Literature DB >> 32391824

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action.

Nayara Braga Emidio1, Hayeon Baik, David Lee, René Stürmer, Jörn Heuer, Alysha G Elliott, Mark A T Blaskovich, Katharina Haupenthal, Nicole Tegtmeyer, Werner Hoffmann, Christina I Schroeder, Markus Muttenthaler.   

Abstract

TFF1 is a key peptide for gastrointestinal protection and repair. Its molecular mechanism of action remains poorly understood with synthetic intractability a recognised bottleneck. Here we describe the synthesis of TFF1 and its homodimer and their interactions with mucins and Helicobacter pylori. Synthetic access to TFF1 is an important milestone for probe and therapeutic development.

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Year:  2020        PMID： 32391824      PMCID： PMC7116170          DOI： 10.1039/d0cc02321c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  38 in total

1.  The solution structure of the disulphide-linked homodimer of the human trefoil protein TFF1.

Authors:  M A Williams; B R Westley; F E May; J Feeney
Journal:  FEBS Lett       Date:  2001-03-30       Impact factor: 4.124

2.  Interaction of trefoil family factors with mucins: clues to their mechanism of action?

Authors:  N A Wright
Journal:  Gut       Date:  2001-03       Impact factor: 23.059

3.  1H NMR-based determination of the secondary structure of porcine pancreatic spasmolytic polypeptide: one of a new family of "trefoil" motif containing cell growth factors.

Authors:  M D Carr
Journal:  Biochemistry       Date:  1992-02-25       Impact factor: 3.162

4.  Double-peak elution profile of a monoclonal antibody in cation exchange chromatography is caused by histidine-protonation-based charge variants.

Authors:  Haibin Luo; Mingyan Cao; Kelcy Newell; Christopher Afdahl; Jihong Wang; William K Wang; Yuling Li
Journal:  J Chromatogr A       Date:  2015-11-05       Impact factor: 4.759

5.  Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.

Authors:  Fernanda C Cardoso; Zoltan Dekan; Jennifer J Smith; Jennifer R Deuis; Irina Vetter; Volker Herzig; Paul F Alewood; Glenn F King; Richard J Lewis
Journal:  Br J Pharmacol       Date:  2017-06-27       Impact factor: 8.739

6.  Homodimerization and hetero-oligomerization of the single-domain trefoil protein pNR-2/pS2 through cysteine 58.

Authors:  M P Chadwick; B R Westley; F E May
Journal:  Biochem J       Date:  1997-10-01       Impact factor: 3.857

7.  Insights into the mechanism and catalysis of the native chemical ligation reaction.

Authors:  Erik C B Johnson; Stephen B H Kent
Journal:  J Am Chem Soc       Date:  2006-05-24       Impact factor: 15.419

8.  cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis.

Authors:  H Itoh; M Tomita; H Uchino; T Kobayashi; H Kataoka; R Sekiya; Y Nawa
Journal:  Biochem J       Date:  1996-09-15       Impact factor: 3.857

9.  1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects.

Authors:  D S Wishart; C G Bigam; A Holm; R S Hodges; B D Sykes
Journal:  J Biomol NMR       Date:  1995-01       Impact factor: 2.835

10.  The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis.

Authors:  Carine Bossenmeyer-Pourié; Rama Kannan; Stéphane Ribieras; Corinne Wendling; Isabelle Stoll; Lars Thim; Catherine Tomasetto; Marie-Christine Rio
Journal:  J Cell Biol       Date:  2002-05-28       Impact factor: 10.539
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  6 in total

Review 1.  Structure, Function, and Therapeutic Potential of the Trefoil Factor Family in the Gastrointestinal Tract.

Authors:  Nayara Braga Emidio; Stuart M Brierley; Christina I Schroeder; Markus Muttenthaler
Journal:  ACS Pharmacol Transl Sci       Date:  2020-06-09

Review 2.  Self-Renewal and Cancers of the Gastric Epithelium: An Update and the Role of the Lectin TFF1 as an Antral Tumor Suppressor.

Authors:  Werner Hoffmann
Journal:  Int J Mol Sci       Date:  2022-05-11       Impact factor: 6.208

3.  Improving the Gastrointestinal Stability of Linaclotide.

Authors:  Nayara Braga Emidio; Hue N T Tran; Asa Andersson; Philip E Dawson; Fernando Albericio; Irina Vetter; Markus Muttenthaler
Journal:  J Med Chem       Date:  2021-05-12       Impact factor: 7.446

Review 4.  Trefoil Factor Family (TFF) Peptides and Their Diverse Molecular Functions in Mucus Barrier Protection and More: Changing the Paradigm.

Authors:  Werner Hoffmann
Journal:  Int J Mol Sci       Date:  2020-06-25       Impact factor: 5.923

Review 5.  Trefoil Factor Family (TFF) Peptides and Their Links to Inflammation: A Re-evaluation and New Medical Perspectives.

Authors:  Werner Hoffmann
Journal:  Int J Mol Sci       Date:  2021-05-06       Impact factor: 5.923

6.  Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite.

Authors:  Nayara Braga Emidio; Rajeshwari Meli; Hue N T Tran; Hayeon Baik; Séverine Morisset-Lopez; Alysha G Elliott; Mark A T Blaskovich; Sabrina Spiller; Annette G Beck-Sickinger; Christina I Schroeder; Markus Muttenthaler
Journal:  J Med Chem       Date:  2021-06-18       Impact factor: 7.446
  6 in total

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