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Literature DB >> 30733305

Biomarkers of Exposure among U.S. Adult Cigar Smokers: Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014).

Cindy M Chang¹, Brian L Rostron², Joanne T Chang², Catherine G Corey², Heather L Kimmel³, Connie S Sosnoff⁴, Maciej L Goniewicz⁵, Kathryn C Edwards⁶, Dorothy K Hatsukami⁷, Yuesong Wang⁴, Arseima Y Del Valle-Pinero², Maocheng Yang², Mark J Travers⁵, Stephen Arnstein⁴, Kristie Taylor⁶, Kevin Conway³, Bridget K Ambrose², Nicolette Borek², Andrew Hyland⁵, Lanqing Wang⁴, Benjamin C Blount⁴, Dana M van Bemmel².

Abstract

BACKGROUND: Given the diverse cigar market and limited data on biomarker patterns by cigar type, we compared biomarkers of nicotine and tobacco toxicants among cigar smokers and other groups.
METHODS: Using Wave 1 urinary biomarker data from 5,604 adults in the Population Assessment of Tobacco and Health (PATH) Study, we compared geometric mean concentrations among cigar-only smokers (all cigars and separately for traditional, cigarillo, and filtered cigars), cigarette-only smokers, dual cigar/cigarette smokers, and never users of tobacco. We calculated geometric mean ratios comparing groups with never users adjusting for sex, age, race/ethnicity, education and creatinine.
RESULTS: Some day cigar-only smokers had lower biomarker concentrations than every day cigar-only smokers, but higher than never users. Every day cigar-only smokers (n = 61) had lower TNE-2 (cotinine+trans-3'-hydroxycotinine) compared to every day cigarette-only (n = 2217; P < 0.0001) and dual cigar/cigarette smokers (n = 601; P < 0.0001). Several biomarkers, including NNAL (NNK metabolite) and CYMA (metabolite of acrylonitrile), were comparable in these groups. In exploratory analyses, every day filtered cigar-only (n = 7) smokers had higher biomarker concentrations compared with every day traditional cigar-only smokers (n = 12) and cigarillo-only smokers (n = 24). Every day smokers of each cigar type were similar to exclusive cigarette smokers. For some biomarkers, particularly for every day filtered cigar-only smokers, concentrations were higher.
CONCLUSIONS: For some biomarkers, every day cigar-only smokers were comparable with every day cigarette-only smokers. Exploratory analyses suggest that biomarkers vary by cigar type with every day filtered cigar-only smokers having the highest concentrations. IMPACT: High exposure to harmful constituents among cigar smokers is a continuing health issue. ©2019 American Association for Cancer Research.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2019 PMID： 30733305 PMCID： PMC6500461 DOI： 10.1158/1055-9965.EPI-18-0539

Source DB: PubMed Journal: Cancer Epidemiol Biomarkers Prev ISSN： 1055-9965 Impact factor: 4.254

33 in total

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2. Acute Effects of "Hyping" a Black&Mild Cigarillo.

Authors: Melissa D Blank; Caroline O Cobb; Thomas Eissenberg; Aashir Nasim
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3. Ethnic differences in N-glucuronidation of nicotine and cotinine.

Authors: N L Benowitz; E J Perez-Stable; I Fong; G Modin; B Herrera; P Jacob
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4. Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention.

Authors: Stephen S Hecht; Jian-Min Yuan; Dorothy Hatsukami
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5. Acute effects of cigarillo smoking.

Authors: Melissa D Blank; Aashir Nasim; Alton Hart; Thomas Eissenberg
Journal: Nicotine Tob Res Date: 2011-04-18 Impact factor: 4.244

6. Effects of smoking and inhalation of carbon monoxide on systolic time intervals and blood pressure. Differences between two types of cigarettes and a cigar.

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Journal: Chest Date: 1979-02 Impact factor: 9.410

7. Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: impact of CYP2A6 genetic variation and enzymatic activity.

