Literature DB >> 20408564

Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention.

Stephen S Hecht1, Jian-Min Yuan, Dorothy Hatsukami.   

Abstract

Tobacco carcinogen and toxicant biomarkers are metabolites or protein or DNA adducts of specific compounds in tobacco products. Highly reliable analytical methods, based mainly on mass spectrometry, have been developed and applied in large studies of many of these biomarkers. A panel of tobacco carcinogen and toxicant biomarkers is suggested here, and typical values for smokers and nonsmokers are summarized. This panel of biomarkers has potential applications in the new and challenging area of tobacco product regulation and in the development of rational approaches to cancer prevention by establishing carcinogen and toxicant uptake and excretion in people exposed to tobacco products.

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Year:  2010        PMID： 20408564      PMCID： PMC2891118          DOI： 10.1021/tx100056m

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN： 0893-228X            Impact factor:   3.739


  80 in total

1.  Levels of prostaglandin E metabolite, the major urinary metabolite of prostaglandin E2, are increased in smokers.

Authors:  Neil D Gross; Jay O Boyle; Jason D Morrow; Myles K Williams; Chaya S Moskowitz; Kotha Subbaramaiah; Andrew J Dannenberg; Anna J Duffield-Lillico
Journal:  Clin Cancer Res       Date:  2005-08-15       Impact factor: 12.531

Review 2.  Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans.

Authors:  Jason D Morrow
Journal:  Arterioscler Thromb Vasc Biol       Date:  2004-12-09       Impact factor: 8.311

Review 3.  Biomonitoring of inhaled complex mixtures--ambient air, diesel exhaust and cigarette smoke.

Authors:  Gerhard Scherer
Journal:  Exp Toxicol Pathol       Date:  2005-07

4.  Similar uptake of lung carcinogens by smokers of regular, light, and ultralight cigarettes.

Authors:  Stephen S Hecht; Sharon E Murphy; Steven G Carmella; Shelby Li; Joni Jensen; Chap Le; Anne M Joseph; Dorothy K Hatsukami
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2005-03       Impact factor: 4.254

Review 5.  Metabolism and disposition kinetics of nicotine.

Authors:  Janne Hukkanen; Peyton Jacob; Neal L Benowitz
Journal:  Pharmacol Rev       Date:  2005-03       Impact factor: 25.468

6.  Tobacco-specific nitrosamines and their pyridine-N-glucuronides in the urine of smokers and smokeless tobacco users.

Authors:  Irina Stepanov; Stephen S Hecht
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2005-04       Impact factor: 4.254

7.  Carcinogen exposure during short-term switching from regular to "light" cigarettes.

Authors:  Neal L Benowitz; Peyton Jacob; John T Bernert; Margaret Wilson; Langing Wang; Faith Allen; Delia Dempsey
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2005-06       Impact factor: 4.254

8.  A randomized, controlled exposure study in adult smokers of full flavor Marlboro cigarettes switching to Marlboro Lights or Marlboro Ultra Lights cigarettes.

Authors:  Paul Mendes; Sunil Kapur; Jingzhu Wang; Shixia Feng; Hans Roethig
Journal:  Regul Toxicol Pharmacol       Date:  2008-05-11       Impact factor: 3.271

Review 9.  Acrylamide carcinogenicity.

Authors:  James E Klaunig
Journal:  J Agric Food Chem       Date:  2008-07-15       Impact factor: 5.279

10.  Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide.

Authors: 
Journal:  IARC Monogr Eval Carcinog Risks Hum       Date:  1999
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  51 in total

1.  Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China.

Authors:  Thomas W Kensler; Derek Ng; Steven G Carmella; Menglan Chen; Lisa P Jacobson; Alvaro Muñoz; Patricia A Egner; Jian Guo Chen; Geng Sun Qian; Tao Yang Chen; Jed W Fahey; Paul Talalay; John D Groopman; Jian-Min Yuan; Stephen S Hecht
Journal:  Carcinogenesis       Date:  2011-11-01       Impact factor: 4.944

2.  Analysis of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human leukocyte DNA from smokers and nonsmokers.

Authors:  Siyi Zhang; Silvia Balbo; Mingyao Wang; Stephen S Hecht
Journal:  Chem Res Toxicol       Date:  2010-11-22       Impact factor: 3.739

3.  Analysis of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene in human urine: a biomarker for directly assessing carcinogenic polycyclic aromatic hydrocarbon exposure plus metabolic activation.

Authors:  Yan Zhong; Steven G Carmella; J Bradley Hochalter; Silvia Balbo; Stephen S Hecht
Journal:  Chem Res Toxicol       Date:  2010-11-04       Impact factor: 3.739

4.  Biomarkers of Tobacco Exposure: Summary of an FDA-Sponsored Public Workshop.

Authors:  Cindy M Chang; Selvin H Edwards; Aarthi Arab; Arseima Y Del Valle-Pinero; Ling Yang; Dorothy K Hatsukami
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2016-11-09       Impact factor: 4.254

5.  Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers.

Authors:  Stephen S Hecht; Steven G Carmella; Delshanee Kotandeniya; Makenzie E Pillsbury; Menglan Chen; Benjamin W S Ransom; Rachel Isaksson Vogel; Elizabeth Thompson; Sharon E Murphy; Dorothy K Hatsukami
Journal:  Nicotine Tob Res       Date:  2014-10-21       Impact factor: 4.244

6.  A Randomized Clinical Trial of Snus Examining the Effect of Complete Versus Partial Cigarette Substitution on Smoking-Related Behaviors, and Biomarkers of Exposure.

Authors:  Ellen Meier; Bruce R Lindgren; Amanda Anderson; Sarah A Reisinger; Kaila J Norton; Joni Jensen; Lori Strayer; Laura Dick; Mei-Kuen Tang; Menglan Chen; Steven G Carmella; Stephen S Hecht; Sharon E Murphy; Jing Yang; Irina Stepanov; Richard J O'Connor; Peter G Shields; Dorothy K Hatsukami
Journal:  Nicotine Tob Res       Date:  2020-04-17       Impact factor: 4.244

7.  Tobacco smoke biomarkers and cancer risk among male smokers in the Shanghai cohort study.

Authors:  Stephen S Hecht; Sharon E Murphy; Irina Stepanov; Heather H Nelson; Jian-Min Yuan
Journal:  Cancer Lett       Date:  2012-07-20       Impact factor: 8.679

8.  Elevated levels of 1-hydroxypyrene and N'-nitrosonornicotine in smokers with head and neck cancer: A matched control study.

Authors:  Samir S Khariwala; Steven G Carmella; Irina Stepanov; Patricia Fernandes; Amy Anne Lassig; Bevan Yueh; Dorothy Hatsukami; Stephen S Hecht
Journal:  Head Neck       Date:  2012-07-17       Impact factor: 3.147

9.  Analysis of the benzene oxide-DNA adduct 7-phenylguanine by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry-parallel reaction monitoring: application to DNA from exposed mice and humans.

Authors:  Adam T Zarth; Guang Cheng; Zhaobin Zhang; Mingyao Wang; Peter W Villalta; Silvia Balbo; Stephen S Hecht
Journal:  Chem Biol Interact       Date:  2014-03-13       Impact factor: 5.192

10.  Fifty years of tobacco carcinogenesis research: from mechanisms to early detection and prevention of lung cancer.

Authors:  Stephen S Hecht; Eva Szabo
Journal:  Cancer Prev Res (Phila)       Date:  2014-01
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