Literature DB >> 30790268

Response to antiseizure medications in neonates with acute symptomatic seizures.

Hannah C Glass1,2, Janet S Soul3, Catherine J Chu4, Shavonne L Massey5, Courtney J Wusthoff6, Taeun Chang7, Maria Roberta Cilio1, Sonia L Bonifacio8, Nicholas S Abend5,9, Cameron Thomas10, Monica Lemmon11, Charles E McCulloch2, Renée A Shellhaas12.   

Abstract

In a prospective cohort of 534 neonates with acute symptomatic seizures, 66% had incomplete response to the initial loading dose of antiseizure medication (ASM). Treatment response did not differ by gestational age, sex, medication, or dose. The risk of incomplete response was highest for seizures due to intracranial hemorrhage and lowest for hypoxic-ischemic encephalopathy, although the difference was not significant after adjusting for high seizure burden and therapeutic hypothermia treatment. Future trial design may test ASMs in neonates with all acute symptomatic seizure etiologies and could target neonates with seizures refractory to an initial ASM. Wiley Periodicals, Inc.
© 2019 International League Against Epilepsy.

Entities:  

Keywords:  zzm321990AEDzzm321990; antiepileptic drug; electroencephalogram; epilepsy; hypoxic-ischemic encephalopathy; neonatal encephalopathy; neonatal seizures; neurocritical care; seizure

Mesh：

Substances：

Year:  2019        PMID： 30790268      PMCID： PMC6443409          DOI： 10.1111/epi.14671

Source DB:  PubMed          Journal:  Epilepsia        ISSN： 0013-9580            Impact factor:   5.864


  11 in total

1.  The American Clinical Neurophysiology Society's Guideline on Continuous Electroencephalography Monitoring in Neonates.

Authors:  Renée A Shellhaas; Taeun Chang; Tammy Tsuchida; Mark S Scher; James J Riviello; Nicholas S Abend; Sylvie Nguyen; Courtney J Wusthoff; Robert R Clancy
Journal:  J Clin Neurophysiol       Date:  2011-12       Impact factor: 2.177

2.  Contemporary Profile of Seizures in Neonates: A Prospective Cohort Study.

Authors:  Hannah C Glass; Renée A Shellhaas; Courtney J Wusthoff; Taeun Chang; Nicholas S Abend; Catherine J Chu; M Roberta Cilio; David V Glidden; Sonia L Bonifacio; Shavonne Massey; Tammy N Tsuchida; Faye S Silverstein; Janet S Soul
Journal:  J Pediatr       Date:  2016-04-19       Impact factor: 4.406

Review 3.  American clinical neurophysiology society standardized EEG terminology and categorization for the description of continuous EEG monitoring in neonates: report of the American Clinical Neurophysiology Society critical care monitoring committee.

Authors:  Tammy N Tsuchida; Courtney J Wusthoff; Renée A Shellhaas; Nicholas S Abend; Cecil D Hahn; Joseph E Sullivan; Sylvie Nguyen; Steven Weinstein; Mark S Scher; James J Riviello; Robert R Clancy
Journal:  J Clin Neurophysiol       Date:  2013-04       Impact factor: 2.177

4.  Treatment Duration After Acute Symptomatic Seizures in Neonates: A Multicenter Cohort Study.

Authors:  Renée A Shellhaas; Taeun Chang; Courtney J Wusthoff; Janet S Soul; Shavonne L Massey; Catherine J Chu; M Roberta Cilio; Sonia L Bonifacio; Nicholas S Abend; Tammy N Tsuchida; Hannah C Glass
Journal:  J Pediatr       Date:  2016-11-07       Impact factor: 4.406

5.  Levetiracetam for treatment of neonatal seizures.

Authors:  Nicholas S Abend; Ana M Gutierrez-Colina; Heather M Monk; Dennis J Dlugos; Robert R Clancy
Journal:  J Child Neurol       Date:  2011-01-13       Impact factor: 1.987

6.  Phenobarbital compared with phenytoin for the treatment of neonatal seizures.

Authors:  M J Painter; M S Scher; A D Stein; S Armatti; Z Wang; J C Gardiner; N Paneth; B Minnigh; J Alvin
Journal:  N Engl J Med       Date:  1999-08-12       Impact factor: 91.245

7.  Pharmacokinetics of levetiracetam in neonates with seizures.

Authors:  Stephanie L Merhar; Kurt R Schibler; Catherine M Sherwin; Jareen Meinzen-Derr; Jing Shi; Tonya Balmakund; Alexander A Vinks
Journal:  J Pediatr       Date:  2011-05-18       Impact factor: 4.406

8.  A seven-day study of the pharmacokinetics of intravenous levetiracetam in neonates: marked changes in pharmacokinetics occur during the first week of life.

Authors:  Cynthia M Sharpe; Edmund V Capparelli; Andrew Mower; Michael J Farrell; Steven J Soldin; Richard H Haas
Journal:  Pediatr Res       Date:  2012-04-11       Impact factor: 3.756

9.  Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial.

