic Potential of the Trefoil Factor Family in the Gastrointestinal Tract.

Authors:  Nayara Braga Emidio; Stuart M Brierley; Christina I Schroeder; Markus Muttenthaler
Journal:  ACS Pharmacol Transl Sci       Date:  2020-06-09

2.  Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action.

Authors:  Nayara Braga Emidio; Hayeon Baik; David Lee; René Stürmer; Jörn Heuer; Alysha G Elliott; Mark A T Blaskovich; Katharina Haupenthal; Nicole Tegtmeyer; Werner Hoffmann; Christina I Schroeder; Markus Muttenthaler
Journal:  Chem Commun (Camb)       Date:  2020-05-11       Impact factor: 6.222

3.  29th Annual GP2A Medicinal Chemistry Conference.

Authors:  Jean-Jacques Helesbeux; Laura Carro; Florence O McCarthy; Vânia M Moreira; Francesca Giuntini; Niamh O'Boyle; Susan E Matthews; Gülşah Bayraktar; Samuel Bertrand; Christophe Rochais; Pascal Marchand
Journal:  Pharmaceuticals (Basel)       Date:  2021-12-07

4.  On the Utility of Chemical Strategies to Improve Peptide Gut Stability.

Authors:  Thomas Kremsmayr; Aws Aljnabi; Juan B Blanco-Canosa; Hue N T Tran; Nayara Braga Emidio; Markus Muttenthaler
Journal:  J Med Chem       Date:  2022-04-14       Impact factor: 8.039

Review 5.  Trefoil Factor Family (TFF) Peptides and Their Diverse Molecular Functions in Mucus Barrier Protection and More: Changing the Paradigm.

Authors:  Werner Hoffmann
Journal:  Int J Mol Sci       Date:  2020-06-25       Impact factor: 5.923

6.  Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair.

Authors:  Katharina Krüger; Sebastian Schmid; Friedrich Paulsen; Anita Ignatius; Patricia Klinger; Thilo Hotfiel; Bernd Swoboda; Kolja Gelse
Journal:  Int J Mol Sci       Date:  2019-09-01       Impact factor: 5.923

7.  Probiotics Upregulate Trefoil Factors and Downregulate Pepsinogen in the Mouse Stomach.

Authors:  Ghalia Khoder; Farah Al-Yassir; Asma Al Menhali; Prashanth Saseedharan; Subi Sugathan; Catherine Tomasetto; Sherif M Karam
Journal:  Int J Mol Sci       Date:  2019-08-10       Impact factor: 5.923

Review 8.  Trefoil Factor Family (TFF) Peptides and Their Links to Inflammation: A Re-evaluation and New Medical Perspectives.

Authors:  Werner Hoffmann
Journal:  Int J Mol Sci       Date:  2021-05-06       Impact factor: 5.923

9.  CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression.

Authors:  Hong-Yong Cui; Shi-Jie Wang; Fei Song; Xu Cheng; Gang Nan; Yu Zhao; Mei-Rui Qian; Xi Chen; Jia-Yue Li; Fen-Ling Liu; Yu-Meng Zhu; Ruo-Fei Tian; Bin Wang; Bin Wu; Yang Zhang; Xiu-Xuan Sun; Ting Guo; Xiang-Min Yang; Hai Zhang; Ling Li; Jing Xu; Hui-Jie Bian; Jian-Li Jiang; Zhi-Nan Chen
Journal:  Signal Transduct Target Ther       Date:  2021-07-14

10.  Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite.

Authors:  Nayara Braga Emidio; Rajeshwari Meli; Hue N T Tran; Hayeon Baik; Séverine Morisset-Lopez; Alysha G Elliott; Mark A T Blaskovich; Sabrina Spiller; Annette G Beck-Sickinger; Christina I Schroeder; Markus Muttenthaler
Journal:  J Med Chem       Date:  2021-06-18       Impact factor: 7.446
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