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Literature DB >> 30740315

From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein.

Felicia L Lenzo^1,2, William G Cance^2,3,4,5.

Abstract

Entities: CellLine Chemical Disease Gene Mutation Species

Year: 2017 PMID： 30740315 PMCID： PMC6366834 DOI： 10.21037/tcr.2017.06.05

Source DB: PubMed Journal: Transl Cancer Res ISSN： 2218-676X Impact factor: 1.241

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25 in total

1. Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation status.

Authors: Michael S Gordon; Daniela Matei; Carol Aghajanian; Ursula A Matulonis; Molly Brewer; Gini F Fleming; John D Hainsworth; Agustin A Garcia; Mark D Pegram; Russell J Schilder; David E Cohn; Lynda Roman; Mika K Derynck; Kimmie Ng; Benjamin Lyons; David E Allison; David A Eberhard; Thinh Q Pham; Randall C Dere; Beth Y Karlan
Journal: J Clin Oncol Date: 2006-08-08 Impact factor: 44.544

Review 2. Focal adhesion kinase: in command and control of cell motility.

Authors: Satyajit K Mitra; Daniel A Hanson; David D Schlaepfer
Journal: Nat Rev Mol Cell Biol Date: 2005-01 Impact factor: 94.444

3. Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

Authors: Gordon W McLean; Noboru H Komiyama; Bryan Serrels; Hidefumi Asano; Louise Reynolds; Francesco Conti; Kairbaan Hodivala-Dilke; Daniel Metzger; Pierre Chambon; Seth G N Grant; Margaret C Frame
Journal: Genes Dev Date: 2004-12-15 Impact factor: 11.361

4. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.

Authors: Vita M Golubovskaya; Richard Finch; William G Cance
Journal: J Biol Chem Date: 2005-04-25 Impact factor: 5.157

Review 5. The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.

Authors: Gordon W McLean; Neil O Carragher; Egle Avizienyte; Jeff Evans; Valerie G Brunton; Margaret C Frame
Journal: Nat Rev Cancer Date: 2005-07 Impact factor: 60.716

6. Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses.

Authors: Amy L Lark; Chad A Livasy; Benjamin Calvo; Laura Caskey; Dominic T Moore; XiHui Yang; William G Cance
Journal: Clin Cancer Res Date: 2003-01 Impact factor: 12.531

Review 7. Src and focal adhesion kinase as therapeutic targets in cancer.

Authors: Valerie G Brunton; Margaret C Frame
Journal: Curr Opin Pharmacol Date: 2008-07-22 Impact factor: 5.547

Review 8. Role of the tumor microenvironment in mediating de novo resistance to drugs and physiological mediators of cell death.

Authors: Lori A Hazlehurst; Terry H Landowski; William S Dalton
Journal: Oncogene Date: 2003-10-20 Impact factor: 9.867