Authors:  Ronit M Pressler; Geraldine B Boylan; Neil Marlow; Mats Blennow; Catherine Chiron; J Helen Cross; Linda S de Vries; Boubou Hallberg; Lena Hellström-Westas; Vincent Jullien; Vicki Livingstone; Barry Mangum; Brendan Murphy; Deirdre Murray; Gerard Pons; Janet Rennie; Renate Swarte; Mona C Toet; Sampsa Vanhatalo; Sarah Zohar
Journal:  Lancet Neurol       Date:  2015-03-10       Impact factor: 44.182

10.  Intravenous levetiracetam for treatment of neonatal seizures.

Authors:  Abhijeet Rakshasbhuvankar; Shripada Rao; Rolland Kohan; Karen Simmer; Lakshmi Nagarajan
Journal:  J Clin Neurosci       Date:  2013-05-07       Impact factor: 1.961
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  9 in total

1.  Targeting ischemia-induced KCC2 hypofunction rescues refractory neonatal seizures and mitigates epileptogenesis in a mouse model.

Authors:  Brennan J Sullivan; Pavel A Kipnis; Brandon M Carter; Li-Rong Shao; Shilpa D Kadam
Journal:  Sci Signal       Date:  2021-11-09       Impact factor: 8.192

2.  Rescue of PB-resistant neonatal seizures with single-dose of small-molecule TrkB antagonist show long-term benefits.

Authors:  S K Kang; S Ammanuel; D A Adler; S D Kadam
Journal:  Epilepsy Res       Date:  2019-12-09       Impact factor: 3.045

3.  Characteristics of Neonates with Cardiopulmonary Disease Who Experience Seizures: A Multicenter Study.

Authors:  Shavonne L Massey; Hannah C Glass; Renée A Shellhaas; Sonia Bonifacio; Taeun Chang; Catherine Chu; Maria Roberta Cilio; Monica E Lemmon; Charles E McCulloch; Janet S Soul; Cameron Thomas; Courtney J Wusthoff; Rui Xiao; Nicholas S Abend
Journal:  J Pediatr       Date:  2021-10-30       Impact factor: 4.406

4.  Family-Centered Care for Children and Families Impacted by Neonatal Seizures: Advice From Parents.

Authors:  Monica E Lemmon; Hannah C Glass; Renée A Shellhaas; Mary Carol Barks; Simran Bansal; Dana Annis; Jennifer L Guerriero; Betsy Pilon; Courtney J Wusthoff; Taeun Chang; Janet S Soul; Catherine J Chu; Cameron Thomas; Shavonne L Massey; Nicholas S Abend; Stephanie Rau; Elizabeth E Rogers; Linda S Franck
Journal:  Pediatr Neurol       Date:  2021-07-30       Impact factor: 3.372

Review 5.  Novel Therapeutics for Neonatal Seizures.

Authors:  Julie M Ziobro; Krista Eschbach; Renée A Shellhaas
Journal:  Neurotherapeutics       Date:  2021-08-12       Impact factor: 6.088

6.  Sex specific correlation between GABAergic disruption in the dorsal hippocampus and flurothyl seizure susceptibility after neonatal hypoxic-ischemic brain injury.

Authors:  Charles R Lechner; Melanie A McNally; Mark St Pierre; Ryan J Felling; Frances J Northington; Carl E Stafstrom; Raul Chavez-Valdez
Journal:  Neurobiol Dis       Date:  2020-12-09       Impact factor: 5.996

Review 7.  Treating the symptom or treating the disease in neonatal seizures: a systematic review of the literature.

Authors:  Raffaele Falsaperla; Bruna Scalia; Andrea Giugno; Piero Pavone; Milena Motta; Martina Caccamo; Martino Ruggieri
Journal:  Ital J Pediatr       Date:  2021-04-07       Impact factor: 2.638

8.  Population Pharmacokinetics of Phenobarbital in Neonates and Infants on Extracorporeal Membrane Oxygenation and the Influence of Concomitant Renal Replacement Therapy.

Authors:  Céline Thibault; Shavonne L Massey; Nicholas S Abend; Maryam Y Naim; Alexandra Zoraian; Athena F Zuppa
Journal:  J Clin Pharmacol       Date:  2020-09-22       Impact factor: 3.126

9.  Seizure Control in Neonates Undergoing Screening vs Confirmatory EEG Monitoring.

Authors:  Courtney J Wusthoff; Vandana Sundaram; Nicholas S Abend; Shavonne L Massey; Monica E Lemmon; Cameron Thomas; Charles E McCulloch; Taeun Chang; Janet S Soul; Catherine J Chu; Elizabeth E Rogers; Sonia Lomeli Bonifacio; Maria Roberta Cilio; Hannah C Glass; Renée A Shellhaas
Journal:  Neurology       Date:  2021-06-02       Impact factor: 9.910
  9 in total

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