Ingrid de Chazeron1, Franck Durif2, Isabelle Chereau-Boudet3, Maria Livia Fantini2, Ana Marques2, Philippe Derost2, Berengere Debilly2, Georges Brousse3, Yves Boirie4, Pierre Michel Llorca3. 1. Service de Psychiatrie B, CHU Clermont-Ferrand, EA7280, Université Clermont Auvergne, Clermont-Ferrand, Rue Montalembert BP 69, 63003, Clermont-Ferrand, France. idechazeron@chu-clermontferrand.fr. 2. Service de neurologie A, CHU Clermont-Ferrand, EA7280, Université Clermont Auvergne, Clermont-Ferrand, France. 3. Service de Psychiatrie B, CHU Clermont-Ferrand, EA7280, Université Clermont Auvergne, Clermont-Ferrand, Rue Montalembert BP 69, 63003, Clermont-Ferrand, France. 4. Service de nutrition clinique, CHU Clermont-Ferrand, INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, France.
Abstract
PURPOSE: Eating disorders are common in Parkinson's disease (PD) patients and often class in Impulse control disorders, however, little is known about their phenomenology. Specific symptoms and comorbidities were described in a group of PD patients in this preliminary study. METHODS: Over a period of 6 months, 51 PD patients who experienced significant changes in eating habits following diagnosis of PD and were interviewed during regularly scheduled follow-up visits. We assessed each patient's height and weight, impulsivity, psychological distress, current eating disorder symptoms, food addiction, food habits and craving. RESULTS: Among the PD patients who experienced modified dietary habits following diagnosis, few exhibited binge eating disorders (BED) full criteria (3.9%). However, 21.6% of patients experienced episodes of out-of-control eating with a large quantity of food in short time and 39.2% satisfied food addiction (FA) criteria without binge eating disorder. Food cravings more than once a week were experienced in approximately half of the population including all FA patients. Regarding comorbidities, FA PD patients present impulsive features and anxiety. CONCLUSIONS: This study confirms the existence of FA profile in PD patients. Eating disorders even in PD are complex and have a cross-cutting criteria related to out-of-control eating, FA, and BED. The association of anxiety with PD-related food addiction, contrary to L-dopa equivalent daily dose mean score or the presence of dopamine agonists, underline the complex sustainability of the dopaminergic brainstem support. A study on their detailed prevalence in this population could be helpful to better understand unspecified feeding or eating disorder. CLINICAL TRIAL NUMBER: DR-2012-007. NAME OF THE REGISTRY: French Committee for the Protection of Persons (CPP) & French National Commission on Computing and Liberty (CNIL). LEVEL OF EVIDENCE: Level V, descriptive study.
PURPOSE: Eating disorders are common in Parkinson's disease (PD) patients and often class in Impulse control disorders, however, little is known about their phenomenology. Specific symptoms and comorbidities were described in a group of PD patients in this preliminary study. METHODS: Over a period of 6 months, 51 PD patients who experienced significant changes in eating habits following diagnosis of PD and were interviewed during regularly scheduled follow-up visits. We assessed each patient's height and weight, impulsivity, psychological distress, current eating disorder symptoms, food addiction, food habits and craving. RESULTS: Among the PD patients who experienced modified dietary habits following diagnosis, few exhibited binge eating disorders (BED) full criteria (3.9%). However, 21.6% of patients experienced episodes of out-of-control eating with a large quantity of food in short time and 39.2% satisfied food addiction (FA) criteria without binge eating disorder. Food cravings more than once a week were experienced in approximately half of the population including all FA patients. Regarding comorbidities, FA PD patients present impulsive features and anxiety. CONCLUSIONS: This study confirms the existence of FA profile in PD patients. Eating disorders even in PD are complex and have a cross-cutting criteria related to out-of-control eating, FA, and BED. The association of anxiety with PD-related food addiction, contrary to L-dopa equivalent daily dose mean score or the presence of dopamine agonists, underline the complex sustainability of the dopaminergic brainstem support. A study on their detailed prevalence in this population could be helpful to better understand unspecified feeding or eating disorder. CLINICAL TRIAL NUMBER: DR-2012-007. NAME OF THE REGISTRY: French Committee for the Protection of Persons (CPP) & French National Commission on Computing and Liberty (CNIL). LEVEL OF EVIDENCE: Level V, descriptive study.
Authors: Antonio Preti; Giovanni de Girolamo; Gemma Vilagut; Jordi Alonso; Ron de Graaf; Ronny Bruffaerts; Koen Demyttenaere; Alejandra Pinto-Meza; Josep Maria Haro; Piero Morosini Journal: J Psychiatr Res Date: 2009-05-08 Impact factor: 4.791