Authors: Neal L Benowitz; Gideon St Helen; Delia A Dempsey; Peyton Jacob; Rachel F Tyndale
Journal: Pharmacogenet Genomics Date: 2016-07 Impact factor: 2.089

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Journal: Occup Environ Med Date: 1998-12 Impact factor: 4.402

9. US Adult Cigar Smoking Patterns, Purchasing Behaviors, and Reasons for Use According to Cigar Type: Findings From the Population Assessment of Tobacco and Health (PATH) Study, 2013-2014.

Authors: Catherine G Corey; Enver Holder-Hayes; Anh B Nguyen; Cristine D Delnevo; Brian L Rostron; Maansi Bansal-Travers; Heather L Kimmel; Amber Koblitz; Elizabeth Lambert; Jennifer L Pearson; Eva Sharma; Cindy Tworek; Andrew J Hyland; Kevin P Conway; Bridget K Ambrose; Nicolette Borek
Journal: Nicotine Tob Res Date: 2018-11-15 Impact factor: 4.244

10. Close, but no cigar: certain cigars are pseudo-cigarettes designed to evade regulation.

Authors: Cristine D Delnevo; Mary Hrywna; Daniel P Giovenco; Erin J Miller Lo; Richard J O'Connor
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15 in total

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Authors: Vernon E Walker; Dale M Walker; Burhan I Ghanayem; George R Douglas
Journal: Chem Res Toxicol Date: 2020-06-28 Impact factor: 3.739

2. Tobacco-Specific Nitrosamines (NNAL, NNN, NAT, and NAB) Exposures in the US Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014).

Authors: Baoyun Xia; Benjamin C Blount; Tonya Guillot; Christina Brosius; Yao Li; Dana M Van Bemmel; Heather L Kimmel; Cindy M Chang; Nicolette Borek; Kathryn C Edwards; Charlie Lawrence; Andrew Hyland; Maciej L Goniewicz; Brittany N Pine; Yang Xia; John T Bernert; B Rey De Castro; John Lee; Justin L Brown; Stephen Arnstein; Diane Choi; Erin L Wade; Dorothy Hatsukami; Gladys Ervies; Angel Cobos; Keegan Nicodemus; Dana Freeman; Stephen S Hecht; Kevin Conway; Lanqing Wang
Journal: Nicotine Tob Res Date: 2021-02-16 Impact factor: 4.244

3. Internalizing problems are associated with initiation and past 30-Day use of flavored tobacco products.

Authors: Ollie Ganz; Amy M Cohn; Renee D Goodwin; Daniel P Giovenco; Olivia A Wackowski; Eugene M Talbot; Cristine D Delnevo
Journal: Addict Behav Date: 2021-10-26 Impact factor: 3.913

4. Hand Nicotine and Cotinine In Children Exposed to Cigars: A Pilot Study.

Authors: E Melinda Mahabee-Gittens; Georg E Matt; Roman J Jandarov; Ashley L Merianos
Journal: Tob Regul Sci Date: 2021-05

5. Public health impact of a US ban on menthol in cigarettes and cigars: a simulation study.

Authors: David T Levy; Rafael Meza; Zhe Yuan; Yameng Li; Christopher Cadham; Luz Maria Sanchez-Romero; Nargiz Travis; Marie Knoll; Alex C Liber; Ritesh Mistry; Jana L Hirschtick; Nancy L Fleischer; Sarah Skolnick; Andrew F Brouwer; Cliff Douglas; Jihyoun Jeon; Steven Cook; Kenneth E Warner
Journal: Tob Control Date: 2021-09-02 Impact factor: 6.953

6. Cluster analysis of urinary tobacco biomarkers among U.S. adults: Population Assessment of Tobacco and Health (PATH) biomarker study (2013-2014).

Authors: Ban Majeed; Daniel Linder; Thomas Eissenberg; Yelena Tarasenko; Danielle Smith; David Ashley
Journal: Prev Med Date: 2020-07-18 Impact factor: 4.018