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Literature DB >> 21592494

Pharmacokinetics of levetiracetam in neonates with seizures.

Stephanie L Merhar¹, Kurt R Schibler, Catherine M Sherwin, Jareen Meinzen-Derr, Jing Shi, Tonya Balmakund, Alexander A Vinks.

Abstract

The pharmacokinetics of levetiracetam were determined prospectively in 18 neonates with seizures. Neonates were found to have lower clearance, higher volume of distribution, and a longer half-life as compared with older children and adults. Mild somnolence was the only adverse effect.

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Year: 2011 PMID： 21592494 PMCID： PMC3789844 DOI： 10.1016/j.jpeds.2011.03.057

Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406

16 in total

1. Levetiracetam: safety and efficacy in neonatal seizures.

Authors: Georgia Ramantani; Chrysanthy Ikonomidou; Beate Walter; Dietz Rating; Juergen Dinger
Journal: Eur J Paediatr Neurol Date: 2010-11-19 Impact factor: 3.140

2. Antiepileptic drugs and apoptotic neurodegeneration in the developing brain.

Authors: Petra Bittigau; Marco Sifringer; Kerstin Genz; Ellen Reith; Dana Pospischil; Suresh Govindarajalu; Mark Dzietko; Stefanie Pesditschek; Ingrid Mai; Krikor Dikranian; John W Olney; Chrysanthy Ikonomidou
Journal: Proc Natl Acad Sci U S A Date: 2002-11-04 Impact factor: 11.205

3. Determination of levetiracetam in human plasma/serum/saliva by liquid chromatography-electrospray tandem mass spectrometry.

Authors: Tiedong Guo; Lisa M Oswald; Damodara Rao Mendu; Steven J Soldin
Journal: Clin Chim Acta Date: 2006-06-27 Impact factor: 3.786

4. Phenobarbital for febrile seizures--effects on intelligence and on seizure recurrence.

Authors: J R Farwell; Y J Lee; D G Hirtz; S I Sulzbacher; J H Ellenberg; K B Nelson
Journal: N Engl J Med Date: 1990-02-08 Impact factor: 91.245

5. Efficacy and safety of levetiracetam: an add-on trial in children with refractory epilepsy.

Authors: S Grosso; E Franzoni; G Coppola; P Iannetti; A Verrotti; D M Cordelli; V Marchiani; A Pascotto; A Spalice; B Acampora; G Morgese; P Balestri
Journal: Seizure Date: 2005-06 Impact factor: 3.184

6. Pharmacokinetic study of levetiracetam in children.

Authors: J M Pellock; T A Glauser; E M Bebin; N B Fountain; F J Ritter; R M Coupez; W D Shields
Journal: Epilepsia Date: 2001-12 Impact factor: 5.864

7. Efficacy and safety of levetiracetam in infants and young children with refractory epilepsy.

Authors: S Grosso; D M Cordelli; E Franzoni; G Coppola; G Capovilla; N Zamponi; A Verrotti; G Morgese; P Balestri
Journal: Seizure Date: 2007-03-26 Impact factor: 3.184

Review 8. Clinical pharmacokinetics of levetiracetam.

Authors: Philip N Patsalos
Journal: Clin Pharmacokinet Date: 2004 Impact factor: 6.447

9. Pharmacokinetics of levetiracetam in infants and young children with epilepsy.

Authors: Tracy A Glauser; Wendy G Mitchell; Arie Weinstock; Martina Bebin; Dion Chen; Rene Coupez; Armel Stockis; Zhihong Sarah Lu
Journal: Epilepsia Date: 2007-04-18 Impact factor: 5.864

10. Levetiracetam for the treatment of neonatal seizures.

Authors: Michael T Shoemaker; Joshua S Rotenberg
Journal: J Child Neurol Date: 2007-01 Impact factor: 1.987

25 in total

Review 1. Pharmacotherapy for Seizures in Neonates with Hypoxic Ischemic Encephalopathy.

Authors: Elissa Yozawitz; Arthur Stacey; Ronit M Pressler
Journal: Paediatr Drugs Date: 2017-12 Impact factor: 3.022

2. Population pharmacokinetics modeling of levetiracetam in Chinese children with epilepsy.

Authors: Ying-hui Wang; Li Wang; Wei Lu; De-wei Shang; Min-ji Wei; Ye Wu
Journal: Acta Pharmacol Sin Date: 2012-06 Impact factor: 6.150

Review 3. Treating disorders of the neonatal central nervous system: pharmacokinetic and pharmacodynamic considerations with a focus on antiepileptics.

Authors: Maria D Donovan; Geraldine B Boylan; Deirdre M Murray; John F Cryan; Brendan T Griffin
Journal: Br J Clin Pharmacol Date: 2015-11-04 Impact factor: 4.335

4. Response of levetiracetam in neonatal seizures.

Authors: Maggie Lo-Yee Yau; Eva Lai-Wah Fung; Pak Cheung Ng
Journal: World J Clin Pediatr Date: 2015-08-08

5. Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial.

Authors: Cynthia Sharpe; Gail E Reiner; Suzanne L Davis; Mark Nespeca; Jeffrey J Gold; Maynard Rasmussen; Rachel Kuperman; Mary Jo Harbert; David Michelson; Priscilla Joe; Sonya Wang; Neggy Rismanchi; Ngoc Minh Le; Andrew Mower; Jae Kim; Malcolm R Battin; Brian Lane; Jose Honold; Ellen Knodel; Kathy Arnell; Renee Bridge; Lilly Lee; Karin Ernstrom; Rema Raman; Richard H Haas
Journal: Pediatrics Date: 2020-05-08 Impact factor: 7.124

Review 6. Levetiracetam in neonatal seizures: a review.

Authors: Allison L Mruk; Karen L Garlitz; Noelle R Leung
Journal: J Pediatr Pharmacol Ther Date: 2015 Mar-Apr

7. Response to antiseizure medications in neonates with acute symptomatic seizures.

Authors: Hannah C Glass; Janet S Soul; Catherine J Chu; Shavonne L Massey; Courtney J Wusthoff; Taeun Chang; Maria Roberta Cilio; Sonia L Bonifacio; Nicholas S Abend; Cameron Thomas; Monica Lemmon; Charles E McCulloch; Renée A Shellhaas
Journal: Epilepsia Date: 2019-02-20 Impact factor: 5.864