Literature DB >> 18625340

Src and focal adhesion kinase as therapeutic targets in cancer.

Valerie G Brunton1, Margaret C Frame.   

Abstract

Over the past few years small molecule inhibitors of both Src family kinases and focal adhesion kinase (FAK) have entered clinical studies for the treatment of solid tumours. These adhesion-linked kinases are involved in a number of pathways that have impact on the behaviour of tumour cells and the challenge is now, how to take these forward in the clinical setting.

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Year:  2008        PMID: 18625340     DOI: 10.1016/j.coph.2008.06.012

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN: 1471-4892            Impact factor:   5.547


  87 in total

Review 1.  Narrative review: the systemic capillary leak syndrome.

Authors:  Kirk M Druey; Philip R Greipp
Journal:  Ann Intern Med       Date:  2010-07-20       Impact factor: 25.391

2.  Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation.

Authors:  Laura C Kelley; Amanda Gatesman Ammer; Karen E Hayes; Karen H Martin; Kazuya Machida; Lin Jia; Bruce J Mayer; Scott A Weed
Journal:  J Cell Sci       Date:  2010-10-27       Impact factor: 5.285

Review 3.  Integrin α3β1 as a breast cancer target.

Authors:  Sita Subbaram; C Michael Dipersio
Journal:  Expert Opin Ther Targets       Date:  2011-08-13       Impact factor: 6.902

4.  Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics.

Authors:  Marta Canel; Alan Serrels; Derek Miller; Paul Timpson; Bryan Serrels; Margaret C Frame; Valerie G Brunton
Journal:  Cancer Res       Date:  2010-11-02       Impact factor: 12.701

5.  A novel 2-aminobenzimidazole-based compound Jzu 17 exhibits anti-angiogenesis effects by targeting VEGFR-2 signalling.

Authors:  Jin-Cherng Lien; Chi-Li Chung; Tur-Fu Huang; Tsung-Chia Chang; Kuan-Chung Chen; Ging-Yan Gao; Ming-Jen Hsu; Shiu-Wen Huang
Journal:  Br J Pharmacol       Date:  2019-09-15       Impact factor: 8.739

6.  Targeting the C-terminal focal adhesion kinase scaffold in pancreatic cancer.

Authors:  Priyanka N Gogate; Elena V Kurenova; Manivannan Ethirajan; Jianqun Liao; Michael Yemma; Arindam Sen; Ravindra K Pandey; William G Cance
Journal:  Cancer Lett       Date:  2014-07-24       Impact factor: 8.679

Review 7.  Function and regulation of the Arp2/3 complex during cell migration in diverse environments.

Authors:  Kristen F Swaney; Rong Li
Journal:  Curr Opin Cell Biol       Date:  2016-05-08       Impact factor: 8.382

8.  Microfabricated Systems and Assays for Studying the Cytoskeletal Organization, Micromechanics, and Motility Patterns of Cancerous Cells.

Authors:  Sabil Huda; Didzis Pilans; Monika Makurath; Thomas Hermans; Kristiana Kandere-Grzybowska; Bartosz A Grzybowski
Journal:  Adv Mater Interfaces       Date:  2014-08-28       Impact factor: 6.147

9.  The effects of cell compressibility, motility and contact inhibition on the growth of tumor cell clusters using the Cellular Potts Model.

Authors:  Jonathan F Li; John Lowengrub
Journal:  J Theor Biol       Date:  2013-11-06       Impact factor: 2.691

10.  PPemd26, an anthraquinone derivative, suppresses angiogenesis via inhibiting VEGFR2 signalling.

Authors:  S W Huang; J C Lien; S C Kuo; T F Huang
Journal:  Br J Pharmacol       Date:  2014-12       Impact factor: 8.739

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