| Literature DB >> 16069815 |
Gordon W McLean1, Neil O Carragher, Egle Avizienyte, Jeff Evans, Valerie G Brunton, Margaret C Frame.
Abstract
Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell proliferation, cell survival and cell migration. Given that the development of malignancy is often associated with perturbations in these processes, it is not surprising that FAK activity is altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target.Entities:
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Year: 2005 PMID： 16069815 DOI： 10.1038/nrc1647
Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716