Priyatansh Gurha1. 1. Center for Cardiovascular Genetics, Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Texas, USA.
Abstract
PURPOSE OF REVIEW: Human genome is pervasively transcribed, producing coding and noncoding RNAs. Recent studies have revealed the roles of a class of noncoding RNAs, the long noncoding RNAs (lncRNAs), in heart failure and other cardiovascular diseases. This review provides a brief summary of recent findings on lncRNA function. RECENT FINDINGS: Recent studies have documented the roles of lncRNAs in cardiac regeneration, conduction, hypertrophy/dysfunction, and endothelial function. LncRNAs perform these functions through acting as competing RNA (by binding and sequestering MicroRNAs) or acting as guides to protein targeting. A few lncRNAs also encode small peptides (e.g., Dwarf Open Reading Frame RNA) and in the context of heart regulate cardiac calcium homeostasis. SUMMARY: Noncoding RNA provides a versatile mechanism of gene regulation and thereby present as novel targets for intervention in various cardiovascular disease. Future studies aimed at defining the context-dependent lncRNA mechanisms will be required to advance our understanding and relish the goal of RNA therapeutics.
PURPOSE OF REVIEW: Human genome is pervasively transcribed, producing coding and noncoding RNAs. Recent studies have revealed the roles of a class of noncoding RNAs, the long noncoding RNAs (lncRNAs), in heart failure and other cardiovascular diseases. This review provides a brief summary of recent findings on lncRNA function. RECENT FINDINGS: Recent studies have documented the roles of lncRNAs in cardiac regeneration, conduction, hypertrophy/dysfunction, and endothelial function. LncRNAs perform these functions through acting as competing RNA (by binding and sequestering MicroRNAs) or acting as guides to protein targeting. A few lncRNAs also encode small peptides (e.g., Dwarf Open Reading Frame RNA) and in the context of heart regulate cardiac calcium homeostasis. SUMMARY: Noncoding RNA provides a versatile mechanism of gene regulation and thereby present as novel targets for intervention in various cardiovascular disease. Future studies aimed at defining the context-dependent lncRNA mechanisms will be required to advance our understanding and relish the goal of RNA therapeutics.
Authors: Mohammed Rabiul Hosen; Giuseppe Militello; Tyler Weirick; Yuliya Ponomareva; Sujith Dassanayaka; Joseph B Moore; Claudia Döring; Marcin Wysoczynski; Steven P Jones; Stefanie Dimmeler; Shizuka Uchida Journal: Circ Res Date: 2018-02-26 Impact factor: 17.367
Authors: Catherine A Makarewich; Amir Z Munir; Gabriele G Schiattarella; Svetlana Bezprozvannaya; Olga N Raguimova; Ellen E Cho; Alexander H Vidal; Seth L Robia; Rhonda Bassel-Duby; Eric N Olson Journal: Elife Date: 2018-10-09 Impact factor: 8.140