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Literature DB >> 34386906

Novel Therapeutics for Neonatal Seizures.

Julie M Ziobro¹, Krista Eschbach², Renée A Shellhaas³.

Abstract

Neonatal seizures are a common neurologic emergency for which therapies have not significantly changed in decades. Improvements in diagnosis and pathophysiologic understanding of the distinct features of acute symptomatic seizures and neonatal-onset epilepsies present exceptional opportunities for development of precision therapies with potential to improve outcomes. Herein, we discuss the pathophysiology of neonatal seizures and review the evidence for currently available treatment. We present emerging therapies in clinical and preclinical development for the treatment of acute symptomatic neonatal seizures. Lastly, we discuss the role of precision therapies for genetic neonatal-onset epilepsies and address barriers and goals for developing new therapies for clinical care.

Entities: Chemical

Keywords: Antiseizure medication; Bumetanide; Hypoxic-ischemic encephalopathy; KCNQ2; Levetiracetam; Phenobarbital

Mesh：

Substances：

Year: 2021 PMID： 34386906 PMCID： PMC8608938 DOI： 10.1007/s13311-021-01085-8

Source DB: PubMed Journal: Neurotherapeutics ISSN： 1878-7479 Impact factor: 6.088

172 in total

1. The temporal evolution of electrographic seizure burden in neonatal hypoxic ischemic encephalopathy.

Authors: Niamh E Lynch; Nathan J Stevenson; Vicki Livingstone; Brendan P Murphy; Janet M Rennie; Geraldine B Boylan
Journal: Epilepsia Date: 2012-02-06 Impact factor: 5.864

2. Design and implementation of electronic health record common data elements for pediatric epilepsy: Foundations for a learning health care system.

Authors: Zachary M Grinspan; Anup D Patel; Renée A Shellhaas; Anne T Berg; Erika T Axeen; Jeffrey Bolton; David F Clarke; Jason Coryell; William D Gaillard; Howard P Goodkin; Sookyong Koh; Alison Kukla; Juma S Mbwana; Lindsey A Morgan; Nilika S Singhal; Margaret M Storey; Elissa G Yozawitz; Nicholas S Abend; Mark P Fitzgerald; Sara E Fridinger; Ingo Helbig; Shavonne L Massey; Marisa S Prelack; Jeffrey Buchhalter
Journal: Epilepsia Date: 2020-12-24 Impact factor: 5.864

3. Treatment with brivaracetam in children - The experience of a pediatric epilepsy center.

Authors: Andreea Nissenkorn; Michal Tzadok; Omer Bar-Yosef; Bruria Ben-Zeev
Journal: Epilepsy Behav Date: 2019-11-04 Impact factor: 2.937

4. High seizure load during sensitive periods of development leads to broad shifts in ultrasonic vocalization behavior in neonatal male and female C57BL/6J mice.

Authors: Suzanne O Nolan; Samantha L Hodges; Siena M Condon; Ilyasah D A Muhammed; Lindsay A Tomac; Matthew S Binder; Conner D Reynolds; Joaquin N Lugo
Journal: Epilepsy Behav Date: 2019-04-22 Impact factor: 2.937

Novel Therapeutics for Neonatal Seizures.

1. The temporal evolution of electrographic seizure burden in neonatal hypoxic ischemic encephalopathy.

2. Design and implementation of electronic health record common data elements for pediatric epilepsy: Foundations for a learning health care system.

3. Treatment with brivaracetam in children - The experience of a pediatric epilepsy center.

4. High seizure load during sensitive periods of development leads to broad shifts in ultrasonic vocalization behavior in neonatal male and female C57BL/6J mice.

5. Levetiracetam for treatment of neonatal seizures.

6. Current knowledge for pyridoxine-dependent epilepsy: a 2016 update.

7. Lacosamide improves outcome in a murine model of traumatic brain injury.

Review 8. Potassium channel genes and benign familial neonatal epilepsy.

9. Dose-dependent effects of levetiracetam after hypoxia and hypothermia in the neonatal mouse brain.

10. Dose-dependent reversal of KCC2 hypofunction and phenobarbital-resistant neonatal seizures by ANA12.

1. Precision Treatments in Epilepsy.